Pulmonary functions in patients with diabetes mellitus

Abstract

Background:A reduction in lung capacity has been reported previously among diabetics. According to WHO estimates, Pakistan is currently eighth in the prevalence of diabetes mellitus (DM) and will become fourth by the year 2025 with over 15 million individuals. This study was designed to see the impairment of lung functions on spirometry in DM patients.Objective:Our aim was to investigate the pulmonary functions tests of Pakistani patients with DM.Materials and Methods:Between January to July 2004, 128 subjects who were never-smokers and had no acute or chronic pulmonary disease were recruited. Sixty-four of these subjects had DM and 64 were healthy matched controls. All underwent screening with detailed history, anthropometry, lipid profile, and spirometric measurements at the Aga Khan University Hospital, Karachi, Pakistan.Results:The mean age of diabetics and matched control were 54.3±9 and 54.0±8 (P<0.87) years, respectively. Diabetes patients showed a significant reduction in the forced vital capacity (FVC) [mean difference (95% CI) – 0.36 (–0.64, –0.07) P<0.01], forced expiratory volume in one second (FEV1) [– 0.25(–0.50, –0.003) P<0.04], and slow vital capacity (SVC) [– 0.28(–0.54, –0.01) P<0.04], relative to nondiabetic controls. There was no significant difference noted in the forced expiratory ratio and maximum mid-expiratory flow between the groups. There was also a significant higher level of triglycerides noted among diabetics (P<0.001).Conclusion:Diabetic patients showed impaired lung function independent of smoking. This reduced lung function is likely to be a chronic complication of diabetes mellitus.

Study on comparison of pulmonary function tests among diabetic and non-diabetic patients in a tertiary care hospital

“…However there was mild reduction in FEV1/FVC which was not statistically significant. The findings were similar to those reported by Irfan et al and Klein et al 5,6 Study conducted by Davis et al also demonstrated that VC, FVC, FEV1 and PEF were decreased in type 2 diabetic patients. 9 Non enzymatic glycosylation induced alteration of lung connective tissue is one of the most likely underlying mechanism which is being investigated for restrictive lung disorder.…”

“…This is similar to the study published by Irfan M et al where the mean age was 54.3. 5 The proportion of females was 42% (n = 21) in the study group and 44% (n = 22) in the control group. The mean Body Mass Index of the study group was 23.88±3.47 kg/m 2 and the control group was 23.27±4.27kg/m 2 , (P = 0.4388).…”

Diabetic: A Comparative Study

“…40 percent female with diabetes mellitus [16]. Another study by Irfan et al [17] published on 2011 has taken 42 percent of female with diabetes showing similar group division as in our study.…”

“…"Pulmonary function test in type 2 diabetes mellitus and their association with glycemic control and duration of diabetes mellitus" a study by Shah et al [18] also has taken a subject with mean age of 53.90± 8.45 Vs 54.88±8.28 among diabetic and non diabetics. Other study by Zeneldin et al [19] published in 2015 and Irfan et al also had higher mean age among the control subjects [17]. Anandhalakshmi S et al [20] and El-Habashy MM et al (2013) [21] scrutinized that in both diabetic and non-diabetic group mean age of the patients was younger (44.8± 8.9 vs. 39.4 ± 11.7), due to small sample size these studies showed dissimilar results.…”

Lungenfunktion bei älteren Probanden mit metabolischem Syndrom und Typ-2-Diabetes

“…Vorangegangene Studien zeigten, dass kardiovaskuläre Risikofaktoren sowohl bei Rauchern als auch bei Nichtrauchern in Verbindung mit Verände-rungen der Lungenfunktion stehen kön-nen. So vermag die gestörte Glucosetoleranz ebenso wie der T2D mit einer pulmonalen Funktionseinschränkung einherzugehen [19,26,51]. Dabei konnte neben einer erhöhten Prävalenz von OLD eine Verringerung von FEV 1 und FVC bzw.…”