2015
DOI: 10.1186/s40348-015-0013-7
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Bronchopulmonary dysplasia - an overview about pathophysiologic concepts

Abstract: Neonatal chronic lung disease in the preterm infant, i.e. bronchopulmonary dysplasia (BPD) is characterized by impaired pulmonary development with its effects persisting into adulthood. Triggered in the immature lung by infectious complications, oxygen toxicity and the impact of mechanical ventilation, a sustained inflammatory response, extensive remodeling of the extracellular matrix, increased apoptosis as well as altered growth factor signaling characterize the disease. The current review focuses on selecte… Show more

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Cited by 53 publications
(64 citation statements)
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References 33 publications
(63 reference statements)
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“…Therefore, we suggest that ginger has antiinflammatory properties by decreasing neutrophil activation and migration into the lungs with evidence of reduced MPO activity in the lungs (9,11). Oxygen toxicity has a key role in the development of BPD (1)(2)(3)(4)(5)(6)(7). High concentrations of inspired oxygen can damage lung cells by the overproduction of cytotoxic reactive oxygen species (ROS) such as superoxide free radical, hydrogen peroxide, and hydroxyl free radical.…”
Section: Discussionmentioning
confidence: 99%
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“…Therefore, we suggest that ginger has antiinflammatory properties by decreasing neutrophil activation and migration into the lungs with evidence of reduced MPO activity in the lungs (9,11). Oxygen toxicity has a key role in the development of BPD (1)(2)(3)(4)(5)(6)(7). High concentrations of inspired oxygen can damage lung cells by the overproduction of cytotoxic reactive oxygen species (ROS) such as superoxide free radical, hydrogen peroxide, and hydroxyl free radical.…”
Section: Discussionmentioning
confidence: 99%
“…One of the most important risk factors in the development of BPD is believed to be preterm birth (1)(2)(3)(4)(5)(6). Once a premature baby is born, he or she does not have fully developed lungs to adapt to external life.…”
Section: Discussionmentioning
confidence: 99%
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“…Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease affecting preterm infants born in the late canalicular or early saccular stage of lung development caused, in part, by exposure to high concentration of oxygen (hyperoxia) that results in impaired alveolarization and compromised vasculogenesis [13]. Patients with BPD often have poor long-term outcomes with increased infections, interstitial fibrotic changes, small airway abnormalities, or emphysema that can persist into adulthood and all treatment options have failed to produce effective clinical outcomes [4, 5].…”
Section: Introductionmentioning
confidence: 99%