Bringing hydrogel-based craniofacial therapies to the clinic

Trubelja, Alen; Kasper, F. Kurtis; Farach‐Carson, Mary C.; Harrington, Daniel A.

doi:10.1016/j.actbio.2021.10.056

Cited by 8 publications

(7 citation statements)

References 178 publications

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“…Hydrogels can be classified based on different parameters, including the source of materials (natural or synthetic), polymeric composition (homopolymeric, copolymeric, or multipolymeric), crosslinking mechanism (physical or chemical), sample size (nanogels, microgels, macrogels, or bulk hydrogels), and degradability (degradable or nondegradable) [ 47 , 48 , 49 , 50 ]. Considering the numerous excellent review articles on the introduction, classification, preparation, and application of hydrogels that have already been published [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ], we will refrain from providing an exhaustive classification of hydrogels in this work.…”

Section: Hydrogelsmentioning

confidence: 99%

Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment

Gan

Zhang

et al. 2023

Gels

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Phototherapeutic agent-based phototherapies activated by light have proven to be safe modalities for the treatment of various malignant tumor indications. The two main modalities of phototherapies include photothermal therapy, which causes localized thermal damage to target lesions, and photodynamic therapy, which causes localized chemical damage by generated reactive oxygen species (ROS). Conventional phototherapies suffer a major shortcoming in their clinical application due to their phototoxicity, which primarily arises from the uncontrolled distribution of phototherapeutic agents in vivo. For successful antitumor phototherapy, it is essential to ensure the generation of heat or ROS specifically occurs at the tumor site. To minimize the reverse side effects of phototherapy while improving its therapeutic performance, extensive research has focused on developing hydrogel-based phototherapy for tumor treatment. The utilization of hydrogels as drug carriers allows for the sustained delivery of phototherapeutic agents to tumor sites, thereby limiting their adverse effects. Herein, we summarize the recent advancements in the design of hydrogels for antitumor phototherapy, offer a comprehensive overview of the latest advances in hydrogel-based phototherapy and its combination with other therapeutic modalities for tumor treatment, and discuss the current clinical status of hydrogel-based antitumor phototherapy.

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Section: Hydrogelsmentioning

confidence: 99%

Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment

Gan

Zhang

et al. 2023

Gels

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“…To date, bioprinted structures have only been transplanted into a small number of patients and, at the time of writing, there is only one active clinical trial examining the safety and efficacy of a 3DBP graft [1, 183]. In order to meet the growing demand for novel joint regeneration methods, key players in research and development must frequently interface with regulators to close policy gaps before large‐scale trials can proceed in humans.…”

Section: Overall Conclusionmentioning

confidence: 99%

Systematic review on the application of 3D-bioprinting technology in orthoregeneration: current achievements and open challenges

et al. 2022

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Background Joint degeneration and large or complex bone defects are a significant source of morbidity and diminished quality of life worldwide. There is an unmet need for a functional implant with near-native biomechanical properties. The potential for their generation using 3D bioprinting (3DBP)-based tissue engineering methods was assessed. We systematically reviewed the current state of 3DBP in orthoregeneration. Methods This review was performed using PubMed and Web of Science. Primary research articles reporting 3DBP of cartilage, bone, vasculature, and their osteochondral and vascular bone composites were considered. Full text English articles were analyzed. Results Over 1300 studies were retrieved, after removing duplicates, 1046 studies remained. After inclusion and exclusion criteria were applied, 114 articles were analyzed fully. Bioink material types and combinations were tallied. Cell types and testing methods were also analyzed. Nearly all papers determined the effect of 3DBP on cell survival. Bioink material physical characterization using gelation and rheology, and construct biomechanics were performed. In vitro testing methods assessed biochemistry, markers of extracellular matrix production and/or cell differentiation into respective lineages. In vivo proof-of-concept studies included full-thickness bone and joint defects as well as subcutaneous implantation in rodents followed by histological and µCT analyses to demonstrate implant growth and integration into surrounding native tissues. Conclusions Despite its relative infancy, 3DBP is making an impact in joint and bone engineering. Several groups have demonstrated preclinical efficacy of mechanically robust constructs which integrate into articular joint defects in small animals. However, notable obstacles remain. Notably, researchers encountered pitfalls in scaling up constructs and establishing implant function and viability in long term animal models. Further, to translate from the laboratory to the clinic, standardized quality control metrics such as construct stiffness and graft integration metrics should be established with investigator consensus. While there is much work to be done, 3DBP implants have great potential to treat degenerative joint diseases and provide benefit to patients globally.

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“…Hydrogels are soft-solid materials with a cross-linked three-dimensional polymer network. Owing to their high hydrophilic properties and unique structures, hydrogels have been widely applied in drug delivery, wound healing, tissue engineering scaffolds, and cosmetics. − Injectable hydrogels with superior functional properties are promising biomaterials for soft tissue augmentation due to their simple application procedures and low costs. , Under shear stress, the viscosity of hydrogels decreases significantly, enabling the injectability as a liquid. Subsequently, injectable hydrogels recover their original network structure and mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel Based on Riclin Cross-Linked with Polyethylene Glycol Diglycidyl Ether as a Soft Filler for Tissue Engineering

Lu,

Wang,

Kong

et al. 2024

Biomacromolecules

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Hydrogels composed of natural polysaccharides have been widely used as filling materials, with a growing interest in medical cosmetology and skin care. However, conventional commercial dermal fillers still have limitations, particularly in terms of mechanical performance and durability in vivo. In this study, a novel injectable and implantable hydrogel with adjustable characteristics was prepared from succinoglycan riclin by introducing PEG diglycidyl ether as a cross-linker. FTIR spectra confirmed the cross-linking reaction. The riclin hydrogels exhibited shear-thinning behavior, excellent mechanical properties, and cytocompatibility through in vitro experiments. Furthermore, when compared with subcutaneous injection of a commercial hyaluronic acid hydrogel, the riclin hydrogels showed enhanced persistence and biocompatibility in Balb/c mice after 16 weeks. These results demonstrate the great potential of the riclin-based hydrogel as an alternative to conventional commercial soft tissue fillers.

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Bringing hydrogel-based craniofacial therapies to the clinic

Cited by 8 publications

References 178 publications

Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment

Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment

Systematic review on the application of 3D-bioprinting technology in orthoregeneration: current achievements and open challenges

Hydrogel Based on Riclin Cross-Linked with Polyethylene Glycol Diglycidyl Ether as a Soft Filler for Tissue Engineering

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