Bronchogenic Carcinoma with Inappropriate Antidiuretic Activity in Plasma and Tumor

Bower, B.; Mason, Donald M.; Forsham, Peter H.; HALE, JEAN H.

doi:10.1056/nejm196410292711804

Cited by 70 publications

(12 citation statements)

References 22 publications

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“…In 1964 Bower, Mason, and Forsham (11) demonstrated antidiuretic activity in plasma as well as lung tumor and metastases from such a patient, again using the rat bioassay. They also performed bioassays in rats with stereotactically placed hypothalamic lesions and permanent diabetes insipidus and proved that the active principle of the tumor was not acting in the assay animal by stimulating the hypothalamus or posterior pituitary gland to release vasopressin.…”

Section: Discussionmentioning

confidence: 97%

Biosynthesis of Vasopressin In Vitro and Ultrastructure of a Bronchogenic Carcinoma

George¹,

Capen²,

Phillips³

1972

J. Clin. Invest.

119

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A B S T R A C T Tumors from patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) have been found to contain large amounts of the antidiuretic hormone vasopressin. A lung tumor from a patient with hyponatremia most likely due to SIADH was removed at surgery and found to contain 23.5 mU vasopressin/g wet weight by radioimmunoassay Slices of this tumor were incubated with phenylalanine-3H. Arginine vasopressin-H was purified from the incubate by Sephadex G-25 column chromatography in two different systems, performic acid oxidation, and gradient elution column chromatography with diethylaminoethyl Sephadex. As oxidation of vasopressin results in drastic conformational change with breaking of the ring of the cyclic polypeptide and addition of two cysteic acid residues per molecule, the radioactive material which eluted coincident with vasopressin both before and after this procedure was considered to be arginine vasopressin-'H. To our knowledge this is the first demonstration of in vitro biosynthesis of vasopressin by a tumor from a patient with SIADH.Ultrastructurally, the bronchogenic carcinoma was composed of small undifferentiated and granulated cells. The granulated neoplastic cells had well developed organelles (endoplasmic reticulum, free ribosomes) concerned with protein synthesis. Secretion granules present in the tumor cells were small, surrounded by a limiting membrane, and resembled those reported in polypeptide hormone-secreting cells.

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Section: Discussionmentioning

confidence: 97%

Biosynthesis of Vasopressin In Vitro and Ultrastructure of a Bronchogenic Carcinoma

George¹,

Capen²,

Phillips³

1972

J. Clin. Invest.

119

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“…This is particularly desirable when attempting to demon¬ strate that an antidiuretic material is vasopressin. Until recently (Berde, 1965), the rat without DI has been the standard preparation used to investigate the role of vasopressin in hyponatraemia associated with carcinoma of the bronchus (Lee et al 1964;Bower, Mason & Forsham, 1964;Barraclough, Jones & Lee, 1966). It is now clear that this assay is open to criticism since the NDI rat, even when waterloaded and anaesthetized with ethanol, is able to respond to neurohypophysial stimula¬ tion and although such a response is commonly of the all-or-none type, it is occasionally possible to obtain, at first, a small release of vasopressin and then by doubling the stimulus to induce a more massive release.…”

Section: Discussionmentioning

confidence: 99%

The Value of Rats With Hereditary Hypothalamic Diabetes Insipidus for the Bioassay of Vasopressin

Jones¹,

Lee²

1967

Journal of Endocrinology

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The pituitary glands of 11 rats (six females and five males, weighing 140\p=n-\200g.) with hereditary hypothalamic diabetes insipidus (DI) were found to contain oxytocin but no vasopressin.The DI rats could not always be distinguished from rats without diabetes insipidus (non-diabetes insipidus, NDI rats) by measurement of their daily urine volume.Stimulation of the neurohypophysis by fall in arterial pressure (haemorrhage, methacholine) or by nicotine, released vasopressin in NDI rats to produce a sustained antidiuresis, but in the DI rats there was only a transient fall in urine flow which did not outlast the hypotension.The DI rats were about twice as sensitive to vasopressin as NDI rats. As assay preparations they have the advantage that they cannot respond to vasopressin-releasing stimuli.Prolonged administration of Pitressin tannate in oil increased maximum urinary osmolality in DI rats, but failed to increase their sensitivity to intravenously injected vasopressin.

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“…Its pharmacological properties resemble those of arginine-vasopressin (Bower, Mason & Forsham, 1964;Lee, Jones & Barraclough, 1964;de Souza, Delaere & Berde, 1965;Barraclough et al, 1966;Godley & Locke, 1968). Other investigators have demonstrated immunological similarities between the tumour extract and vasopressin (Verherr et al, 1968).…”

Section: Discussionmentioning

confidence: 94%

Inappropriate antidiuretic hormone secretion associated with bronchial carcinoma, intracranial trauma and hypothyroidism: a diagnostic problem

MacLennan

1970

Postgraduate Medical Journal

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Bronchogenic Carcinoma with Inappropriate Antidiuretic Activity in Plasma and Tumor

Cited by 70 publications

References 22 publications

Biosynthesis of Vasopressin In Vitro and Ultrastructure of a Bronchogenic Carcinoma

Biosynthesis of Vasopressin In Vitro and Ultrastructure of a Bronchogenic Carcinoma

The Value of Rats With Hereditary Hypothalamic Diabetes Insipidus for the Bioassay of Vasopressin

Inappropriate antidiuretic hormone secretion associated with bronchial carcinoma, intracranial trauma and hypothyroidism: a diagnostic problem

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