Brief psychoeducation for bipolar disorder: Evaluation of trophic factors serum levels in young adults

Wiener, Carolina David; Molina, Mariane Lopez; Moreira, Fernanda Pedrotti; Passos, Miguel Bezerra dos; Jansen, Karen; Silva, Ricardo Azevedo da; Souza, Luciano Dias de Mattos; Oses, Jean Pierre

doi:10.1016/j.psychres.2017.07.062

Cited by 13 publications

(11 citation statements)

References 40 publications

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“…Some findings suggest that neurotrophins appear to be decreased in individuals with BD . Thus, the present study also investigated the role of neurotrophins, BDNF, GDNF, and NGF in the diagnostic conversion.…”

Section: Discussionmentioning

confidence: 95%

Serum level of nerve growth factor is a potential biomarker of conversion to bipolar disorder in women with major depressive disorder

Moreira

Cardoso

Mondin

et al. 2019

Psychiatry Clin Neurosci

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Aim The aim of this study was to identify biomarkers associated with major depressive disorder (MDD) and conversion from MDD to bipolar disorder (BD) in an outpatient sample of women. Methods This was a longitudinal study including women diagnosed with MDD and aged 18 to 60 years. The follow‐up was 3 years. The diagnosis was performed using the Mini International Neuropsychiatric Interview Plus. Blood collection was just performed in the first phase. Serum interleukin‐6, tumor necrosis factor‐α, brain‐derived neurotrophic factor, glial cell‐derived neurotrophic factor, and nerve growth factor (NGF) levels were measured using a commercial immunoassay kit. Results We included 156 women. The conversion rate from MDD to BD was 15.4% (n = 24). NGF serum levels were increased in patients who converted to BD compared to the remitted MDD group and current MDD group (P = 0.013). The Bonferroni post‐hoc test for multiple comparisons revealed significant differences for higher NGF levels in patients who converted to BD compared to patients with current MDD (P = 0.037). Interleukin‐6, tumor necrosis factor‐α, brain‐derived neurotrophic factor, and glial cell‐derived neurotrophic factor serum levels did not differ among the groups. Conclusion Our results suggest that NGF might be a useful biomarker associated with early detection of conversion to BD, helping clinicians in the clinical diagnosis.

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Section: Discussionmentioning

confidence: 95%

Serum level of nerve growth factor is a potential biomarker of conversion to bipolar disorder in women with major depressive disorder

Moreira

Cardoso

Mondin

et al. 2019

Psychiatry Clin Neurosci

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“…Two studies included patients with depressed mood[ 31 , 32 ]. Sixteen publications did not evaluate the mood episodes of the patients[ 12 - 15 , 22 - 24 , 27 , 29 , 30 , 34 , 36 , 38 - 40 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

“…The DSM-IV diagnostic criteria for BD were applied in twenty-nine studies[ 6 , 8 , 11 , 12 , 15 , 16 , 18 - 21 , 23 - 26 , 29 - 35 , 37 , 40 , 42 , 43 , 46 , 47 ]. The DSM-III was applied in four studies[ 13 , 27 , 39 , 44 ], and the ICD-10 criteria were applied in two studies[ 22 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

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Psychoeducation in bipolar disorder: A systematic review

Rabelo¹,

Cruz²,

Ferreira³

et al. 2021

WJP

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BACKGROUND Bipolar disorder (BD) is a severe psychiatric disorder characterized by mood swings. Psychosocial interventions, such as psychoeducation, play an essential role in promoting social rehabilitation and improving pharmacological treatment. AIM To investigate the role of psychoeducation in BD. METHODS A systematic review of original studies regarding psychoeducation interventions in patients with BD and their relatives was developed. A systematic literature search was performed using the Medline, Scopus, and Lilacs databases. No review articles or qualitative studies were included in the analysis. There were no date restriction criteria, and studies published up to April 2021 were included. RESULTS A total of forty-seven studies were selected for this review. Thirty-eight studies included patients, and nine included family members. Psychoeducation of patients and family members was associated with a lower number of new mood episodes and a reduction in number and length of stay of hospitalizations. Psychoeducational interventions with patients are associated with improved adherence to drug treatment. The strategies studied in patients and family members do not interfere with the severity of symptoms of mania or depression or with the patient's quality of life or functionality. Psychoeducational interventions with family members do not alter patients' adherence to pharmacotherapy. CONCLUSION Psychoeducation as an adjunct strategy to pharmacotherapy in the treatment of BD leads to a reduction in the frequency of new mood episodes, length of hospital stay and adherence to drug therapy.

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“…In this line, some authors have proposed brief psychoeducation interventions, ranging from four sessions [ 16 , 17 ] to eight sessions [ 18 , 19 ]. These latter interventions have been shown to improve bipolar symptomatology [ 18 , 20 ], internalized stigmatization [ 21 ], knowledge of the disorder [ 22 ], relapse rates [ 18 , 19 ], quality of life [ 19 ], psychosocial functioning [ 17 , 18 ], and medication adherence [ 23 ]. However, there are few studies [ 18 , 19 ] evaluating their effect using more pragmatic variables, such as the number of hospitalizations or time to recurrence, which provide objective measures of effectiveness.…”

Section: Introductionmentioning

confidence: 99%

A Real-World Study of the Association between a Brief Group Psychoeducation and the Course of Bipolar Disorder

Casellas

Raventós

Piñeiro-Ríos

et al. 2021

IJERPH

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Although pharmacotherapy is considered the first-line treatment for bipolar disorders (BD), adjunctive psychoeducation has proven its effectiveness in improving self-management of the disease and reducing relapse rates. Few studies have evaluated the effect of brief group psychoeducation on pragmatic variables, such as the number of hospitalizations. The aim of the present study was to assess the mid-term effect of a four-session group psychoeducation on course-related variables in BD. Thirty-two individuals with BD were included in the study. Sixteen were exposed to psychoeducation and were matched to sixteen nonexposed individuals who received their usual treatment. Both groups were compared on insight, treatment adherence, change in the number of hospitalizations and visits to the emergency services, occurrence rate after intervention, and time to the first psychiatric hospitalization and the first urgent attendance. There was a significant reduction in the mean number of hospitalizations and urgent attendances in the exposed group in comparison to the nonexposed group. The first urgent attendance was significantly sooner in the nonexposed cohort. There were no differences between groups in any of the other variables. This intervention has shown benefits for pragmatic variables of the disease course and may be a feasible and cost-effective intervention to routinely implement in the management of BD.

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Brief psychoeducation for bipolar disorder: Evaluation of trophic factors serum levels in young adults

Cited by 13 publications

References 40 publications

Serum level of nerve growth factor is a potential biomarker of conversion to bipolar disorder in women with major depressive disorder

Serum level of nerve growth factor is a potential biomarker of conversion to bipolar disorder in women with major depressive disorder

Psychoeducation in bipolar disorder: A systematic review

A Real-World Study of the Association between a Brief Group Psychoeducation and the Course of Bipolar Disorder

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