Bronchodilator-Resistive Cough in Atopic Patients: Bronchial Reversibility and Hyperresponsiveness.

Fujimura, Masaki; Sakamoto, Sayuri; Matsuda, Tamotsu

doi:10.2169/internalmedicine.31.447

Cited by 72 publications

(70 citation statements)

References 12 publications

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“…The apparent contradiction between these two studies may result from difference of inhalation method: 15 s tidal breathing inhalation in our studies versus single breath inhalation in their study. The sex difference in cough reflexes may explain the greater susceptibility of females to coughing as a side effect of ACE inhibitors [1], and to chronic bronchodilator-resistant nonproductive cough associated with atopy (atopic cough) [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…Angiotensin-converting enzyme (ACE) inhibitors cause cough in 5-20% of patients who receive them, and females are more susceptible than males [1]. In addition, we have shown that chronic persistent nonproductive cough, resistant to bronchodilators, is more frequent in females [2,3]. Irritant receptors, and possibly C-fibre endings, are generally recognized as cough receptors in the airways [4,5].…”

mentioning

confidence: 99%

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Female gender as a determinant of cough threshold to inhaled capsaicin

Fujimura¹,

Kondo²,

Kamio³

et al. 1996

Eur Respir J

157

108

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Chronic, nonproductive cough and cough associated with the use of angiotensin converting enzyme inhibitors, are more frequently observed in females as compared to males.To examine the influence of sex, age, height, weight and pulmonary function on airway cough sensitivity, cough threshold to inhaled capsaicin, an index of the airway cough sensitivity, was measured in 160 nonsmoking, nonatopic healthy subjects. Forty young males (aged 24±2 yrs) 40 young females (aged 22±2 yrs) 40 middle-aged males (aged 48±5 yrs) and 40 middle-aged females (aged 50±7 yrs) were studied. The cough threshold was defined as the lowest concentration of inhaled capsaicin causing five or more coughs.The cough threshold was 3-5 fold lower in females than in males both in young (p<0.001) and middle-aged (p<0.005) subjects. Cough threshold was weakly but significantly correlated to height, weight, forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) when all subjects were considered together but not when each group was considered separately. Multiple regression analysis revealed that sex difference was the significant predictive factor for the cough threshold in either age group.These results confirm that cough sensitivity is heightened in females and suggest that influence of height and pulmonary function on the cough threshold may have resulted from sex difference.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Female gender as a determinant of cough threshold to inhaled capsaicin

Fujimura¹,

Kondo²,

Kamio³

et al. 1996

Eur Respir J

157

108

View full text Add to dashboard Cite

show abstract

“…In addition, it was shown recently that cough reflexing to capsaicin was more hypersensitive in females than in males, regardless of age, height, weight and pulmonary function [2]. The gender difference in cough sensitivity may explain why females are more susceptible to coughs induced by angiotensinconverting enzyme (ACE) inhibitors [3], and why chronic, persistent nonproductive cough which is resistant to bronchodilator therapy and in which eosinophils are detected in hypertonic saline-induced sputum [4], is more frequent in females [4][5][6].…”

mentioning

confidence: 99%

Atopy in cough sensitivity to capsaicin and bronchial responsiveness in young females

Fujimura

Kondo²,

Yasui³

et al. 1998

Eur Respir J

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We have shown previously that female sex is a determinant of cough sensitivity to inhaled capsaicin, but the relationship between atopy and the cough sensitivity has not been examined. The capsaicin cough threshold, defined as the lowest concentration of capsaicin causing five or more coughs, nonspecific bronchial responsiveness, defined as the provocative concentration of methacholine causing a 20% fall in the forced expiratory volume in one second (PC20), total immunoglobulin E (IgE) and specific IgEs to eight common aeroallergens (house dust 1, 2 and 6, Dermatophagoides pteronyssinus and D. farinae, Japanese cedar, ragweed and orchard grass) in the serum were measured in 71 nonsmoking, healthy young women aged 20.6+/-0.1 yrs (mean+/-EM). A structured interviewer-led questionnaire on allergic diseases revealed that one and six subjects had mild current and past asthma, respectively. These seven subjects were excluded from the data analysis. PC20 was significantly lower in 42 subjects showing a positive specific IgE than in 22 subjects showing a negative specific IgE to any of the eight allergens (p<0.05), while the capsaicin cough threshold was not significantly different between the subgroups. PC20 was significantly lower in subjects with positive specific IgE to Dermatophagoides and house dust, but not to the three kinds of pollen examined. It was confirmed that atopy indicated by specific immunoglobulin E to mite-related antigens, but not to pollen antigens, is associated with nonspecific bronchial responsiveness, and it is suggested that atopy is not a determinant of airway cough sensitivity in healthy, nonasthmatic subjects.

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“…5 CVA has been defined as chronic persistent cough without wheeze or rhonchi not due to any apparent causes and relief of coughing following bronchodilator therapy or inhaled steroid but not with antibiotics or antitussives. 6 Chronic cough is defined as cough lasting >3 weeks, but cough due to virus, mycoplasma infection and non-specific transient cough with even 8 weeks' d u ration can be excluded. 7,8 Among total 148 healthy patients complaining dry cough >8 weeks in this study, 79 (54%) were found having CVA.…”

Section: Discussionmentioning

confidence: 99%