Bretylium Tosylate in the Treatment of Hypertension

Some Clinical Experiences with Guanethidine: A New Hypotensive Agent

“…As regards the other forms of combined treatment, it seems that guanethidine can be suitably combined with hydralazine. Three cases (3,11,12) that were previously not able to tolerate hydralazine even in small doses on account of palpitations of the heart and headache, were able to stand hydralazine better when combined with guanethidine. This is possibly due to the fact that the bradycardia1 effect of guanethidine offsets the tachycardia obtained by hydralazine medication.…”

Sympathetic Blockade in Treatment of Hypertension

“…There has been no recurrence on guanethidine. Other workers have experienced a higher incidence of mental changes (Evanson and Sears, 1960).…”

Bretylium Tosylate in Treatment of Severe Hypertension

“…Introduced by Boura et al (1959), bretylium tosylate blocks the sympathetic nervous system by its selective accumulation in sympathetic ganglia and post-ganglionic sympathetic fibres. Following on encouraging reports of clinical trials (Boura et al, 1959;Dollery et al, 1960a) there has been a considerable correspondence Lowther, 1960a, 1960b;Evanson and Sears, 1960;Lowe and Rosenheim, 1960;Somers, 1960a) recording unfavourable experiences with bretylium. Ultimately Dollery et al (1960b) abandoned the use of bretylium because of the high incidence of drug resistance.…”