Epithelial proliferation of the lung associated with cortisone administration.A pathological and experimental study

Berkheiser, S. W.

doi:10.1002/1097-0142(196310)16:10<1354::aid-cncr2820161016>3.0.co;2-l

Cited by 12 publications

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Lung Changes and Chemotherapeutic Agents in Childhood

Rodin¹

1970

Am J Dis Child

View full text Add to dashboard Cite

Extensive atypical proliferation of alveolar lining cells was found at autopsy on a child dying in respiratory distress while receiving cyclophosphamide and vincristine. Lungs were heavy and uniformly consolidated. Microscopic study revealed highly atypical cells filling alveolar spaces and lining alveoli and some bronchioles. These changes are compatible with those previously described in adults treated with busulfan, which like

show abstract

Lung Changes and Chemotherapeutic Agents in Childhood

Rodin¹

1970

Am J Dis Child

View full text Add to dashboard Cite

show abstract

Atypias of bronchiolar epithelium associated with 6-mercaptopurine (6-MP) and triethylene melamine (TEM).An experimental study

Berkheiser

1967

Cancer

Self Cite

View full text Add to dashboard Cite

The pathologic and experimentally induced epithelial atypias in the lung associated with 6‐MP and TEM were investigated. Twenty‐five rabbits were given 12.5 mg of 6‐MP per week and 25 rabbits were given 1.25 mg of TEM per week. The drugs were inserted directly in the stomach by a nasal‐gastric tube. Five additional rabbits were given combined doses of both drugs per week. A control group of 50 rabbits was maintained on a standard diet. TEM produced the highest incidence of basal cell atypia (44%) but the incidence of squamous cell atypia was approximately the same in the 6‐MP and TEM series (4%). The peak incidence of atypias in both series occurred in the 3 to 6‐month period. Combined administration of 6‐MP and TEM did not produce any demonstrable additive effects on bronchiolar epithelium. A relatively high incidence of plumonary vascular hyperplasia was associated with both agents (40% with 6‐MP, and 20% with TEM). The author suggests that local anoxia may be an important contributing factor in the experimental production of epithelial atypias. The experimentally induced epithelial atypias were basically similar to those noted in humans after treatment with various antileukemic agents.

show abstract

Ultrastructure of pulmonary bleomycin toxicity

Bedrpssian

Luna

Mackay

et al. 1973

Cancer

View full text Add to dashboard Cite

Three cancer patients developed pulmonary distress during treatment with bieomycin. Light microscopic examination of lung tissue obtained by percutaneous biopsy revealed a diffuse alveolar damage progressing to interstitial pneumonitis. With electron microscopy, interstitial adema and collagen deposition, accumulation of fibroblasts, disappearance of type I, and proliferation of type II alveolar epithelial cells were noted. Alveoli contained proteinaceous material and a mixture of macrophages and type II cells. A peculiar alteration was noted in some type II cells consisting of shortening of the microvilli and extrusion of cytoplasmic lamellar bodies with possible surfactant impairment. These findings are consistent with the drug's effect upon the alveolar epithelium. Bleomycin, therefore, can be considered another etiologic agent of iatrogenic interstitial pneumonitis.

show abstract

Epithelial proliferation of the lung associated with cortisone administration.A pathological and experimental study

Cited by 12 publications

References 14 publications

Lung Changes and Chemotherapeutic Agents in Childhood

Lung Changes and Chemotherapeutic Agents in Childhood

Atypias of bronchiolar epithelium associated with 6-mercaptopurine (6-MP) and triethylene melamine (TEM).An experimental study

Ultrastructure of pulmonary bleomycin toxicity

Contact Info

Product

Resources

About