Bridging the Chemical Profile and Biomedical Effects of Scutellaria edelbergii Essential Oils

Shah, Muddaser; Bibi, Shabana; Kamal, Zul; Al-Sabahi, Jamal Nasser; Alam, Tanveer; Ullah, Obaid; Murad, Waheed; Rehman, Najeeb Ur; Al‐Harrasi, Ahmed

doi:10.3390/antiox11091723

Cited by 7 publications

(11 citation statements)

References 112 publications

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“…Plants and their products are an alternative source of innovative drugs. Hence, to authenticate and highlight their importance, the E. larica essential oil was screened against the human pathogenic microbes using agar well diffusion techniques, and ZOIs were measured [ 41 ]. The microbial strains (clinical isolates) were identified by Dr. Hazir Rahman, Department of Microbiology, AWKUM, Mardan.…”

Section: Methodsmentioning

confidence: 99%

“…The ELEO was screened against the bacterial strains S. typhi , K. pneumonia , B. atrophaeus , and B. subtilis via agar well diffusion (AWD) techniques [ 41 , 42 ]. For the antibacterial valuation, the media were arranged by adding 28 g of nutrient agar (NA) media along with 1 L of distilled water (DW) and shaken until the media was entirely homogenized.…”

Section: Methodsmentioning

confidence: 99%

“…The ELEO was examined for its antifungal capabilities against A. parasiticus and A. niger from low to high doses via an agar well diffusion technique [ 41 , 42 ]. The antifungal activity was carried out by adding 39 g of the potato dextrose agar (PDA) to 1 L of distilled water in a glass conical flask and shaken until homogenized.…”

Section: Methodsmentioning

confidence: 99%

“…The ELEO was examined for its antioxidant significance using a DPPH bioassay [ 41 , 43 ]. The antioxidant assay proceeded by homogenizing 3 mg DPPH with 100 mL of distilled methanol (DM).…”

Section: Methodsmentioning

confidence: 99%

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GC-MS Profiling and Biomedical Applications of Essential Oil of Euphorbia larica Boiss.: A New Report

et al. 2023

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The present study explored Euphorbia larica essential oil (ELEO) constituents for the first time, obtained via hydro-distillation by means of Gas Chromatography-Mass Spectrometry (GC-MS) profiling. The essential oil was screened in vitro against breast cancer cells, normal cell lines, α-glucosidase, carbonic anhydrase-II (CA-II), free radical scavenging and in vivo analgesic and anti-inflammatory capabilities. The GC-MS screening revealed that the ELEO comprises sixty compounds (95.25%) with the dominant constituents being camphene (16.41%), thunbergol (15.33%), limonene (4.29%), eremophilene (3.77%), and β-eudesmol (3.51%). A promising antidiabetic capacity was noticed with an IC50 of 9.63 ± 0.22 μg/mL by the ELEO as equated to acarbose with an IC50 = 377.71 ± 1.34 μg/mL, while a 162.82 ± 1.24 μg/mL inhibition was observed against CA-II. Regarding breast cancer, the ELEO offered considerable cytotoxic capabilities against the triple-negative breast cancer (MDA-MB-231) cell lines, having an IC50 = 183.8 ± 1.6 μg/mL. Furthermore, the ELEO was also tested with the human breast epithelial (MCF-10A) cell line, and the findings also presumed that the ELEO did not produce any damage to the tested normal cell lines. The ELEO was effective against the Gram-positive bacteria and offered a 19.8 ± 0.02 mm zone of inhibition (ZOI) against B. atrophaeus. At the same time, the maximum resistance with 18.03 ± 0.01 mm ZOI against the fungal strain Aspergillus parasiticus was observed among the tested fungal strains. An appreciable free radical significance was observed via the DPPH assay with an IC50 = 133.53 ± 0.19 µg/mL as equated to the ABTS assay having an IC50 = 154.93 ± 0.17 µg/mL. The ELEO also offered a substantial analgesic capacity and produced 58.33% inhibition in comparison with aspirin, a 68.47% decrease in writhes, and an anti-inflammatory capability of 65.54% inhibition, as equated to the standard diclofenac sodium having 73.64% inhibition. Hence, it was concluded that the ELEO might be a natural source for the treatment of diabetes mellitus, breast cancer, analgesic, inflammatory, and antimicrobial-related diseases. Moreover, additional phytochemical and pharmacological studies are needed to isolate responsible chemical ingredients to formulate new drugs for the examined activities.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The ELEO was examined for its antioxidant significance using a DPPH bioassay [ 41 , 43 ]. The antioxidant assay proceeded by homogenizing 3 mg DPPH with 100 mL of distilled methanol (DM).…”

