Bronchiolitis Obliterans Organizing Pneumonia Associated with Systemic Lupus Erythematosus with Antiphospholipid Antibody.

Otsuka, Fumio; Amano, Tetsuki; Hashimoto, Naoko; Takahashi, Maki; Hayakawa, Nobuhiko; Makino, Hírofumi; Ota, Zensuke; Ogura, Toshio

doi:10.2169/internalmedicine.35.341

Cited by 30 publications

(26 citation statements)

References 10 publications

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“…In some patients it is associated with anti-JO-1 autoantibodies [324,326,333]. Organising pneumonia has also been reported in rheumatoid arthritis [158,[334][335][336][337], and more occasionally in systemic lupus erythematosus [338][339][340][341], scleroderma [342,343], CREST (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) syndrome with primary biliary cirrhosis [15,344], and Sjö gren syndrome [345,346]. Abundant buds of organising pneumonia have been reported in association with NSIP in a patient with scleroderma [347].…”

Section: Fungimentioning

confidence: 99%

Cryptogenic organising pneumonia

Jf¹

2006

European Respiratory Journal

477

466

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Organising pneumonia is defined histopathologically by intra-alveolar buds of granulation tissue, consisting of intermixed myofibroblasts and connective tissue. Although nonspecific, this histopathological pattern, together with characteristic clinical and imaging features, defines cryptogenic organising pneumonia when no cause or peculiar underlying context is found. Rapid clinical and imaging improvement is obtained with corticosteroid treatment, but relapses are common after stopping treatment.

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Section: Fungimentioning

confidence: 99%

Cryptogenic organising pneumonia

Jf¹

2006

European Respiratory Journal

477

466

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“…In these cases, the development of lung cysts should suggest the diagnosis of LIP [158][159][160]. Finally, the clinicoradiological syndrome of OP characterised by patchy alveolar infiltrates has been described in patients with SLE [161][162][163].…”

Section: Radiological Featuresmentioning

confidence: 99%

Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement

Antoniou¹,

Margaritopoulos²,

Economidou³

et al. 2009

European Respiratory Journal

148

122

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The connective tissue disorders (CTDs), also called collagen vascular diseases (CVDs), represent a heterogeneous group of immunologically mediated inflammatory disorders with a large variety of affected organs. Individuals with a CTD (rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, polymyositis/dermatomyositis and mixed connective tissue disease) are susceptible to respiratory involvement. When the lungs are affected, an increasing mortality and morbidity in CVDs occurs. Interstitial lung disease (ILD) is established as a clinical corollary across the spectrum of CTDs, with an overall incidence estimated at 15%.Therefore, pivotal clinical dilemmas remain in the evaluation and management of ILD involvement in CVDs. Critical questions are the presence of fibrosis and whether the disease is clinically significant. Moreover, the clinician has to decide if treatment is warranted and which is the best therapeutic approach. The use of additional tests, such as pulmonary function tests, high-resolution computed tomography scan, bronchoalveolar lavage fluid and surgical lung biopsy, deserves better discussion. The present review focuses on establishing the diagnosis of ILD in CTD, and on evaluating disease activity and prognosis. This will provide the basis for therapeutic decisions that will be discussed, including an overview of recent advances.

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“…Clinically, the disease resembles a flu-like syndrome of acute or subacute onset. In autoimmune diseases, BOOP has been reported to be associated with ankylosing spondylitis (8), a flareup stage of systemic lupus erythematosus (9), dermatomyositis (10), antiphospholipid syndrome (11), idiopathic thrombocytopenia purpura (12), rheumatoid arthritis (13), and systemic vasculitis, such as Wegener's granulomatosis. Only rare cases of BOOP associated with BD have been reported.…”

Section: Discussionmentioning

confidence: 99%

Bronchiolitis obliterans organizing pneumonia in a patient with Behçet's disease

Ning-Sheng

Chun-Liang²,

Ray-Sheng³

2004

Scandinavian Journal of Rheumatology

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A 55-year-old male presented a productive cough, haemoptysis, and intermittent fever for 2 weeks. He was diagnosed as having Behcet's disease (BD) with manifestations of recurrent oral ulcers, genital ulcers, erythema nodosum, a gastro/duodenal ulcer, colon ulcers, and folliculitis. After admission, a chest X-ray showed bilateral ill-defined patches. Subsequent chest computerized tomography revealed multiple patchy consolidations over the left and right lower lobes. Because of poor response to oxacillin antibiotic treatment, an open lung biopsy was arranged. Bronchiolitis obliterans organizing pneumonia (BOOP) was diagnosed. Methylprednisolone pulse therapy, followed by prednisolone and cyclophosphamide maintenance, was prescribed. The patient responded well, with clinical and radiological resolution. Early diagnosis with proper treatment is crucial in the management of this lethal pulmonary disease.

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Bronchiolitis Obliterans Organizing Pneumonia Associated with Systemic Lupus Erythematosus with Antiphospholipid Antibody.

Cited by 30 publications

References 10 publications

Cryptogenic organising pneumonia

Cryptogenic organising pneumonia

Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement

Bronchiolitis obliterans organizing pneumonia in a patient with Behçet's disease

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