Bronchodilating and Uterine Activities of Ageratum conyzoides Extract

Achola, K. J.; Munenge, Rahab W.

doi:10.1076/phbi.36.2.93.4602

Cited by 23 publications

(14 citation statements)

References 7 publications

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“…Ageratum conyzoides plant extract inhibited uterine contractions induced by 5-hydroxytryptamine suggesting that the extract exhibited specific antiserotonergic activity on isolated uterus plant extract but had no effect on uterine contractions induced by acetylcholine [28,29]. The results support the popular use of the plant as a spasmolytic [28,29]. …”

Section: Resultsmentioning

confidence: 71%

Ethnomedicines used in Trinidad and Tobago for reproductive problems

Lans

2007

J Ethnobiology Ethnomedicine

166

105

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Background: Throughout history women have tried to control or enhance their fertility using herbal remedies, with various levels of societal support. Caribbean folk medicine has been influenced by European folk medicine, either through the early Spanish and French settlers or through the continuous immigration of Spanish-speaking peoples from Venezuela. Some folk uses are ancient and were documented by Galen and Pliny the Elder.

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Section: Resultsmentioning

confidence: 71%

Ethnomedicines used in Trinidad and Tobago for reproductive problems

Lans

2007

J Ethnobiology Ethnomedicine

166

105

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“…The percent DPPH was measured by using the following equation: DPPH scavenging effect (%) or Percent inhibition = A0 -A 1 / A0× 100. Where A0 was the Absorbance of control reaction and A1 was the Absorbance in the presence of the test or standard sample [33].…”

Section: Preparation Of Crude Extract and Its Fractionsmentioning

confidence: 99%

Antioxidant, antimicrobial activity and phytochemical analysis of the seeds extract of Cucumis sativus Linn

Begum

Asad

Sadiq

et al. 2018

PAB

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The prehistoric interaction of plants and human is being strengthened by the remarkable use of plants as remedy against diseases. Cucumis sativus L. is extensively cultivated globally including Pakistan. The present study was carried out to find the antioxidant, antimicrobial and phytochemical analysis of Cucumis sativus seed extract. Phytochemical analysis of ethanolic extract revealed the presence of flavonoids, terpenoids, tannins, cardiac glycoside, phenols and carbohydrates. 2,2-diphenyl-1-picrylhydrazyl (DPPH) method was used for antioxidant activity. Crude ethanolic extract showed maximum DPPH scavenging activity of 46.05±1.23 at 500µg/ml, while ascorbic acid showed 92.5%. For Antimicrobial activity against selected bacteria and fungi by agar well diffusion method was used. In the antibacterial activity, crude ethanolic extract was most active against Staphylococcus aureus (21.5mm) and less against Shigella flexneri (17.0mm). The n-haxane fraction was highly active against Salmonella typhi (26mm), DCM against E. coli (16.25mm) and Salmonella typhi showed 16.0mm inhibition with ethyl acetate. Crude extract of ethanol was tested against Alternaria, Acremonium, Verticellium, Pythium and Tricoderma sps. Alternaria showed low zone of inhibition (08mm) while the rest of fungi were highly susceptible with zone of inhibition 15mm, 14mm, 17mm and 15mm respectively. The Pythium spp. was highly susceptible to nhaxane fraction (20.00mm), Acremonium to DCM fraction (20.00mm) and to ethyl acetate (16.00 mm). The results showed significant antimicrobial and antioxidant activity which might be because of flavonoids, terpenoids, tannins and phenols in there, suggesting that C. sativus should be used as an active nutrition to control microbial infections leading to chronic diseases.

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“…15,16 In Nigeria, the leaves and roots are useful in the treatment of boils, leprosy, skin diseases, eye diseases, and inflammations. 17 It has been shown to possesses antidysentric, 18 fertility, 19 antispasmodic and muscle relaxation properties. 20 The leaves have been found to be a potential source of antidiabetic agents.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activities of Ethanolic Roots Extract of Ageratum Conyzoides on Alloxan-Induced Hepatic Damage in Diabetic Wistar Rats

et al. 2018

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Introduction The aim of the present study was to evaluate the hepatoprotective activities of the ethanolic roots extract of Ageratum conyzoides (AC) in alloxan-induced hepatic damage in diabetic rats. Materials and Methods Diabetes was induced in Wistar rats by the administration of alloxan (150 mg/kg, intraperitoneal). The ethanolic roots extract of AC, at doses of 250 and 500 mg/kg of body weight, was administered to diabetes-induced rats at a single dose per day for a period of 28 days. Results The effect of the ethanolic roots extract of AC on blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatic oxidative stress markers was measured in the diabetic rats. The ethanolic roots extract of AC exhibited significant reduction of blood glucose (p < 0.05) at the dose of 500 mg/kg when compared with the standard drug glibenclamide (600 µg/kg). The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels increased significantly (p < 0.05) in the diabetic group without treatment when compared with the control group. In addition, the levels of oxidative stress markers, such as superoxide dismutase (SOD), catalase (CT), glutathione peroxidase (GPx), and glutathione (GSH), were significantly decreased in the diabetic rats compared with the normal rats, while the lipid peroxidation significantly increased in the diabetic group without treatment compared with the control (normal) group. The results demonstrated that the morphological, functional and oxidative stress changes in the liver caused by the ingestion of alloxan were attenuated in diabetic rats treated with the ethanolic roots extract of AC. Conclusion We concluded that the ethanolic roots extract of AC possesses significant antidiabetic, antioxidant and hepatoprotective effects on alloxan-induced diabetic rats.

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Bronchodilating and Uterine Activities of Ageratum conyzoides Extract

Cited by 23 publications

References 7 publications

Ethnomedicines used in Trinidad and Tobago for reproductive problems

Ethnomedicines used in Trinidad and Tobago for reproductive problems

Antioxidant, antimicrobial activity and phytochemical analysis of the seeds extract of Cucumis sativus Linn

Hepatoprotective Activities of Ethanolic Roots Extract of Ageratum Conyzoides on Alloxan-Induced Hepatic Damage in Diabetic Wistar Rats

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