Inappropriate antidiuretic hormone secretion associated with bronchial carcinoma, intracranial trauma and hypothyroidism: a diagnostic problem

Localization and Origin of Antidiuretic Principle in Para-Endocrine-Active Malignant Tumors

“…can be established, before clinical symptoms of inappropriate hormone secretion become evident leading to early tumor diagnosis. In one case with bronchogenic oat-cell carcinoma, clinical SIADH appeared 6 months before the tumor was finally diagnosed [14].…”

Para-Endocrine Tumor Activity with Emphasis on Ectopic ADH Secretion

“…This is in analogy to findings in patients with ACTH hypersecretion caused by a lung tumor (table 1); here the classical features of Cushing's syndrome are often absent, albeit plasma ACTH and cortisol levels are increased and hypokalemic alkalosis, hyperglycemia with glycosuria exist [47], Moreover, in patients with bronchial carcinoid tumors, in the absence of the clinical carcinoid syndrome, serotonin concentration was increased in the tumor extract [51], All these findings reinforce the view that diagnosis of ectopic hormone production in high risk subjects for lung cancer (heavy smokers beyond age 45-50, etc., see section IV) can be established before clinical syndromes of inappropriate hormone secretion become evident leading then to tumor diagnosis. In one case with bronchogenic oat cell carcinoma clinical SIADH appeared 6 months before the tumor was finally diagnosed [67].…”