Bronchial carcinoid tumors: nodal status and long-term survival after resection

Cardillo, Giuseppe; Sera, Francesco; Martino, Marco; Graziano, Paolo; Giunti, Roberto; Carbone, Luigi; Facciolo, Francesco; Martelli, Maria Paola

doi:10.1016/j.athoracsur.2003.10.089

Cited by 207 publications

(185 citation statements)

References 20 publications

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“…Beasley et al found that increased numbers of mitoses, tumor size >3.5 cm, and female gender were negative predictors of survival, whereas smoking was not (3). The same is found in several other studies regarding smoking (12,13). In the present study, survival was associated with gender, Ki67-index, and metastatic disease at diagnosis.…”

Section: Discussionsupporting

confidence: 74%

“…Patients had a similar distribution of age, gender, and tumor type compared with previous studies. (4,8,9,13,20). Hence, they were representative of the population with bronchial carcinoids.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies concluded that smoking was not associated with bronchial carcinoid development, whereas two other studies found higher smoker prevalence among AC patients compared to healthy individuals or patients with TC (8-11). An association between smoking status and survival has not been demonstrated (3,9,12,13). Other predictors of mortality are histological type and stage at diagnosis (3, 9), whereas female gender was a negative predictor in one study (3).…”

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confidence: 99%

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Survival and Predictors of Death for Patients with Bronchopulmonary Carcinoid at a Danish Tertiary NET Centre

Kornerup

Dam

Grønbæk

2017

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Abstract. Background/Aim: Bronchopulmonary carcinoids comprise of typical carcioids (TC) and atypical carcinoids (AC). We present characteristics and associated mortality in patients with TC and AC followed-up Bronchopulmonary neuroendocrine tumors (BP-NETs) account for 20-25% of all neuroendocrine tumors and 20-25% of all lung cancer. BP-NETs comprise of typical carcinoids (TC), atypical carcinoids (AC), large-cell neuroendocrine carcinomas (LCNEC) and small-cell lung carcinomas (SCLC). Bronchial carcinoids (TC 80%, AC 20%) represent 1-2%, LCNEC <1%, and SCLC 10% of all lung cancer (1-4). TCs are considered low-grade and ACs intermediate-grade NETs while LCNECs and SCLCs are high-grade. Survival rates for each subtype reflect these differences. Five-year survival in a retrospective study of 12,345 patients diagnosed with BP-NET between 1978-1997 was 87% for TC, 44% for AC, 15% for LCNEC, and 2% in SCLC (5). However, other studies described 5-year survival of 87-100%, 61-88%, 15-57% and <5% for TC, AC, LCNEC and SCLC, respectively (1-3).Studies on cytogenetics found distinct chromosomal imbalances in BP-NET but to a lesser degree than SCLC. Genetic alterations were less widespread and involved narrower gene regions in BP-NET compared to SCLC, but several alterations were identical for both BP-NET and SCLC (6, 7).Studies investigating an association between smoking and development of AC and TC are conflicting. Several studies concluded that smoking was not associated with bronchial carcinoid development, whereas two other studies found higher smoker prevalence among AC patients compared to healthy individuals or patients with TC (8-11). An association between smoking status and survival has not been demonstrated (3,9,12,13). Other predictors of mortality are histological type and stage at diagnosis (3, 9), whereas female gender was a negative predictor in one study (3).The aim of the present study was to describe demographic, immunohistochemical, and biochemical characteristics, survival, and predictors of death for all patients diagnosed with bronchial carcinoid and referred to our

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Survival and Predictors of Death for Patients with Bronchopulmonary Carcinoid at a Danish Tertiary NET Centre

Kornerup

Dam

Grønbæk

2017

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“…Hence, it can been seen that the survivals of patients with LCNEC and SCLC were slightly better. Different from the previous reports (Fink et al, 2001;Ferguson et al, 2002;Filosso et al, 2002;Cardillo et al, 2004), the histological subtype did not provide the accurate prediction of prognosis according to multivariate analysis. The results in this study revealed that age, TNM staging and treatment were confirmed to be independent prognostic factors that conditioned the long-term survival.…”

