“…(This lack of change may reflect the utilization of symptom measures such as the Autism Diagnostic Observation Schedule, which, as a diagnostic tool, was designed to be relatively stable; measures specifically designed and validated as being sensitive to change are needed.) Specifically, targeted interventions have been associated with gains in imitation, 16,19 joint attention, 16,20,32,34 social engagement, 20,32,33 other social communication measures, 34 and functional and symbolic play. 20,32 Impaired effortful control (ie, a reduced ability to regulate attention, emotions, and behavior to achieve goals) has been reported in children with ASD as early as at 24 months of age.…”