Bronchial Carcinoma Treated with Nitrogen Mustard and Cyclophosphamide

Barran, Katharine M.; Helm, W. H.; King, D. A.

doi:10.1136/bmj.2.5463.685

Cited by 19 publications

References 6 publications

(4 reference statements)

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Intensive combined chemotherapy and radiotherapy in patients with nonresectable bronchogenic carcinoma

Hansen¹,

Muggia²,

Andrews³

et al. 1972

Cancer

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A treatment program utilizing combinations of antineoplastic agents was evaluated in 46 unresectable untreated patients with bronchogenic carcinoma. Following specific staging procedures, patients considered to have “limited” disease apparently confined to one hemithorax and ipsilateral supraclavicular area were treated, in addition, with cobalt‐60 radiotherapy, receiving 5000 R in a 6‐week period. The median survival for patients with “limited” disease was 13 months with 9 of 27 patients (33%) currently alive, vs. 4 months for patients with “extensive” disease and with 2 of 17 patients (12%) still alive. Determination of objective response to the combined treatment was possible in 36 patients, and it occurred in 22 (61%). Responders lived significantly longer (median 365 days) than nonresponders (median 130 days). The objective response rate was highest and the survival longest in patients with adenocarcinoma and small cell undifferentiated carcinoma of the lung. The data suggest that the principle of staging and treatment as utilized in the current study might have a place in the management of inoperable lung cancer and contribute to the prolongation of survival.

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Intensive combined chemotherapy and radiotherapy in patients with nonresectable bronchogenic carcinoma

Hansen¹,

Muggia²,

Andrews³

et al. 1972

Cancer

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Combination chemotherapy and radiation therapy in small cell carcinoma of the lung

Eagan

Maurer

Forcier

et al. 1973

Cancer

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Oat cell carcinoma of the lung.Early treatment results of combination radiation therapy and chemotherapy

Hornback

Einhorn

Shidnia

et al. 1976

Cancer

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Since August 1974, 50 patients with histologically proven oat cell carcinoma of the lung were treated at Indiana University Hospitals with a combination of adriamycin, cyclophosphamide, Oncovin, BCG immunotherapy, and radiation therapy to the primary lung tumor and whole brain. Twenty‐nine patients are eligible for a 6‐month follow‐up and are included in this report. All 29 patients responded to therapy; 12 patients (41%) had a minimum of 50% reduction in tumor mass and 17 patients (59%) had complete clinical remission of disease. Eight (38%) of the 29 patients have remained in complete remission from 6 to 14 months, and 90% of the patients survived a minimum of 6 months. This represents a considerable improvement in survival rates over what had been obtained at Indiana University Hospitals previously.

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Bronchial Carcinoma Treated with Nitrogen Mustard and Cyclophosphamide

Cited by 19 publications

References 6 publications

Intensive combined chemotherapy and radiotherapy in patients with nonresectable bronchogenic carcinoma

Intensive combined chemotherapy and radiotherapy in patients with nonresectable bronchogenic carcinoma

Combination chemotherapy and radiation therapy in small cell carcinoma of the lung

Oat cell carcinoma of the lung.Early treatment results of combination radiation therapy and chemotherapy

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