Section: Discussioncontrasting

confidence: 53%

Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors

Hu²,

Sun³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Indeed, differentiation of GEP NET classified as poorly compared with well-differentiated (WD) carcinoma (Johnson et al 1986, Greenberg et al 1987, Madeira et al 1998, Travis et al 1998, Rindi et al 1999, Lim et al 2005, Panzuto et al 2005, Asamura et al 2006, Faggiano et al 2007, Lepage et al 2007, Pape et al 2008 and stage (Lo et al 1996, Pelosi et al 1996, Burke et al 1997, Madeira et al 1998, Kirshbom et al 1999, Rindi et al 1999, Shebani et al 1999, Onaitis et al 2000, Quaedvlieg et al 2001, Rigaud et al 2001, Solorzano et al 2001, Hochwald et al 2002, Plöckinger et al 2004, Panzuto et al 2005, Tomassetti et al 2006, Baudin 2007, Pape et al 2008 as long been recognized the strongest prognostic parameters before the primary location. More recently, lymph node metastases (Hellman et al 2002, Cardillo et al 2004, Lim et al 2005, Tomassetti et al 2005, Baudin 2007, García-Yuste et al 2007, Rea et al 2007, Pape et al 2008 and proliferative index have emerged as major determinant of prognosis in GEP tumors of the lung (Travis et al 1998, Beasley ...…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors influencing survival from metastatic (stage IV) gastroenteropancreatic well-differentiated endocrine carcinoma

Durante¹,

Boukheris²,

Dromain³

et al. 2009

Endocrine-Related Cancer

104

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Survival of metastatic gastroenteropancreatic well-differentiated endocrine carcinoma (GEP WDEC) is not well characterized. We evaluated the long-term outcome and prognostic factors for survival in 118 patients with distant metastases from GEP WDEC. Inclusion criteria were 1) pathological review by a single pathologist according to the present WHO criteria, 2) absence of previous therapy apart from surgery, 3) complete morphological evaluation within 3 months including somatostatin receptor scintigraphy, and 4) follow-up at Gustave-Roussy Institute until death or study's end. Clinical, biological marker, and pathological parameters were analyzed in univariate and multivariate statistical models. Survival after the first complete imaging work-up of the metastatic disease was determined using Kaplan-Meier method. Overall, survival for 5 years after the diagnosis of metastatic disease was 54%. In multivariate analysis, age (hazard ratio (HR): 1.05, 95% confidence interval (CI): 1.01-1.08, PZ0.01), the number of liver metastases (HR: 3.4, 95% CI: 1.4-8.3, PZ0.01), tumor slope (HR: 1.1, 95% CI: 1.0-1.1, PZ0.001), and initial surgery (HR: 0.3, 95% CI: 0.1-0.8, PZ0.01) were predictive of survival. Five-year survival was 100%, 91% (95% CI, 51-98%), 62% (95% CI, 37-83%), and 9% (95% CI, 6-32%) when patients had 0, 1, 2, 3 or more poor prognostic features respectively. This study enables the stratification of metastatic GEP WDEC patients into distinct risk groups. These risk categories can be used to tailor therapeutic approaches and also to design and interpret clinical trials.

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Bronchial carcinoid tumors: nodal status and long-term survival after resection

Cited by 207 publications

References 20 publications

Survival and Predictors of Death for Patients with Bronchopulmonary Carcinoid at a Danish Tertiary NET Centre

Survival and Predictors of Death for Patients with Bronchopulmonary Carcinoid at a Danish Tertiary NET Centre

Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors

Prognostic factors influencing survival from metastatic (stage IV) gastroenteropancreatic well-differentiated endocrine carcinoma

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