2019
DOI: 10.1038/s41526-019-0089-9
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Bridging the gap between military prolonged field care monitoring and exploration spaceflight: the compensatory reserve

Abstract: The concept of prolonged field care (PFC), or medical care applied beyond doctrinal planning timelines, is the top priority capability gap across the US Army. PFC is the idea that combat medics must be prepared to provide medical care to serious casualties in the field without the support of robust medical infrastructure or resources in the event of delayed medical evacuation. With limited resources, significant distances to travel before definitive care, and an inability to evacuate in a timely fashion, medic… Show more

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Cited by 13 publications
(8 citation statements)
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“…In the management of hemorrhagic shock combat-related injuries, the emergency is the etiological treatment of hemorrhage, most often by surgical hemostasis. This is accompanied by measures of vascular filling, regulation of the average arterial pressure, O 2 supply, and fighting against the phenomena of coagulopathy ( Evans et al, 2001 ; Schlotman et al, 2019 ). Despite numerous studies of the pathophysiological mechanisms involving DAMPs, and the dysregulation of immuno-inflammatory and endothelial homeostasis, the only current targeted treatment is the use of corticosteroids.…”
Section: Discussionmentioning
confidence: 99%
“…In the management of hemorrhagic shock combat-related injuries, the emergency is the etiological treatment of hemorrhage, most often by surgical hemostasis. This is accompanied by measures of vascular filling, regulation of the average arterial pressure, O 2 supply, and fighting against the phenomena of coagulopathy ( Evans et al, 2001 ; Schlotman et al, 2019 ). Despite numerous studies of the pathophysiological mechanisms involving DAMPs, and the dysregulation of immuno-inflammatory and endothelial homeostasis, the only current targeted treatment is the use of corticosteroids.…”
Section: Discussionmentioning
confidence: 99%
“…Over the course of the last five to six decades, there has been considerable work trying to understand how spaceflight (radiation and microgravity) affects living systems, with special interest in human medicine [1][2][3] . Studies have shown that the spaceflight environment induces elevated CO2-levels and regional hypoxia in the human brain 2 , which has been linked to lower gray matter volume and changes in vestibular connectivity 4 . Spaceflight can also affect red blood cell mass through a process called 'neocytolysis', which selectively leads to hemolysis of young circulating red blood cells 5,6 .…”
Section: Human Respiratory Health In Spaceflightmentioning
confidence: 99%
“…HR does change only minimally in the early stages, and when finally becoming beyond the “normal” range, the hypovolemic shock has already developed (Secher and Van Lieshout, 2010 ; Schiller et al, 2017 ; Suresh et al, 2018 ). Because of these limitations, several approaches, such as wearable sensors and advanced machine-learning techniques, have been suggested in an attempt to promote more sensitive metrics for the prediction of outcomes in civil patients and on the battlefield (Secher and Van Lieshout, 2005 , 2010 , 2013 , 2016 ; Rickards et al, 2007 , 2008 ; Convertino et al, 2011 , 2020a , b ; Ryan et al, 2011 ; Nadler et al, 2014 ; Schlotman et al, 2019 ; Rashedi et al, 2021 ).…”
Section: Monitoring Cbv In Patientsmentioning
confidence: 99%