Brief, high intensity exercise alters serum ghrelin and growth hormone concentrations but not IGF-I, IGF-II or IGF-I bioactivity

Stokes, Keith; Sykes, Dave; Gilbert, Kate L.; Chen, Jianwen; Frystyk, Jan

doi:10.1016/j.ghir.2010.03.004

Cited by 25 publications

(21 citation statements)

References 45 publications

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“…Total GH AUC and peak GH concentration during the SLEEP condition were similar to previously reported research (Stokes et al. ,b, , , , ; Stokes ) but during the SLD session they were increased 2.7‐fold and 2.2‐fold, respectively. Our subjects were not sprint‐trained and had exercise‐induced peak GH concentrations during SLEEP that were similar to endurance trained males during a 30‐sec treadmill sprint (17.8 vs. 15.9 μ g/L, respectively).…”

Section: Discussionsupporting

confidence: 89%

Exercise-Induced growth hormone during acute sleep deprivation

2014

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The effect of acute (24‐h) sleep deprivation on exercise‐induced growth hormone (GH) and insulin‐like growth factor‐1 (IGF‐1) was examined. Ten men (20.6 ± 1.4 years) completed two randomized 24‐h sessions including a brief, high‐intensity exercise bout following either a night of sleep (SLEEP) or (24‐h) sleep deprivation (SLD). Anaerobic performance (mean power [MP], peak power [PP], minimum power [MinP], time to peak power [TTPP], fatigue index, [FI]) and total work per sprint [TWPS]) was determined from four maximal 30‐sec Wingate sprints on a cycle ergometer. Self‐reported sleep 7 days prior to each session was similar between SLEEP and SLD sessions (7.92 ± 0.33 vs. 7.98 ± 0.39 h, P =0.656, respectively) and during the actual SLEEP session in the lab, the total amount of sleep was similar to the 7 days leading up to the lab session (7.72 ± 0.14 h vs. 7.92 ± 0.33 h, respectively) (P =0.166). No differences existed in MP, PP, MinP, TTPP, FI, TWPS, resting GH concentrations, time to reach exercise‐induced peak GH concentration (TTP), or free IGF‐1 between sessions. GH area under the curve (AUC) (825.0 ± 199.8 vs. 2212.9 ± 441.9 μg/L*min, P <0.01), exercise‐induced peak GH concentration (17.8 ± 3.7 vs. 39.6 ± 7.1 μg/L, P <0.01) and ΔGH (peak GH – resting GH) (17.2 ± 3.7 vs. 38.2 ± 7.3 μg/L, P <0.01) were significantly lower during the SLEEP versus SLD session. Our results indicate that the exercise‐induced GH response was significantly augmented in sleep‐deprived individuals.

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Section: Discussionsupporting

confidence: 89%

Exercise-Induced growth hormone during acute sleep deprivation

2014

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“…Unfortunately, to our knowledge and research on different data base, we think there is no published data in relation to pistachio-atlantica aqueous extraction combined with treadmill running program on liver ghrline mRNA expression. However, our present study data are partially consistent to those results previously reported by the several investigators [8,[73][74][75][76][77][78][79]. A lower liver ghrelin RNA expression in trained rats regardless of the solutions treatment, might be attributed to lower plasma estradiol concentrations [80,81].…”

Section: Figure 8 Plasma Estradiol Level In Different Groupssupporting

confidence: 93%

Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression

Shirvani¹,

Ghanbari–Niaki²,

Rahmati-Ahmadabad

et al. 2017

Int J Appl Exerc Physiol

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ABSTRACT:The aim of present study was to investigate the effects of aerobic training with and without Pistacia-atlantica (Bane) extraction as a plant rich in fatty acids, on rat tissues nesfatin-1/nucleobindin-2 and ghrelin gene expression and also on plasma lipid and lipoproteins profiles.Twenty healthy and intact Wistar rats were obtain and randomly were assigned into saline-control (SC), saline-training (ST), Bane-control (BC), and Bane-training (BT) groups. Training groups ran on a motor driven treadmill (at intensity 25m/min, 5days/wk.) for 8 weeks. Rats were orally received saline or bene solution (100 mg/kg and 7.5ul/g of body weight). Blood was collected to determine biochemical variables and liver and visceral fat were also obtain for Nesfatin-1/nucleobindin-2 and ghrelin mRNA expressions by using a Real-time PCR technique.A higher and significant nesfatin-1 mRNA expressions in liver and visceral fat and liver estradiol were observed in trained groups. However, the level of ghrelin expression was lower in trained groups when compared to control rats. In general, lower tissues nesfatin-1mRNA expression and lower plasma and higher estradiol HDL-C were observed in bane-treated rats. A negative and positive correlation between liver estradiol and liver ghrelin expression, plasma estradiol, HDL-C and visceral fat nesfatin-1 expression were found respectively. The results of present study indicate that exercise combined with bane-treatment induced considerable changes on liver and visceral fat nesfatin-1 and ghrelin expression which was accompanied with a significant change in plasma HDL-C as a cardiovascular risk factor.

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“…We initiated this work to find the best and most reproducible clinical sample collection treatment to measure acylghrelin in human plasma as well as trends in prandial acylghrelin attenuation. Acylghrelin levels can be influenced by many factors including metabolic stress, natural biorhythms, hormonal changes and lifestyle choices such as diet and level of regular physical activity 28,29 . Regardless of bio‐influences, the importance of properly stabilizing acylghrelin for proper clinical data interpretation is essential.…”

Section: Discussionmentioning

confidence: 99%