Brief Report: Exploratory Analysis of the ADOS Revised Algorithm: Specificity and Predictive Value with Hispanic Children Referred for Autism Spectrum Disorders

Abstract

This study compared Autism diagnostic observation schedule (ADOS) algorithm scores of a sample of 26 children who were administered modules 1-3 of the ADOS with the scores obtained applying the revised ADOS algorithm proposed by Gotham et al. (2007). Results of this application were inconsistent, yielding slightly more accurate results for module 1. New algorithm scores on modules 2 and 3 remained consistent with the original algorithm scores. The Mann-Whitney U was applied to compare revised algorithm and clinical levels of social impairment to determine if significant differences were evident. Results of Mann-Whitney U analyses were inconsistent and demonstrated less specificity for children with milder levels of social impairment. The revised algorithm demonstrated accuracy for the more severe autistic group.

Identification of Males with Cryptic Fragile X Alleles by Methylation-Specific Quantitative Melt Analysis

“…Clinical assessments included an intelligence quotient test performed with the Wechsler Intelligence Scale for Children (WISC-III) and Wechsler Adult Intelligence Scale (WAIS-IV) (32,33 ). The presence of autism spectrum disorder was determined with the Autism Observation Scale (ADOS) (34 ).…”

Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children

“…They now provide valuable information for clinicians in order to establish an early diagnosis (Charman and Gotham 2013). For the ADOS-2, the revised algorithms for modules 1 and 2 and the algorithms for the Toddler module have shown significant value in the early diagnosis of ASD (Gotham et al 2007, 2008; Luyster et al 2009; Molloy et al 2011; Oosterling et al 2010b, Overton et al 2008). …”

How useful are screening instruments for toddlers to predict outcome at age 4? General development, language skills, and symptom severity in children with a false positive screen for autism spectrum disorder

“…A classification of autism or ASD is given if the child has scores higher than established cut-off values. A new scoring algorithm was developed by Gotham and colleagues [26] to improve the discriminant ability of the ADOS, which was replicated by several other studies [30][31][32][33][34]. This revised algorithm also includes items related to repetitive behaviours and restricted interests next to items regarding social affect.…”