Broad‐Spectrum Antiviral Peptides and Polymers

Kuroki, Agnès; Tay, Joyce; Lee, Guan Huei; Yang, Yi Yan

doi:10.1002/adhm.202101113

Cited by 25 publications

(25 citation statements)

References 216 publications

(279 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So, polymers func-tionalized with the guanidine moiety show a broad spectrum of antiviral activity against Equine herpes virus type 1, Rhinotracheitis infectious bovine and Equine infectious anemia virus. 171 Such polymers showed antiviral properties only when administered prior to infection, thus suggesting that the mode of action of these polymers was again inhibition of viral attachment to the host cells by itself binding to the phospholipids of the host cell membrane. 171…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial mechanisms of biomaterials: from macro to nano

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Biomaterials Science Reviewmentioning

confidence: 99%

“…171 Such polymers showed antiviral properties only when administered prior to infection, thus suggesting that the mode of action of these polymers was again inhibition of viral attachment to the host cells by itself binding to the phospholipids of the host cell membrane. 171…”

Section: Antimicrobial Mechanisms Of Macroscale Biomaterialsmentioning

confidence: 99%

Antimicrobial mechanisms of biomaterials: from macro to nano

et al. 2022

View full text Add to dashboard Cite

show abstract

“…While here the focus is exclusively on sGAG mimetic polymeric compounds, there are also other classes of polymers with antiviral activity, and we direct the readers to recent reviews on the topic. 156 , 157 …”

Section: Hs Mimetics As Viral Inhibitorsmentioning

confidence: 99%

Polymers Inspired by Heparin and Heparan Sulfate for Viral Targeting

2022

View full text Add to dashboard Cite

Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-known for their diverse biological activities. While HP is generally localized in mast cells and in connective tissues, HS is part of the glycocalyx and involved in the attachment of viruses to host cells, constituting the first step of an infection. HP and HS also exhibit antiviral activity by blocking viral receptors, thereby inhibiting viruses from engaging with host cells. Inspired by their structural features, such as their high molecular weight and polyanionic character, various synthetic polymers mimicking HP/HS have been developed and used as model systems to study bioactivity, as well as for therapeutic applications. This Perspective provides an overview of the roles of HP/HS in viral engagement, and examines historical and recent approaches toward oligo-/polysaccharide, glycopolymer, and anionic polymer HP/HS mimetics. An overview of current applications and future prospects of these molecules is provided, demonstrating their potential in addressing current and future epidemics and pandemics.

show abstract

“…Because of its broad-spectrum mechanism and huge potential sequence diversity, peptides that inhibit viral entry may potentially meet the demand for new antiviral therapy; however, to optimize or evolve sequence design to combat a wide range of viral diseases, their mechanisms need to be better understood ( 28 ). Notably, the low yields and difficulties in the extraction and purification of AMPs have hindered their industry and scientific research applications.…”

Section: Introductionmentioning

confidence: 99%

Bomidin: An Optimized Antimicrobial Peptide With Broad Antiviral Activity Against Enveloped Viruses

Liu

Peng

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

The rapid evolution of highly infectious pathogens is a major threat to global public health. In the front line of defense against bacteria, fungi, and viruses, antimicrobial peptides (AMPs) are naturally produced by all living organisms and offer new possibilities for next-generation antibiotic development. However, the low yields and difficulties in the extraction and purification of AMPs have hindered their industry and scientific research applications. To overcome these barriers, we enabled high expression of bomidin, a commercial recombinant AMP based upon bovine myeloid antimicrobial peptide-27. This novel AMP, which can be expressed in Escherichia coli by adding methionine to the bomidin sequence, can be produced in bulk and is more biologically active than chemically synthesized AMPs. We verified the function of bomidin against a variety of bacteria and enveloped viruses, including severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), herpes simplex virus (HSV), dengue virus (DENV), and chikungunya virus (CHIKV). Furthermore, based on the molecular modeling of bomidin and membrane lipids, we elucidated the possible mechanism by which bomidin disrupts bacterial and viral membranes. Thus, we obtained a novel AMP with an optimized, efficient heterologous expression system for potential therapeutic application against a wide range of life-threatening pathogens.

show abstract

Broad‐Spectrum Antiviral Peptides and Polymers

Cited by 25 publications

References 216 publications

Antimicrobial mechanisms of biomaterials: from macro to nano

Antimicrobial mechanisms of biomaterials: from macro to nano

Polymers Inspired by Heparin and Heparan Sulfate for Viral Targeting

Bomidin: An Optimized Antimicrobial Peptide With Broad Antiviral Activity Against Enveloped Viruses

Contact Info

Product

Resources

About