Section: Methodsmentioning

confidence: 99%

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GC-MS Profiling and Biomedical Applications of Essential Oil of Euphorbia larica Boiss.: A New Report

et al. 2023

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“…Plant based natural products, comprising essential oils (EOs) have gained attention due to their usage in foodstuff, cosmetics, and pharmaceutical productions. Constituting a range of several lipophilic and extremely volatile constituents, obtained from an extensive range of diverse chemical classes, EOs are attributed to multiple health benefits: analgesic, anti-inflammatory, antioxidant, antimicrobial, anticancer, and antidiabetic [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

First Report on Comparative Essential Oil Profile of Stem and Leaves of Blepharispermum hirtum Oliver and Their Antidiabetic and Anticancer Effects

et al. 2022

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The current research was designed to explore the Blepharispermum hirtum Oliver (Asteraceae) stem and leaves essential oil (EO) composition extracted through hydro-distillation using gas chromatography-mass spectrometry (GC-MS) analysis for the first time. The EOs of the stem and leaves of B. hirtum were comparatively studied for the in vitro antidiabetic and anticancer potential using in vitro α-glucosidase and an MTT inhibition assay, respectively. In both of the tested samples, the same number of fifty-eight compounds were identified and contributed 93.88% and 89.07% of the total oil composition in the EOs of the stem and leaves of B. hirtum correspondingly. However, camphene was observed as a major compound (23.63%) in the stem EO, followed by β-selinene (5.33%) and β-elemene (4.66%) and laevo-β-pinene (4.38%). While in the EO of the leaves, the dominant compound was found to be 24-norursa-3,12-diene (9.08%), followed by β-eudesmol (7.81%), β-selinene (7.26%), thunbergol (5.84%), and caryophyllene oxide (5.62%). Significant antidiabetic potential was observed with an IC50 of 2.10 ± 0.57 µg⁄mL by the stem compared to the EO of the leaves of B. hirtum, having an IC50 of 4.30 ± 1.56 µg⁄mL when equated with acarbose (IC50 = 377.71 ± 1.34 µg⁄mL). Furthermore, the EOs offered considerable cytotoxic capabilities for MDA-MB-231. However, the EO of the leaves presented an IC50 = 88.4 ± 0.5 μg/mL compared to the EO of the stem of B. hirtum against the triple-negative breast cancer (MDA-MB-231) cell lines with an IC50 = 123.6 ± 0.8 μg/mL. However, the EOs were also treated with the human breast epithelial (MCF-10A) cell line, and from the results, it has been concluded that these oils did not produce much harm to the normal cell lines. Hence, the present research proved that the EOs of B. hirtum might be used to cure diabetes mellitus and human breast cancer. Moreover, further studies are considered to be necessary to isolate the responsible bioactive constituents to devise drugs for the observed activities.

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Evaluating Antibiofilm, Cytotoxic and Apoptotic Activities of Scutellaria brevibracteata subsp. brevibracteata Essential Oil

Kart,

Günal,

Mutlu

et al. 2023

Chemistry & Biodiversity

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Essential oils have many important biological properties, including antibacterial and antibiofilm activities. These unique properties make, essential oils good alternatives to synthetic chemical drugs, which have many side effects. In this study, we aimed to determine the chemical composition and biological activity of the essential oil obtained from Scutellaria brevibracteata subsp. brevibracteata. Specifically, its antibiofilm activity against Pseudomonas aeruginosa PAO1 and Staphylococcus aureus ATCC 29213 biofilms using XTT assay. Cytotoxic and apoptotic properties of the essential oil were investigated in human lung cancer cells (A540 and H1299) using MTT assay, Annexin V‐FITC and propidium iodide staining and q‐PCR. Thirty‐two different compounds were identified from the essential oil, of which elemol (20.42%), γ‐eudesmol (20.12%) and β‐eudesmol (14.85%) were the main components. The essential oil was more effective against P. aeruginosa PAO1 biofilm (79%) than S. aureus ATCC 29213 biofilm (27%). The specific activity of the essential oil against P. aeruginosa biofilm may be related to its high terpene contents. In addition, the essential oil showed high cytotoxic activity towards A549 (IC50 9.09 µg/ml) and H1299 (IC50 55.04 µg/ml) cell lines, inducing apoptosis in these cancer cells. These results demonstrate the antibiofilm and anticancer activities of S. brevibracteata subsp. brevibracteata essential oil.

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Bridging the Chemical Profile and Biomedical Effects of Scutellaria edelbergii Essential Oils

Cited by 7 publications

References 112 publications

GC-MS Profiling and Biomedical Applications of Essential Oil of Euphorbia larica Boiss.: A New Report

GC-MS Profiling and Biomedical Applications of Essential Oil of Euphorbia larica Boiss.: A New Report

First Report on Comparative Essential Oil Profile of Stem and Leaves of Blepharispermum hirtum Oliver and Their Antidiabetic and Anticancer Effects

Evaluating Antibiofilm, Cytotoxic and Apoptotic Activities of Scutellaria brevibracteata subsp. brevibracteata Essential Oil

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