Bronchial Reactivity in Diabetic Patients

Villa, Maria Pia; Cacciari, E; Bernardi, Filippo; Cicognani, Alessandro; Salardi, S; Zapulla, Franco

doi:10.1001/archpedi.1988.02150070040021

Cited by 37 publications

(4 citation statements)

References 27 publications

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“…The functional pattern described by this study was consistent with decreased lung elastic recoil, caused by prolonged hyperglycemia resulting in excessive non-enzymatic glycosylation of connective tissue [27,46,47], and with diminished elasticity. This is because FVC was impaired and the RV/TLC ratio was higher than in controls (p = 0.0002), even at the onset of disease (p = 0.04), without evidence of reduced FEV1/FVC or TLC.…”

Section: Pulmonary Function In Children and Adolescents With T1dsupporting

confidence: 79%

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The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

et al. 2021

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Historically, the lung was not listed and recognized as a major target organ of diabetic injury. The first evidence of diabetic lung involvement was published fifty years ago, with a study conducted in a population of young adults affected by type 1 diabetes (T1D). In recent years, there has been mounting evidence showing that the lung is a target organ of diabetic injury since the beginning of the disease—at the pediatric age. The deeply branched vascularization of the lungs and the abundance of connective tissue, indeed, make them vulnerable to the effects of hyperglycemia, in a way similar to other organs affected by microvascular complications. In this review, we focus on pulmonary function impairment in children and adolescents affected by T1D. We also cover controversial aspects regarding available studies and future perspectives in this field.

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Section: Pulmonary Function In Children and Adolescents With T1dsupporting

confidence: 79%

“…Similarly, the reduction of FEV1 initially reported by Cazzato and Villa [46], was not confirmed by later studies conducted by Verrotti, Van Gelt, Al Saadi, and Villa himself [39,41,43].…”

Section: Pulmonary Function In Children and Adolescents With T1dmentioning

confidence: 77%

The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

et al. 2021

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“…[19] Autonomic and phrenic neuropathy causing alterations in bronchial reactivity and respiratory muscle function was also suggested in one study. [23]…”

Section: Discussionmentioning

confidence: 99%

Pulmonary functions in patients with diabetes mellitus

et al. 2011

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Background:A reduction in lung capacity has been reported previously among diabetics. According to WHO estimates, Pakistan is currently eighth in the prevalence of diabetes mellitus (DM) and will become fourth by the year 2025 with over 15 million individuals. This study was designed to see the impairment of lung functions on spirometry in DM patients.Objective:Our aim was to investigate the pulmonary functions tests of Pakistani patients with DM.Materials and Methods:Between January to July 2004, 128 subjects who were never-smokers and had no acute or chronic pulmonary disease were recruited. Sixty-four of these subjects had DM and 64 were healthy matched controls. All underwent screening with detailed history, anthropometry, lipid profile, and spirometric measurements at the Aga Khan University Hospital, Karachi, Pakistan.Results:The mean age of diabetics and matched control were 54.3±9 and 54.0±8 (P<0.87) years, respectively. Diabetes patients showed a significant reduction in the forced vital capacity (FVC) [mean difference (95% CI) – 0.36 (–0.64, –0.07) P<0.01], forced expiratory volume in one second (FEV1) [– 0.25(–0.50, –0.003) P<0.04], and slow vital capacity (SVC) [– 0.28(–0.54, –0.01) P<0.04], relative to nondiabetic controls. There was no significant difference noted in the forced expiratory ratio and maximum mid-expiratory flow between the groups. There was also a significant higher level of triglycerides noted among diabetics (P<0.001).Conclusion:Diabetic patients showed impaired lung function independent of smoking. This reduced lung function is likely to be a chronic complication of diabetes mellitus.

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“…Decrease in FEV, is expressed as percentage of predicted (pred) FEV,. 30/15, ratio of 30th R-R interval to 15th R-R interval after moving from supine to erect posture; Rs, Spearman's rank correlation coefficient; • , diabetic patients without cardiac autonomic dysfunction (CAD); O, diabetic patients with CAD.children with IDDM compared with nondiabetic control children has been reported(17). Carbachol and methacholine are stable analogues of acetylcholine that directly act on bronchial smooth muscle, and methacholine challenge ap-Correlation between deep breathing-induced heart-rate changes (maximum -minimum heart rate) and forced expiratoryvolume in 1 s (FEV,) on methacholine challenge in diabetic patients.…”

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confidence: 99%

Decreased Bronchial Response to Methacholine in IDDM Patients With Autonomic Neuropathy

Bertherat

Lubetzki²,

Lockhart³

et al. 1991

Diabetes

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This study was designed to evaluate the involvement of airways innervation during diabetic autonomic neuropathy. Bronchial response to methacholine was assessed by inhalation of serially doubling doses in 22 insulin-dependent diabetes mellitus (IDDM) patients and 11 nondiabetic control subjects selected for their nonsmoking habits. Cardiovascular autonomic control was studied by four standardized tests, i.e., blood pressure and heart-rate variations during orthostatism, heart-rate variation during Valsalva maneuver, and deep breathing. Magnitude and time-course of response to methacholine were similar in nondiabetic subjects and IDDM patients without any abnormal result on cardiovascular tests. Conversely, bronchial response to methacholine was markedly reduced in IDDM patients with one or more abnormal results by cardiovascular assessment of autonomic control. In the IDDM patients, bronchial response to methacholine was significantly correlated to indexes of cardiovascular autonomic control. These results suggest that, during diabetic neuropathy, innervation of the airways likewise involves cardiac autonomic control and leads to impairment of defense reflexes of the airways.

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Bronchial Reactivity in Diabetic Patients

Cited by 37 publications

References 27 publications

The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

Pulmonary functions in patients with diabetes mellitus

Decreased Bronchial Response to Methacholine in IDDM Patients With Autonomic Neuropathy

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