Abstract:Background: Both oral and intravenous inhibitors of cyclic nucleotide phosphodiesterase (PDE) 3 and PDE4 have been shown to have bronchodilator and/or pulmonary antiallergic effects but their adverse effects limit the clinical use. The purpose of the present study was to assess the bronchoprotective effect of intrabronchial administration of a selective PDE3 inhibitor, 6–[4–(1–cyclohexyl–1H–tetrazol–5–yl)butoxy]–3,4–dihydro–2(1H)–quinolinone (cilostazol), in dry power form which is proposed to be desirable rat… Show more
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