Bronchodilator Effects of Dry Salbutamol Powder Administered by Rotahaler

Abstract

The bronchodilator effects of inhaled dry salbutamol powder (50, 100, 200 and 400 μg) have been compared in ten asthmatic patients with those of aerosolized salbutamol (200 μg) delivered from a standard pressurized inhaler. A dose of salbutamol powder (400 μg) produced greater bronchodilatation than 50, 100 or 200 μg of powder, but there was no significant difference between 400 μg of powder and 200 μg of aerosolized salbutamol. Powder administered by Rotahaler is well tolerated and offers several advantages over the pressurized aerosol canister.

Systematic review of clinical effectiveness of pressurised metered dose inhalers versus other hand held inhaler devices for delivering beta 2 agonists bronchodilators in asthma

“…26 35 38 One trial in children69 and one in adults47 showed that patients preferred the Turbohaler. One trial showed that patients preferred the pressurised metered dose inhaler to the multidose dry powder inhaler 81.…”

Airway deposition and airway effects of antiasthma drugs delivered from metered-dose inhalers

“…Rather conflicting results were obtained in a study where PEF was evaluated after administration of 50, 100, 200 and 400 µg of salbutamol with Rotahaler®, and 200 µg with pMDI [99]. The three low powder doses gave similar increases in PEF, whilst the 400 µg dose almost doubled the response.…”

Pharmacological Effects and Determination of the Morphological Distribution of Powder Aerosols Containing Fenoterol Hydrobromide and Ipratropium Bromide

“…J., 1968]. In 1977 two clinical re ports were published on salbutamol as a dry powder with lactose as a vehicle, in which the equal bronchospasmolytic ef fectiveness of powder and metered aerosol was demonstrated [Duncan et al, 1977;Hartley et al, 1975], Animal experiments are not known until now.…”