Bromelain: a review of its mechanisms, pharmacological effects and potential applications

Kumar, Virender; Mangla, Bharti; Javed, Shamama; Ahsan, Waquar; Kumar, Pankaj; Sangwan, Vandana; Dureja, Harish

doi:10.1039/d3fo01060k

Cited by 7 publications

(2 citation statements)

References 156 publications

(235 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most commonly reported side effects in the literature were stomach upset and diarrhea, increased heart rate, hives and throat tightness even if for very high doses and, in any case, not frequently [21]. In the present study, no side effects were reported in short-term and distant controls.…”

Section: Discussionsupporting

confidence: 51%

Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients

Consorti,

Monarchi,

Paglianiti

et al. 2024

JCM

View full text Add to dashboard Cite

Background: Bromelain and coumarins are recognized as safe and effective therapeutic agents, used by individuals to treat ailments such as postoperative edema, inflammation and other diseases. Bromelain has been proven to be well absorbed by the body after oral administration, and it has no major side effects even after prolonged use. The purpose of this study is to evaluate the effectiveness of bromelain and other nutraceuticals in reducing post-surgical swelling, pain and the need of anti-inflammatory drugs in maxillofacial post-traumatic surgery. Methods: This prospective open-label study was conducted on patients undergoing surgery for trauma of the maxillofacial area. One hundred patients were selected and divided into two groups: one group who underwent therapy with bromelain, Aesculus hippocastanum and Melilotus officinalis and a control group that was not given the drug in postoperative therapy. Results: Patients in the experimental group showed a reduction of edema in the first and second postoperative weeks, a faster complete reduction of facial edema and a lower reduction in maximum mouth opening and needed less anti-inflammatory therapy to control pain. Conclusions: These findings seem to provide evidence that Brovas® may be effective in improving postoperative edema outcomes in patients undergoing surgical treatment of facial fractures.

show abstract

Section: Discussionsupporting

confidence: 51%

Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients

Consorti,

Monarchi,

Paglianiti

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…Since its discovery, numerous in vitro and in vivo studies have shown that bromelain has various phytomedical activities: anti-inflammatory, fibrinolytic, anti-coagulative, antithrombotic, drug absorption-enhancing, and, most interestingly, anticancer actions [ 81 , 83 , 85 , 89 ]. Even though the anticancer effect is mainly due to enzymatic activity, some studies have highlighted that the non-enzymatic components of bromelain (polysaccharides, glycoproteins, vitamin C, β-carotene, and flavonoids) have a synergistic impact on the complex network involved [ 82 , 90 ]. Numerous studies have shown that, depending on the milieu, bromelain modulates the immune response in different ways.…”

Section: Bromelainmentioning

confidence: 99%

Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies

Mecca,

Sichetti,

Giuseffi

et al. 2024

Nutrients

View full text Add to dashboard Cite

Breast cancer is the most common tumor in women. Chemotherapy is the gold standard for cancer treatment; however, severe side effects and tumor resistance are the major obstacles to chemotherapy success. Numerous dietary components and phytochemicals have been found to inhibit the molecular and signaling pathways associated with different stages of breast cancer development. In particular, this review is focused on the antitumor effects of PUFAs, dietary enzymes, and glucosinolates against breast cancer. The major databases were consulted to search in vitro and preclinical studies; only those with solid scientific evidence and reporting protective effects on breast cancer treatment were included. A consistent number of studies highlighted that dietary components and phytochemicals can have remarkable therapeutic effects as single agents or in combination with other anticancer agents, administered at different concentrations and via different routes of administration. These provide a natural strategy for chemoprevention, reduce the risk of breast cancer recurrence, impair cell proliferation and viability, and induce apoptosis. Some of these bioactive compounds of dietary origin, however, show poor solubility and low bioavailability; hence, encapsulation in nanoformulations are promising tools able to increase clinical efficiency.

show abstract

Nutritional Composition and Therapeutic Potential of Pineapple Peel – A Comprehensive Review

Mehraj,

Das,

Feroz

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Pineapple (Ananas comosus), the succulent and vibrant tropical fruit, is a symbol of exoticism and sweetness. The pineapple peel, often considered as waste, has garnered attention for its potential applications. The pineapple peel is rich in essential nutrients, including calcium, potassium, vitamin C, carbohydrates, dietary fiber, and water, making it beneficial for the digestive system, weight management, and overall balanced nutrition. It contains significant amounts of sugars such as sucrose, glucose, and fructose, along with citric acid as the predominant organic acid. The peel also contains bromelain, a proteolytic enzyme known for its digestive properties. Studies have highlighted the pharmacological properties of pineapple peel, such as its potential anti‐parasitic effects, alleviation of constipation, and benefits for individuals with irritable bowel syndrome (IBS). Efforts are being made to promote the utilization of pineapple peel as a valuable resource rather than mere waste. Its applications range from the production of vinegar, alcohol, and citric acid to the development of various food products, including squash, syrup, jelly, and pickles. Further research and innovation are required to fully explore the potential of pineapple peel and establish sustainable practices for its utilization, contributing to waste reduction and the development of value‐added products.

show abstract

Bromelain: a review of its mechanisms, pharmacological effects and potential applications

Abstract: The utilization of plant-derived supplements for disease prevention and treatment has long been recognized for their remarkable potential. Ananas comosus, commonly known as pineapple, produces a group of enzymes called...

Cited by 7 publications

References 156 publications

Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients

Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients

Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies

Nutritional Composition and Therapeutic Potential of Pineapple Peel – A Comprehensive Review

Contact Info

Product

Resources

About