Bromelain inhibits the inflammation and senescence effect in diabetic periodontitis: A preliminary in vitro study

Lu, Hung-Chieh; Ng, Min Yee; Liao, Yi-Wen; Maekawa, Shogo; Lin, Taichen; Yu, Cheng–Chia

doi:10.1016/j.jds.2022.09.018

Cited by 7 publications

(3 citation statements)

References 40 publications

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“…Previous studies showed that bromelain had anti-inflammatory and antioxidant properties, which might help reduce inflammation and oxidative stress in individuals with diabetes. [100][101][102] By reducing inflammation and oxidative stress, bromelain might improve insulin sensitivity and glucose metabolism in cells, leading to better glycemic control. Overall, while the exact mechanisms by which bromelain exerts its anti-diabetic effects are not fully understood, it is evident that bromelain has the potential to improve glucose metabolism, insulin sensitivity, and glycemic control in individuals with diabetes (Fig.…”

Section: Diabetesmentioning

confidence: 99%

Bromelain: a review of its mechanisms, pharmacological effects and potential applications

Kumar¹,

Mangla²,

Javed³

et al. 2023

Food Funct.

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Section: Diabetesmentioning

confidence: 99%

Bromelain: a review of its mechanisms, pharmacological effects and potential applications

Kumar¹,

Mangla²,

Javed³

et al. 2023

Food Funct.

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“…The association between periodontitis and metabolic syndrome, which closely relates to diabetes mellitus, insulin resistance, and central obesity, has been mentioned. 25 HCV infection seems to interact with lipid and glucose metabolism, 21 and abundant research proved its association with an elevated risk of diabetes mellitus, 26,27 which is a recognized risk factor for periodontitis. 28 As one important extrahepatic manifestation of HCV virus, 29 insulin resistance may account for these relationships, which was also observed to be associated with increased incidence of periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009−2014

Fang,

Liu,

Mao

et al. 2024

Journal of Medical Virology

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Periodontitis is a cumulative inflammatory disease associated with multiple health conditions and various systemic diseases. As a common disease, virus infection along with its consequences has become a serious health burden. The study aims to evaluate the relationship between common viruses including hepatitis virus, human immunodeficiency virus (HIV), herpes simplex virus (HSV), human papillomavirus (HPV), and periodontitis. The data from the US National Health and Nutrition Examination Survey (NHANES) 2009−2014 was adopted and screened through, including 10 714 participants. Generalized linear regression was conducted to verify the relationships between the virus infections and periodontitis. Moreover, we also performed analyses in age and gender subgroups. The results suggested that the infection of HCV, HSV‐1, and HSV‐2 was significantly associated with the prevalence of periodontitis (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.26−1.70; OR 1.09, 95% CI 1.05−1.13; OR 1.06, 95% CI 1.01 ‐ 1.11, respectively) and risk of developing moderate or severe periodontitis (OR 1.51, 95% CI 1.29−1.77; OR 1.08, 95% CI 1.04−1.12; OR 1.05, 95% CI 1.01−1.10, respectively) after adjusting all relevant co‐factors. Subgroup analyses revealed a steady association between periodontitis and hepatitis C virus (HCV) or HSV‐1 infection, while the relationship between HSV‐2 and HPV infection can also be found in some subgroups. The presence of HCV and HSV infection was found to be significantly associated with the prevalence of periodontitis, including moderate or severe cases. Moreover, the association of periodontitis and HPV infection can also be observed in people < 35 years.

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“…Periodontitis often arises due to the host's immune response to microbial triggers present in the dental plaque, while the accumulation of advanced glycation end product (AGE) levels in DM magnifies this host response [5]. AGEs are acknowledged for inducing inflammaging, a state constituted by low-grade chronic inflammation and pre-aging in various periodontal tissues including human gingival fibroblast, keratinocytes, and macrophages [6][7][8][9][10]. Inflammaging was believed to accelerate the progression of DP through several mechanisms, including cellular senescence and senescence-associated secretory phenotype (SASP) [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Er:YAG Laser Alleviates Inflammaging in Diabetes-Associated Periodontitis via Activation CTBP1-AS2/miR-155/SIRT1 Axis

Ng,

Yu,

Chen

et al. 2024

IJMS

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Periodontitis is a significant health concern for individuals with diabetes mellitus (DM), characterized by inflammation and periodontium loss. Hyperglycaemia in DM exacerbates susceptibility to periodontitis by inducing inflammaging in the host immune system. The use of erbium-doped yttrium–aluminum–garnet laser (ErL) in periodontitis treatment has gained attention, but its impact on diabetic-associated periodontitis (DP) and underlying mechanisms remain unclear. In this study, we simulated DP by exposing human periodontal ligament fibroblasts (PDLFs) to advanced glycation end products (AGEs) and lipopolysaccharides from P. gingivalis (Pg-LPS). Subsequently, we evaluated the impact of ErL on the cells’ wound healing and assessed their inflammaging markers. ErL treatment promoted wound healing and suppressed inflammaging activities, including cell senescence, IL-6 secretion, and p65 phosphorylation. Moreover, the laser-targeted cells were observed to have upregulated expression of CTBP1-AS2, which, when overexpressed, enhanced wound healing ability and repressed inflammaging. Moreover, bioinformatic analysis revealed that CTBP1-AS2 acted as a sponge for miR155 and upregulated SIRT1. In conclusion, ErL demonstrated the ability to improve wound healing and mitigate inflammaging in diabetic periodontal tissue through the CTBP1-AS2/miR-155/SIRT1 axis. Targeting this axis could represent a promising therapeutic approach for preventing periodontitis in individuals with DM.

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Bromelain inhibits the inflammation and senescence effect in diabetic periodontitis: A preliminary in vitro study

Cited by 7 publications

References 40 publications

Bromelain: a review of its mechanisms, pharmacological effects and potential applications

Bromelain: a review of its mechanisms, pharmacological effects and potential applications

Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009−2014

Er:YAG Laser Alleviates Inflammaging in Diabetes-Associated Periodontitis via Activation CTBP1-AS2/miR-155/SIRT1 Axis

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