Diabetes Mellitus and Risk of Bronchopleural Fistula After Pulmonary Resections: A Meta-Analysis

Li, Shuangjiang; Fan, Jin‐Hu; Zhou, Jian; Ren, Yaoyao; Shen, Cheng; Che, Guowei

doi:10.1016/j.athoracsur.2016.01.013

Cited by 50 publications

(36 citation statements)

References 49 publications

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“…This relationship of diabetes mellitus and worse outcomes after pulmonary resection has been previously described. Diabetes mellitus is a presumed independent risk factor for bronchopleural fistula after pulmonary resections, with an odds ratio (OR) of 2 (37).…”

Section: Discussionmentioning

confidence: 99%

Effect of gender on perioperative outcomes after robotic-assisted pulmonary lobectomy

et al. 2016

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Background: Female gender has been associated with worse outcomes after cardiovascular surgery and critical illness. We investigated the effect of gender on perioperative outcomes following robotic-assisted pulmonary lobectomy. 44.5%; P=0.004), the most common of which, in both women and men, were prolonged air leak for ≥7 days (13.0% vs. 22.7%, P=0.03), atrial fibrillation (7.1% vs. 14.8%, P=0.04), and pneumonia (7.8% vs. 10.2%, P=0.49). Hospital length of stay (LOS) (4±0.3 vs. 5±0.5 days) was also shorter for women (P=0.02). Despite the higher postoperative complication rate in men, in-hospital mortality did not differ between genders (P=0.23). Multivariable analyses did not identify female gender as an independent predictor of post-operative complications. Conclusions: Female gender was associated with rates of intraoperative complications and of conversion to open lobectomy as low as those for men, but with better perioperative outcomes, lower risk of intraoperative bleeding, and fewer postoperative complications. Thus, robotic-assisted pulmonary lobectomy is feasible and safe for women.

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Section: Discussionmentioning

confidence: 99%

Effect of gender on perioperative outcomes after robotic-assisted pulmonary lobectomy

et al. 2016

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“…It is generally proposed that multivariate analysis using Cox proportional hazards model or logistic regression is usually adopted to eliminate the potential bias risks from other confounding factors in observational studies [25–27, 29]. In this meta-analysis, no multivariate OR statistic was reported to assess the relationship between mTOR/p-mTOR expression and clinicopathological features of ESCC.…”

Section: Discussionmentioning

confidence: 99%

“…Fourth, it has been generally recognized that studies reporting beneficial intervention effects or a larger effect size are more likely to be published, while an equal amount of data towards the other directions may remain unpublished [29]. This phenomenon suggests that we cannot avoid the potential publication bias between studies included into a meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

“…This phenomenon suggests that we cannot avoid the potential publication bias between studies included into a meta-analysis. However, less than 10 included studies can lead to a large decline on the efficacy of publication bias tests, resulting in the potentially misleading evidence for publication bias [25–29]. As for our meta-analysis, no more than 10 studies were included into each analysis for either clinicopathological characteristics or prognosis of ESCC.…”

Section: Discussionmentioning

confidence: 99%

“…Meta-analysis is generally regarded as a well-established method synthesizing the appropriate evidence from homogeneous studies to draw global conclusions [25–29]. Therefore, we carried out the current systematic review with meta-analysis to evaluate the prognostic and clinicopathological significance of mTOR/p-mTOR expression in patients with ESCC.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and prognostic significance of mTOR and phosphorylated mTOR expression in patients with esophageal squamous cell carcinoma: a systematic review and meta-analysis

Wang

Huang

et al. 2016

BMC Cancer

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BackgroundMammalian target of rapamycin (mTOR) is a serine/threonine protein kinase responsible for regulating ribosomal biogenesis and protein synthesis. Dysregulation of mTOR contributes to tumorigenesis, angiogenesis, cellular growth and metastasis but its roles in esophageal squamous cell carcinoma (ESCC) are controversial. Therefore, the objective of this study is to evaluate the prognostic and clinicopathological significance of mTOR/p-mTOR expression in ESCC.MethodsLiterature retrieval was conducted by searching PubMed, EMBASE and the Web of Science for full-text papers that met our eligibility criteria. Odds ratio (OR) and hazard ratio (HR) with 95 % confidence interval (CI) served as the appropriate summarized statistics for assessments of clinicopathological and prognostic significance, respectively. Cochrane Q-test and I2-statistic were adopted to estimate the heterogeneity level between studies. Potential publication bias was detected by Begg’s test and Egger’s test.ResultsA total of 915 ESCC patients from nine original articles were included into this meta-analysis. The pooled analyses suggested that mTOR/p-mTOR expression was significantly correlated with the unfavorable outcomes of differentiation degree (OR: 2.63; 95 % CI: 1.71–4.05; P = 0.001), tumor invasion (OR: 1.48; 95 % CI: 1.02–2.13; P = 0.037), TNM stage (OR: 2.25; 95 % CI: 1.05–4.82; P = 0.037) and lymph node metastasis (OR: 1.82; 95 % CI: 1.06–3.11; P = 0.029), but had no significant relationship to the genders (OR: 0.81; 95 % CI: 0.50–1.32; P = 0.396). Moreover, mTOR/p-mTOR expression could independently predict the worse overall survival (HR: 2.04; 95 % CI: 1.58–2.62; P < 0.001), disease-free survival (HR: 2.39; 95 % CI: 1.64–3.49; P < 0.001) and cancer-specific survival (HR: 1.62; 95 % CI: 1.18–2.23; P = 0.003) of patients with ESCC. Such prognostic value of mTOR was not substantially altered by further subgroup analyses.ConclusionsPositive expression of mTOR and p-mTOR was significantly associated with the unfavorable conditions on the depth of tumor invasion, TNM stage, differentiation degree and lymph node metastasis. mTOR and p-mTOR could serve as a valuable predictor for the poor prognosis of ESCC. More high-quality worldwide studies performing a multivariate analysis based on larger sample size are urgently required for further verifying and modifying our findings in the future.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-016-2940-7) contains supplementary material, which is available to authorized users.

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Bronchopleural Fistulae

Levin¹

2019

Principles and Practice of Anesthesia for Thoracic Surgery

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Diabetes Mellitus and Risk of Bronchopleural Fistula After Pulmonary Resections: A Meta-Analysis

Cited by 50 publications

References 49 publications

Effect of gender on perioperative outcomes after robotic-assisted pulmonary lobectomy

Effect of gender on perioperative outcomes after robotic-assisted pulmonary lobectomy

Clinicopathological and prognostic significance of mTOR and phosphorylated mTOR expression in patients with esophageal squamous cell carcinoma: a systematic review and meta-analysis

Bronchopleural Fistulae

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