Bronchial Epithelial Calcium Metabolism Impairment in Smokers and Chronic Obstructive Pulmonary Disease. Decreased ORAI3 Signaling

Petit, Audrey; Knabe, Lucie; Khelloufi, Kamel; Jory, Myriam; Gras, Delphine; Cabon, Yann; Begg, Malcolm; Richard, Sylvain; Massiera, Gladys; Chanez, Pascal; Vachier, Isabelle; Bourdin, Arnaud

doi:10.1165/rcmb.2018-0228oc

Cited by 20 publications

(18 citation statements)

References 58 publications

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“…The function of the cilia is to clear the mucus from smaller airways once damaged the mucus is not cleared resulting in clogging of the airways and decrease in lung capacity. (11) This will again help COVID 19 symptoms to increase in severity. An emerging concept related to ACE2 gene expression which are present on type II pneumocytes of the lungs has become popular in COVID-19 infections.…”

Section: Tobacco Consumers and Covid 19 Diseasementioning

confidence: 97%

Tobacco: An invisible and immediate threat for COVID 19

Garg

Deshmukh

2020

Indian J Community Health

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One of the major steps to prevent damage due to any pandemic is to focus on risk factors related to the disease. Tobacco consumption is emerging as a major factor out of all for COVID 19. There is hardly any country who has warned the public about this or has made the Tobacco control measures stringent in view of COVID 19. Factors making tobacco consumers more vulnerable to COVID 19 infections are low immunity, damaged cilia in smaller air ways leading to decreased lung capacity and previous history of respiratory illness. Smokers have more expression of ACE2 receptor gene which is also responsible for SARS-COV-2 virus replication in host. More viral load makes smokers potent “carrier”. COVID 19 can be transmitted via tobacco consumers by sharing of smoked tobacco and release of vapour droplets. Spitting of smokeless tobacco in public places puts community at risk. Cardiovascular diseases and cancers caused by tobacco consumption act as comorbidities aggravating the symptoms in COVID 19 infection. Scope of FCTC framework can be extended to address prevention and control of COVID 19. Recommendations: tobacco products should be banned immediately to control the spread. MPOWER strategy of FCTC can be utilized in this pandemic to prevent transmission.

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Section: Tobacco Consumers and Covid 19 Diseasementioning

confidence: 97%

Tobacco: An invisible and immediate threat for COVID 19

Garg

Deshmukh

2020

Indian J Community Health

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“…Nicotine, as a standard component of cigarette smoke, induces bronchial epithelial cell senescence and apoptosis via ROS-mediated impairment of autophagy ( Bodas et al, 2016 ). The Ca 2+ reservoir in the ER is decreased in chronic obstructive pulmonary disease patients, and the Ca 2+ influx is suppressed in epithelial cells from smokers ( Petit et al, 2019 ; Figure 7 ). The following mechanism, based on a study of mice and cultured cells, may explain this phenomenon.…”

Section: Smokingmentioning

confidence: 99%

Mitochondrial Contact Sites in Inflammation-Induced Cardiovascular Disease

Líu

Liu

Zhuang

et al. 2020

Front. Cell Dev. Biol.

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The mitochondrion, the ATP-producing center, is both physically and functionally associated with almost all other organelles in the cell. Mitochondrial-associated membranes (MAMs) are involved in a variety of biological processes, such as lipid exchange, protein transport, mitochondrial fission, mitophagy, and inflammation. Several inflammation-related diseases in the cardiovascular system involve several intracellular events including mitochondrial dysfunction as well as disruption of MAMs. Therefore, an in-depth exploration of the function of MAMs will be of great significance for us to understand the initiation, progression, and clinical complications of cardiovascular disease (CVD). In this review, we summarize the recent advances in our knowledge of MAM regulation and function in CVD-related cells. We discuss the potential roles of MAMs in activating inflammation to influence the development of CVD.

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“…Merokok dapat mengganggu sinyal kalsium yang disebabkan penipisan simpanan endoplasma, penurunan pelepasan kalsium retikulum endoplasma (RE), serta terjadi reaksi gen, dalam hal ini yaitu ORAI3. 7 Hal ini berlawanan dengan fungsi kalsium yang merupakan pembawa pesan utama dalam semua fungsi fisiologis terutama fungsi pernafasan yaitu mucus, sekresi citokin, cilia, dan perbaikan epitel. 8 Makrofag alveolar pada PPOK telah menunjukan gangguan fagositosis bakteri dan sekresi sitokin yang tidak teratur dan bergantung oleh proses kalsium.…”

Section: Pendahuluanunclassified

Korelasi antara Kadar Kalsium Serum dengan Fungsi Paru pada Penderita Penyakit Paru Obstruksi Kronik (PPOK)

R.Ahmad

Santoso

Qanitha

2020

JIKM

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AbstrakPatologi PPOK menunjukkan gangguan inflamasi kronis yang dapat menyebabkan penyumbatan aliran udara di paruparu, sedangkan kalsium diketahui memiliki kemampuan mengembalikan aspek respon bawaan. Kalsium juga memiliki peran dalam proses pergerakan otot pernapasan sebagai kompensasi untuk hambatan aliran udara. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar kalsium serum dan fungsi paru pada pasien dengan PPOK. Penelitian ini menggunakan desain cross-sectional dengan analitik observasional, dilakukan selama 2 bulan, dengan total sampel 36 orang pasien PPOK. Berdasarkan hasil analisis data, diketahui bahwa tidak ada hubungan antara kadar kalsium serum dengan fungsi paru pada pasien PPOK (P> 0,05). Diperlukan penelitian lebih lanjut dengan sampel yang lebih besar dan penelitian dengan menggunakan variabel lebih spesifik seperti serum ion kalsium. Kata Kunci : Fungsi paru, kalsium serum, PPOK Abstract Pathology of COPD shows chronic inflammatory disorders that can cause blockage of air flow in the lungs, while calcium is known to have the ability to restore the innate response aspect, calcium also has a role in the process of breathing muscle movement as compensation for air flow obstruction. This study aims to determine the relationship between serum calcium levels and lung function in patients with COPD. This study used a cross-sectional design with observational analytics, conducted for 2 months, with a total sample of 36 COPD patients. Based on the results of data analysis, it is known that there is no relationship between serum calcium levels with lung function in COPD patients (P> 0.05). Further research is needed with a larger sample and research using a more specific variable, serum calcium ion.

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Bronchial Epithelial Calcium Metabolism Impairment in Smokers and Chronic Obstructive Pulmonary Disease. Decreased ORAI3 Signaling

Cited by 20 publications

References 58 publications

Tobacco: An invisible and immediate threat for COVID 19

Tobacco: An invisible and immediate threat for COVID 19

Mitochondrial Contact Sites in Inflammation-Induced Cardiovascular Disease

Korelasi antara Kadar Kalsium Serum dengan Fungsi Paru pada Penderita Penyakit Paru Obstruksi Kronik (PPOK)

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