Broadly tunable ultraviolet miniature cerium-doped LiLuF lasers

Liu, H.; Spence, David J.; Coutts, David W.; Sato, Hiroki; Fukuda, Tsuguo

doi:10.1364/oe.16.002226

Opt. Express

2008

DOI: 10.1364/oe.16.002226

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Broadly tunable ultraviolet miniature cerium-doped LiLuF lasers

H. Liu¹,

David J. Spence²,

David W. Coutts³

et al.

Abstract: Ultraviolet (UV) miniature cerium fluoride lasers have been demonstrated using a low cost, frequency-quadrupled microchip Nd:YAG pump laser. The use of miniature laser cavities was shown to significantly improve the laser performance in the low pump power region. We have achieved slope efficiencies up to 70% and pump thresholds as low as 100 nJ. Continuous tuning from 306 nm to 338 nm was achieved using a Brewster angle prism.

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Cited by 8 publications

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“…A frequency-quadrupled Nd:YVO 4 (and Nd:YAG) laser at 266 nm can excite most lanthanide; however, such a deep UV is too destructive to the biology system and requires the optics to function at that short wavelength. Although recent solid-state laser research has demonstrated pulsed laser sources for this wavelength band (27,28), they are far more expensive compared with the light emitting diode (LED) sources (10,29). Another problem arising from this bandwidth is that the routine microscopes have too low transmission to deliver the power to the specimen, since most microscopy objectives and slide cover slips have the cuton edge from 330 to 340 nm.…”

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Demonstration of true‐color high‐contrast microorganism imaging for terbium bioprobes

Jin

2011

Cytometry Pt A

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Lanthanide bioprobes offer a number of novel advantages for advanced cytometry, including the microsecond luminescence lifetime, sharp spectral emission, and large stokes shift. However, to date, only the europium-based bioprobes have been broadly studied for time-gated luminescence cell imaging, though a wide range of efficient terbium bioprobes have been synthesized and some of them are commercially available. We analyze that the bottleneck problem was due to the lack of an efficient microscope with pulsed excitation at wavelengths of 300-330 nm. We investigate a recently available 315 nm ultraviolet (UV) light emitting diode to excite an epifluorescence microscope. Substituting a commercial UV objective (403), the 315 nm light efficiently delivered the excitation light onto the uncovered specimen. A novel pinhole-assisted optical chopper unit was attached behind the eyepiece for direct lifetime-gating to permit visual inspection of background-free images. We demonstrate the use of a commercial terbium complex for high-contrast imaging of an environmental pathogenic microorganism, Cryptosporidium parvum. As a result of effective autofluorescence suppression by a factor of 61.85 in the time domain, we achieved an enhanced signal-to-background ratio of 14.43. This type of time-gating optics is easily adaptable to the use of routine epifluorescence microscopes, which provides an opportunity for high-contrast imaging using multiplexed lanthanide bioprobes. ' International Society for Advancement of CytometryKey terms time-gated luminescence; bioimaging; terbium; UV LED; Cryptosporidium; high-contrast EPIFLUORESCENCE microscopes are routinely found in both research and diagnostic laboratories. From the practical point of view, cytometrists expect a microscope to be low cost, compact, easy-to-operate at high sensitivity, including the capacity to discriminate against nontarget substance, detect multiple species at once, and have high throughput. Time-domain discrimination of targeted microorganisms using long-lifetime lanthanide bioprobes shows promise in meeting these demands. This is due to the ease of time-gating of probes that have lifetimes of several hundreds of microseconds, which eliminates the autofluorescent background of several nanoseconds (1). In practice, however, there are several bottleneck problems challenging both the instrumentation and bioprobe developments. To date, only the europiumbased bioprobes (excited at 330-420 nm, emitting 615 nm at $10 nm bandwidth) have been broadly studied for time-gated luminescence cell imaging (1-15). This is due to the fact that other rare-earth ion complexes are either less efficient (16) [only europium and terbium complexes are less sensitive to vibrational quenching by energy transfer to OH, NH, or CH oscillators (15)] or require pulsed ultraviolet (UV) excitation below 330 nm (17). Another reason is the lack of near-infrared detection cameras. In fact, some cameras have included near-infrared blocking filters. For example, many efficient terbium-base...

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confidence: 99%

Demonstration of true‐color high‐contrast microorganism imaging for terbium bioprobes

Jin

2011

Cytometry Pt A

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Yb-fiber-laser-pumped, high-repetition-rate picosecond optical parametric oscillator tunable in the ultraviolet

Samanta¹,

Kumar²,

Aadhi³

et al. 2014

Opt. Express

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We report a compact tunable 240-MHz picosecond source for the ultraviolet based on intra-cavity frequency doubling of a signal-resonant MgO:sPPLT optical parametric oscillator (OPO), synchronously pumped at 532 nm in the green by the second harmonic of a mode-locked Yb-fiber laser at 80-MHz repetition rate. By deploying a 30-mm-long multi-grating MgO:sPPLT crystal for the OPO and a 5-mm-long BiB(3)O(6) crystal for internal doubling, we have generated tunable UV radiation across 317-340.5 nm, with up to 30 mW at 334.5 nm. The OPO also provides tunable visible signal in the red, across 634-681 nm, and mid-infrared idler radiation over 2429-3298 nm, with as maximum signal power of 800 mW at 642 nm. The signal pulses have a temporal duration of 12 ps at 665 nm and exhibit high spatial beam quality with Gaussian profile. The signal power is recorded to be naturally stable with a fluctuation of 1.4% rms over 14 hours, while UV power degradation has been observed and studied.

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Extended femtosecond laser wavelength range to 330 nm in a high power LBO based optical parametric oscillator

Fan¹,

Gu²,

Wang³

et al. 2016

Opt. Express

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We experimentally demonstrate a compact tunable, high average power femtosecond laser source in the ultraviolet (UV) regime. The laser source is based on intra-cavity frequency doubling of a temperature-tuned lithium tribotate (LBO) optical parametric oscillator (OPO), synchronously pumped at 520 nm by a frequency-doubled, Yb-fiber femtosecond laser amplifier system. By adjusting crystal temperature, the OPO can provide tunable visible to near-infrared (NIR) signal pulse, which have a wide spectral tuning range from 660 to 884 nm. Using a β-barium borate (BBO) crystal for intra-cavity frequency doubling, tunable femtosecond UV pulse are generated across 330~442 nm with up to 364 mW at 402 nm.

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Broadly tunable ultraviolet miniature cerium-doped LiLuF lasers

Cited by 8 publications

References 10 publications

Demonstration of true‐color high‐contrast microorganism imaging for terbium bioprobes

Demonstration of true‐color high‐contrast microorganism imaging for terbium bioprobes

Yb-fiber-laser-pumped, high-repetition-rate picosecond optical parametric oscillator tunable in the ultraviolet

Extended femtosecond laser wavelength range to 330 nm in a high power LBO based optical parametric oscillator

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