Bronchopleural fistula after pneumonectomy

Abstract

Hand suture closure of bronchial stump after pneumonectomy is a safe, reproducible and inexpensive technique, and a low incidence of BPF can be achieved.

Diabetes Mellitus and Risk of Bronchopleural Fistula After Pulmonary Resections: A Meta-Analysis

“…Then, 18 of them were considered for possible eligibility for quantitative synthesis [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Finally, a total of 15 studies met the eligibility criteria and were included in our meta-analysis [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. The other three studies were finally excluded because details of DM and BPF formation were incomplete [32][33][34].…”

“…The basic characteristics of the 15 studies are summarized in Table 1. All of them were retrospective observational studies [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. More than half of these studies (n ¼ 8) were conducted in Asian countries, including four in Japan [17,19,27,29], two in China [20,31], one in Korea [25], and one in Turkey [30].…”

“…However, only three studies published the adjusted results of multivariate analysis, including the OR with 95% CI in one study [28] and the b value with corresponding SE in two studies [17,20]. In this metaanalysis, the majority of the OR outcomes were extrapolated from the demographic data based on univariate analysis [19,[21][22][23][24][25][26][27][29][30][31]. Birdas and colleagues [18] did not report the clinical data but provided the OR with 95% CI from univariate analysis.…”

“…For further assessing the impact of DM on the risk of BPF, we classified all cases into several subgroups according to statistical analysis, diagnoses, operative modes, and the patients' origins. In the subgroups classified by statistical analysis, the summarized outcomes based on the data from both univariate analysis (OR ¼ 1.89; 95% CI ¼ 1.17 to 3.05; p ¼ 0.009) [18,19,[21][22][23][24][25][26][27][29][30][31] and multivariate analysis (OR ¼ 2.07; 95% CI ¼ 1.24 to 3.45; p ¼ 0.006) [17,20,28] indicated that DM was significantly associated with an increased risk of postoperative BPF, with low heterogeneity (Table 3 and Fig 3A).…”

“…In the subgroups classified by diagnoses, we quantitatively pooled the data of 5,260 lung cancer cases from 12 studies [17,[19][20][21][22][23][24][25][26][27][28][29] but gave up further assessment of benign diseases because the other three studies [18,30,31] enrolled both malignant and benign diseases but analyzed them together. The pooled OR was 1.95 (95% CI ¼ 1.35 to 2.84; p < 0.001), indicating that DM could predispose to BPF formation in patients undergoing lung cancer operations (Table 3 and Fig 3B) without any heterogeneity (I 2 ¼ 0.0%, p ¼ 0.69).…”