Breed differences in sheep with respect to the interaction between zinc and the accumulation of copper in the liver

Schee, Wilke van der; Assem, G. H. van den; Berg, R. van der

doi:10.1080/01652176.1983.9693892

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…Moreover, total hepatic Cu and Zn concentrations were correlated in all animals (Figure 1). As Cu and Zn are chemically similar, a competitive interaction has frequently been described [30,38], including a decrease in Cu intestinal absorption in Zn-dosed animals in the present study. However, the interaction between both elements in the liver was positive in our study and did not seem to be associated with the proportion of these elements bound to MT.…”

Section: Discussionsupporting

confidence: 63%

“…Thus, although the usefulness of Zn for protecting sheep against CCP has been demonstrated [28], no change in the hepatic Cu load was observed in sheep administered Zn therapy [29]. Moreover, breed differences have been described in sheep in relation to the interaction between Zn and Cu accumulation in the liver [30] and may be related to genetic differences in the capacity for MT to bind Cu and Zn.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep

Minervino

López‐Alonso

Júnior

et al. 2018

Animals

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Simple SummarySheep are susceptible to copper toxicosis, a deadly disease that usually occurs when the animals ingest large amounts of this mineral. Considering that the susceptibility of sheep to copper accumulation varies widely among breeds and from animal to animal., we evaluate whether Zn supplementation could be an option as a preventive measure to protect against hepatic Cu accumulation in sheep. Zn at 300 mg/kg dry matter (DM) is useful for preventing excessive hepatic Cu accumulation. Hepatic Cu accumulation is lower in animals receiving the Zn supplementation.AbstractThe aim of this study was to evaluate whether zinc (Zn) supplementation protects against hepatic copper (Cu) accumulation in copper-loaded sheep. Forty cross-bred lambs were assigned to five experimental groups. These included the control group (C) and four treatment groups that received Cu and/or Zn supplementation (dry matter (DM) basis) over 14 weeks, as follows: Cu (450 mg Cu/kg); Zn-35 (450 mg Cu + 35 mg Zn/kg); Zn-150 (450 mg Cu + 150 mg Zn/kg); and Zn-300 (450 mg Cu + 300 mg Zn/kg). Blood, liver, and bile samples were obtained for mineral determination by inductively coupled plasma optical emission spectrometry (ICP–OES). The hepatic metallothionein (MT) concentrations were also determined. At the end of the experiment, hepatic Cu concentrations were higher in all Cu-supplemented groups than in C. Hepatic Cu accumulation was lower in the groups receiving the Zn supplementation than in the Cu group, although the difference was only statistically significant (66%) in the Zn-300 group. The MT concentrations tended to be higher (almost two-fold) in the Zn groups (but were not dose related) than in the C and Cu groups, and they were related to hepatic Zn concentrations. Zn supplementation at 300 mg/kg DM is useful for preventing excessive hepatic Cu accumulation in sheep exposed to high dietary concentrations of Cu.

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep

Minervino

López‐Alonso

Júnior

et al. 2018

Animals

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“…Wool production imposes a high demand for minerals (Grace and Clark, 1991;Neathery et al, 1972;White et al, 1994). Different breeds of sheep have differences in Cu and Zn metabolism (e.g., Van der Schee et al, 1983). Our analysis on the occurrence of skin lesions between two different alpaca breeds could not clarify whether such breed differences occur in South American camelids as well, due to the uneven distribution of fleece colours and breeds in our sample.…”

mentioning

confidence: 89%

Skin lesions in alpacas and llamas with low zinc and copper status – a preliminary report

Clauss¹,

Lendl²,

Schramel

et al. 2004

The Veterinary Journal

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“…Intakes of Zn impacts on Cu utilisation [18]. An increase of dietary Zn in lambs diet from 45 mg/kg DW to 225 and 479 mg/kg DW reduced concentrations of Cu liver from 1625 to 1310 and 1158 mg/kg DW respectively [19]. The mechanism underlying the metabolic Cu-Zn interaction has been proposed to potentially involve Metallothionein (MT) as Zn is suggested to induce MT [20].…”

Section: Ovine and Bovinementioning

confidence: 99%

Assessment of Hepatic Mineral Composition in Sheep, Cattle, Chicken, and Fish in Erbil City, Kurdistan Region-Iraq

Hussein¹,

Omer²,

Ali³

et al. 2021

KJAR

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Liver mineral concentrations of 232 samples from slaughtered animals, including lamb, yearling, sheep, and cattle, checkin, and fish were detrmined, using X-ray fluorescence spectrometer, to provide data regarding to the liver mineral concentrations (mg/kg dry weight). The mean liver Zn and Co liver conentrations of lambs (286, 1.9), yearling (233, 1.7), sheep (254, 1.8), and cattle (276, 1.8) in majority samples were adequate, while liver Pb concentrations of mentioned animals (45.3, 48.1, 46.4, 39.6) mg/kg respectively were high and exceeded toxic levels. In checkin, the mean liver Cu, Zn, and Co were also adequate, with the mean values of (26.4), (298.8), and (1.8) mg/kg respectively. Though, the mean liver Fe concentration (2257.0 mg/kg) was high, and liver Pb concentration (6.2 mg/kg) was reched toxic level. In fish, for majority liver samples, the mean concentration of Cu (191.8), Fe (6800.0), Zn (202.8), Co (3.3), Pb (8.6), and Ni (6.3) were high and toxic. In conclusion, liver Pb (and Ni only in fish) concentration in all studied animals for the majority of examined sample were higher than normal and toxic. Wherese, other studied minerals in majority of liver samples were adequate. Therefore, it can be concluded that there are problems on animal and human health (due to high concentration of Pb and Ni) would be raised at present from the consumption of ovine, bovine, checkin, and fish slaughtered from the city of Erbil.

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Breed differences in sheep with respect to the interaction between zinc and the accumulation of copper in the liver

Cited by 8 publications

References 11 publications

Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep

Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep

Skin lesions in alpacas and llamas with low zinc and copper status – a preliminary report

Assessment of Hepatic Mineral Composition in Sheep, Cattle, Chicken, and Fish in Erbil City, Kurdistan Region-Iraq

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