Bronchioloalveoläres Karzinom der Lunge assoziiert mit einem hochpositiven pANCA-Titer und dem klinischen Bild einer mikroskopischen Polyangiitis

Abstract

Autoimmune paraneoplastic processes are investigated in detail concerning the Lambert-Eaton-Myasthenic-Syndrome for bronchial carcinomas. For the cutaneous leukocytoclastic vasculitis as a non-ANCA-associated vasculitis the paraneoplastic genesis is described. Litttle is known about ANCA-associated vasculitis as a paraneoplastic autoimmune phenomenon. We present the case of a 62 year old woman referred to our hospital presenting air-space shadows mainly in both upper lobes, skin rash with petechial bleeding and a highly positive pANCA-titer. A bronchioloalveolar carcinoma was diagnosed by surgical biopsy. The patient developed renal failure postsurgically and died a few weeks after the diagnosis was established. This is the 5 (th) case in literature of the temporal concurrence of a bronchial carcinoma and an ANCA-associated vasculitis. So far only 24 cases of a solid tumor occuring simultaneously with an ANCA-positive vasculitis are reported in literature.

Evaluation of perinuclear antineutrophilic cytoplasmic antibodies in sera from dogs with inflammatory bowel disease or intestinal lymphoma

“…[22][23][24][25][26][27] Codevelopment of these antibodies and a neoplastic disease is rare, and the link between the 2 processes is not well defined. [22][23][24][25][26][27] Codevelopment of these antibodies and a neoplastic disease is rare, and the link between the 2 processes is not well defined.…”

“…[22][23][24][25][26][27] Codevelopment of these antibodies and a neoplastic disease is rare, and the link between the 2 processes is not well defined. 23,24,28 However, the mechanisms of development of neoplasia-associated vasculitis are complex and the paraneoplastic characteristic of the vasculitis is not constant. It has been suggested that the presence of these antibodies could be related to vasculitis that can develop as an autoimmune paraneoplastic process.…”

p-ANCA and c-ANCA frequency and their relationship with other diseases in patients with lung cancer

“…Toplam 24 hastada ise solid tümörlerle ilişkili ANCA pozitif vaskülit bildirilmiştir. 4 Baschinsky ve arkadaşları 66 yaşında nonsmoll cell ca (küçük hücreli olmayan akciğer ca) nedeni ile takip edilen ve p-ANCA pozitif pauci-immune crescentic vaskülit nedeni ile takip edilen ve renal yetmezlik nedeni ile ölen bir hasta bildirmişlerdir. 5 Morisako T. ve arkadaşlarının yaptığı çalışmada sol akciğerde kitle görünümü olan ve beraberinde sinüzit hikâyesi olan hastada p-ANCA pozitif olarak saptanmış, bu durum Wegener granülomatozisi'nin eşlik ettiği squamöz hücreli kanser olarak yorumlanmıştır.…”

Vasculitis de pequeño vaso en un paciente con un adenocarcinoma de colon

“…Se ha concedido importancia en la fisiopatogenia de las vasculitis a otros anticuerpos dirigidos contra constituyentes enzimáticos (proteinasa 3, elastasa, mieloperoxidasa, etc) del citoplasma de los neutrófilos (ANCA). De ellos, los p-ANCA con especificidad antimieloperoxidasa se relacionan con la variedad microscópica de la PAN y los c-ANCA dirigidos frente a la proteasa 3 con la enfermedad de Wegener 15 . Los pacientes pueden consultar por síntomas constitucionales tales como malestar general, astenia, pérdida de peso y fiebre.…”