Bronchiolar proliferation and metaplasia associated with thromboembolism.
            <i>A pathological and experimental study</i>

Berkheiser, S. W.

doi:10.1002/1097-0142(196302)16:2<205::aid-cncr2820160210>3.0.co;2-#

Cited by 29 publications

(7 citation statements)

References 4 publications

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“…Simple bronchiolarization may progress to adenomatous hyperplasia, adenoma (Figure 3), and adenocarcinoma. With more severe damage to the lower respiratory tract, simple bronchiolar- ization may be accompanied by squamous metaplasia (Figure 4) which i s a common response of the tracheobronchial epithelium to injury (Asmundsson et al, 1973;Berkheiser, 1963;Fukuda et al, 1989;Klein-Szanto et al, 1981). In the distal airways, this squamous metaplasia represents an adaptive response within the areas of bronchiolarization.…”

Section: Experimental Dust Overload (Intraluminal Dust Loading)mentioning

confidence: 99%

Comparative Pathology of Dust-Induced Pulmonary Lesions: Significance of Animal Studies to Humans

Schultz

1996

Inhalation Toxicology

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The proper interpretation of animal experiments on particulate materials i s essential in order to properly identify the relative risk associated with human exposure to these materials. This article reviews the pathology of experimental dust-induced pulmonary lesions, discusses factors necessary for the proper interpretation of these results, and makes recommendations for the design and conduct of future studies. In experimental studies, animals are often exposed to high concentrations of dusts that overwhelm normal lung clearance mechanisms, resulting in the somewhat poorly defined condition of "dust overload." The pulmonary response to this intra-alveolar dust loading is nonspecific and thus morphologically similar regardless of the dust type studied. In the rat, these lesions are characterized by alveolar macrophage accumulation, necrosis of pneumocytes, granuloma formation, fibrosis, and bronchiolarization and squamous metaplasia of alveoli. Depending on exposurz concentration and duration, bronchiolealveolar ademonas and adenocarcinomas and cystic keratinizing squamous lesions may occur. The squamous lesions appear to represent a response unique to the rat. The significance of studies using dust concentrations that produce these nonspecific lesions is questionable since such conditions, with extreme exception, do not occur in humans. Further, fibrogenic or carcinogenic properties that may be specific to a particular dust at exposure concentrations relevant to humans may actually be masked by the nonspecific response that occurs following dust overload. Studies with dust at concentrations that produce an interstitial dust loading but that are below the threshold for intra-alveolar dust overload are more relevant for human health hazard identification. This has been best demonstrated by the results of numerous studies with asbestos in rats where fibrosis and neoplasia, morphologically similar to that seen in humans, have been produced in the absence of the nonspecific lesions seen in dust overload. The interpretation of studies where dusts are administrated by nonconventional routes should also be undertaken with caution. for example, serosa tests bypass an important mechanistic step in fiber-induced mesothelioma, namely, the ability of a dust to reach the pleura surface following inhalation. In addition, such tests may produce diagnostic dilemmas since reactive changes on serosal surfaces, which are expected following application of any foreign substance, may be difficult to differentiate from a neoplastic response. Future studies to assess the human health hazards of fibrous and nonfibrous dusts should be conducted at concentrations that allow for the characterization of responses specific to a given dust and by exposure routes most representative of that experienced by humans.

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Section: Experimental Dust Overload (Intraluminal Dust Loading)mentioning

confidence: 99%

Comparative Pathology of Dust-Induced Pulmonary Lesions: Significance of Animal Studies to Humans

Schultz

1996

Inhalation Toxicology

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“…Previous studies have established that adenomatous proliferation of terminal bronchiolar epithelium is a reaction frequently associated with fibrosis and nonspecific inflammation resulting from either anthracosis, pulmonary infarction, or other chronic lung disease.3. 4 The relatively low incidence of adenomatous hyperplasia in both the cortisone series of human cases and in the experimental animals (8% and 6% respectively) indicates that fibrosis and inflammation were probably not important factors in the production of the pulmonary epithelial hyperplasias observed in the present study. The relatively high incidence of alveolar cell hyperplasia and epidermal metaplasia, 2 reactions not previously observed, also suggests that the aforementioned factors are not responsible for the production of these particular metaplasias.…”

Section: Disccssicinmentioning

confidence: 47%

Epithelial proliferation of the lung associated with cortisone administration.A pathological and experimental study

Berkheiser

1963

Cancer

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“…24 However, false-positive results can occur in the setting of active infectious or inflammatory processes. [18][19][20][21] CONCLUSIONS Pulmonary infarctions can simulate the clinicoradiological features of lung cancer, an association not reported previously, to our knowledge. 15 Pulmonary infarctions have been associated with malignant-appearing cells in respiratory secretions.…”

Section: Resultsmentioning

confidence: 80%

“…In contrast, pulmonary infarction takes several months to resolve and may leave a linear scar. [18][19][20][21] The adjacent pleural surface is frequently covered by a fibrinous exudate (pleuritis). 17 Their size may vary widely, from barely visible to involvement of nearly an entire lobe.…”

Section: Resultsmentioning

confidence: 99%

Clinicoradiological Features of Pulmonary Infarctions Mimicking Lung Cancer

George¹,

Tazelaar

Swensen

et al. 2004

Mayo Clinic Proceedings

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Bronchiolar proliferation and metaplasia associated with thromboembolism. A pathological and experimental study

Cited by 29 publications

References 4 publications

Comparative Pathology of Dust-Induced Pulmonary Lesions: Significance of Animal Studies to Humans

Comparative Pathology of Dust-Induced Pulmonary Lesions: Significance of Animal Studies to Humans

Epithelial proliferation of the lung associated with cortisone administration.A pathological and experimental study

Clinicoradiological Features of Pulmonary Infarctions Mimicking Lung Cancer

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