Ginger ( Zingiber officinale ) prevents severe damage to the lungs due to hyperoxia and  inflammation

doi:10.3906/sag-1803-223

Cited by 17 publications

(10 citation statements)

References 39 publications

(99 reference statements)

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“…Nonetheless, ginger has proven to relieve symptoms associated with COVID-19 infection such as chest pain. Ginger has proven to reduce chest pain and induce relaxation in airway smooth muscle, hindering airway resistance and inflammation as shown in Table 3 ( 166 ).…”

Section: Methodsmentioning

confidence: 99%

Prospective Medicinal Plants and Their Phytochemicals Shielding Autoimmune and Cancer Patients Against the SARS-CoV-2 Pandemic: A Special Focus on Matcha

et al. 2022

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BackgroundBeing “positive” has been one of the most frustrating words anyone could hear since the end of 2019. This word had been overused globally due to the high infectious nature of SARS-CoV-2. All citizens are at risk of being infected with SARS-CoV-2, but a red warning sign has been directed towards cancer and immune-compromised patients in particular. These groups of patients are not only more prone to catch the virus but also more predisposed to its deadly consequences, something that urged the research community to seek other effective and safe solutions that could be used as a protective measurement for cancer and autoimmune patients during the pandemic.AimThe authors aimed to turn the spotlight on specific herbal remedies that showed potential anticancer activity, immuno-modulatory roles, and promising anti-SARS-CoV-2 actions.MethodologyTo attain the purpose of the review, the research was conducted at the States National Library of Medicine (PubMed). To search databases, the descriptors used were as follows: “COVID-19”/”SARS-CoV-2”, “Herbal Drugs”, “Autoimmune diseases”, “Rheumatoid Arthritis”, “Asthma”, “Multiple Sclerosis”, “Systemic Lupus Erythematosus” “Nutraceuticals”, “Matcha”, “EGCG”, “Quercetin”, “Cancer”, and key molecular pathways.ResultsThis manuscript reviewed most of the herbal drugs that showed a triple action concerning anticancer, immunomodulation, and anti-SARS-CoV-2 activities. Special attention was directed towards “matcha” as a novel potential protective and therapeutic agent for cancer and immunocompromised patients during the SARS-CoV-2 pandemic.ConclusionThis review sheds light on the pivotal role of “matcha” as a tri-acting herbal tea having a potent antitumorigenic effect, immunomodulatory role, and proven anti-SARS-CoV-2 activity, thus providing a powerful shield for high-risk patients such as cancer and autoimmune patients during the pandemic.

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Section: Methodsmentioning

confidence: 99%

Prospective Medicinal Plants and Their Phytochemicals Shielding Autoimmune and Cancer Patients Against the SARS-CoV-2 Pandemic: A Special Focus on Matcha

et al. 2022

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“…The oily extract of the ginger rhizome was shown to reduce the LPS-induced IL-8 secretion suggesting that the ginger extract has anti-inflammatory effects on bronchial epithelial cells. 55 In another study on 36 newborn Wistar rats, ginger extract was shown to reduce the lung damage from severe damage due to hyperoxia and inflammation. 56 In the same study, it was seen that tissue TNF-α, IL-1β, and IL-6 concentrations were decreased in the animals treated with ginger in comparison to the placebo group.…”

Section: Ayurvedic Immunity-promoting Herbsmentioning

confidence: 98%

SARS-CoV (COVID-19) Pandemic—Detailed Insights into Diagnosis, Management, and Role of Indian Herbal Drugs

Kumar¹,

Singh²,

Thaman³

et al. 2020

AMEI's Current Trends in Diagnosis &Amp; Treatment

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Coronavirus-2019 (COVID-19) (SARS-CoV-2), a pandemic by World Health Organization on March 11, 2020, is caused by corona viruses which is highly contagious with enveloped positive-sense RNA particles with a size of 60-140 nm in diameter. The COVID-19 infection may be an asymptomatic, mild, moderate or severe illness with severe potentially lethal complications, such as severe pneumonia, respiratory failure, acute respiratory distress syndrome, sepsis, and septic shock due to induction of cytological storm. Diagnostic confirmation is by reverse transcription polymerase chain reaction. The treatment is mainly symptomatic with management of complications. Antiviral drugs like lopinavir administration have not been proven very useful and other drugs, such as Arbidol and favipiravir have some hope. Remdesivir, a drug approved by USFDA, has shown benefits in critical patients with COVID-19 infection. The mode of action of chloroquine and hydroxychloroquine is via immunomodulatory effects. Ministry of AYUSH has recommended intake of ayurvedic herbal drugs like curcumin, tulsi, cinnamon, black pepper, ashwagandha, shunthi (dry ginger), and regular yoga. Curcumin and garlic are important anticytokine agents and decrease various substances like interleukin (IL)-1β, IL-10, and IL-12 by macrophages with additional fibrinolytic and antiplatelet aggregatory actions. Amla is an immunity booster. Tulsi due to phytocompounds and apigenin might be useful in COVID-19 infection. Cinnamomum has eugenol with antiviral activity. Black pepper suppresses the nuclear factor kappa-B signaling pathway. Ginger (Zingiber officinale) decreases various proinflammatory chemokines IL-8 and regulated upon activation, normal T-cell expressed and secreted. Mulethi has saponins which inhibit in vitro several DNA-and RNA-viruses. Thus, Indian herbal system of Ayurveda is very useful in COVID-19 infection.

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“…Oleoresin, gingerol, shogaol, and zingerone from ginger increased the percentage of CD3+CD4+ thus improving cellular and humoral immune response in HIV patients ( Tejasari, 2007 ). Ginger also alleviated bronchopulmonary dysplasia and inflammation induced by hyperoxia and intrauterine LPS in a chorioamnionitis rat model ( Cifci et al., 2018 ).…”

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

Oladele¹,

Ajayi

Oyeleke³

et al. 2020

Heliyon

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Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2. Available clinical intervention for COVID-19 is only palliative and limited to support. Thus, there is an exigent need for effective and non-invasive treatment. This article evaluates the possible mechanism of actions of SARS-CoV-2 and present Nigeria based medicinal plants which have pharmacological and biological activities that can mitigate the hallmarks of the pathogenesis of COVID-19. SARS-CoV-2 mode of actions includes hyper-inflammation characterized by a severe and fatal hyper-cytokinaemia with multi-organ failure; immunosuppression; reduction of angiotensin-converting enzyme 2 (ACE2) to enhance pulmonary vascular permeability causing damage to the alveoli; and further activated by open reading frame (ORF)3a, ORF3b, and ORF7a via c-Jun N- terminal kinase (JNK) pathway which induces lung damage. These mechanisms of action of SARS-CoV-2 can be mitigated by a combination therapy of medicinal herbs based on their pharmacological activities. Since the clinical manifestations of COVID-19 are multifactorial with co-morbidities, we strongly recommend the use of combined therapy such that two or more herbs with specific therapeutic actions are administered to combat the mediators of the disease.

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Ginger ( Zingiber officinale ) prevents severe damage to the lungs due to hyperoxia and inflammation

Cited by 17 publications

References 39 publications

Prospective Medicinal Plants and Their Phytochemicals Shielding Autoimmune and Cancer Patients Against the SARS-CoV-2 Pandemic: A Special Focus on Matcha

Prospective Medicinal Plants and Their Phytochemicals Shielding Autoimmune and Cancer Patients Against the SARS-CoV-2 Pandemic: A Special Focus on Matcha

SARS-CoV (COVID-19) Pandemic—Detailed Insights into Diagnosis, Management, and Role of Indian Herbal Drugs

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

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