Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep

Minervino, Antônio Humberto Hamad; López‐Alonso, Marta; Júnior, Raimundo Alves Barrêto; Rodrigues, Frederico Augusto Mazzocca Lopes; Araújo, Carolina Akiko Sato Cabral; Sousa, Rejane Santos; Mori, Clara Satsuki; Miranda, Marta; Oliveira, Francisco Leonardo Costa; Antonelli, Alexandre Coutinho; Ortolani, Enrico Lippi

doi:10.3390/ani8120227

Cited by 28 publications

(27 citation statements)

References 47 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The correlation analyses regarding Zn tissue concentration showed a strong positive correlation between Zn concentrations in the pancreas and each small intestinal segment, which confirms the important role of the pancreas in the endogenous excretion and reutilisation of zinc, as well as for Zn homeostasis. Zn, Cu and Fe are chemically similar, so the interaction among the elements appears to be tissue-specific and a positive correlation has been found between total Zn and Cu concentrations, mainly in liver and kidney tissues [40,41]. We found a positive correlation between Zn and Cu content in the kidney and ileum.…”

Section: Discussionsupporting

confidence: 52%

“…Liver SOD activity is sensitive to changes in Cu status and the increase in SOD activity is associated with an increased Cu content. Cu may not be safely bound in liver and acts as a pro-oxidant, leading to an increase in Cu/Zn superoxide dismutase activity in the tissue [39,40,41]. Moreover, a positive correlation between Cu/Zn SOD activity and Cu concentration in liver tissue was recorded in our study.…”

Section: Discussionmentioning

confidence: 57%

See 1 more Smart Citation

Dietary Zinc and Fibre Source can Influence the Mineral and Antioxidant Status of Piglets

Holodová

Čobanová

Šefčíková

et al. 2019

Animals

View full text Add to dashboard Cite

The study investigated the effect of dietary zinc glycine chelate and potato fibre on the absorption and utilisation of Zn, Cu, Fe, and Mn; the activity of Zn-containing enzymes (superoxide dismutase, SOD; alkaline phosphatase, ALP); and zinc transporter concentrations (metalothionein1, MT1; zinc transporter1, ZnT1) in tissues, with a special emphasis on the small intestine. Twenty-four barrows (Danbred × Duroc) were randomly allotted to four diets (supplemented with 10 g/kg of crude fibre and 120 mg Zn/kg) that consisted of cellulose and either zinc sulphate (C) or zinc glycinate (ZnGly), or contained potato fibre supplemented with ZnSO4 (PF) or ZnGly (PF + ZnGly). Feeding PF can influence the Zn absorption in the small intestine due to reduced zinc transporters MT1 and ZnT1 in the jejunum. The activity of antioxidant enzyme SOD and liver ZnT1, and duodenal iron concentrations were increased in the PF treatments. Dietary ZnGly did not significantly influence the Zn distribution, but it may alter the absorption of Fe and Mn. Given the elevated content of thiol groups and the Zn/Cu ratio in plasma, as well as the altered SOD activity and MT content in the tissues, we can conclude that feeding PF and ZnGly can influence the mineral and antioxidant status of growing piglets. However, further research is needed in order to elucidate the effect of both dietary sources on the transport systems of other minerals in enterocytes.

show abstract

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 57%

Dietary Zinc and Fibre Source can Influence the Mineral and Antioxidant Status of Piglets

Holodová

Čobanová

Šefčíková

et al. 2019

Animals

View full text Add to dashboard Cite

show abstract

“…Trace element determination in biological and environmental samples continues to be a challenge due to the low concentrations involved and the undesired matrix effects produced by other sample components. In addition to the elements commonly considered toxic (namely As, Cd, Pb and Hg), other metals have been identified as potentially toxic, and at least seventeen essential trace elements can be toxic when consumed in excess [1–3]. In both animals and humans, low and/or high trace element concentrations in tissues are directly related to the pathogenesis of numerous diseases; for example, elevated concentrations of Fe and Cu (capable of inducing oxidative damage) are detected in the brain tissues of Alzheimer’s patients and in the brains of humans and animals affected by other neurological disorders [4–6].…”

Section: Introductionmentioning

confidence: 99%

Validation of a simple sample preparation method for multielement analysis of bovine serum

et al. 2019

Self Cite

View full text Add to dashboard Cite

Here we propose a single acid digestion (SAD) sample preparation method for ICP-MS analysis of animal serum samples to determine trace element contents. The method was evaluated in comparison with a commonly used procedure involving dilution of samples in an alkaline solution (AKD). In the SAD procedure, aliquots (1 mL) of bovine serum samples were treated at low temperature with a mixture of concentrated nitric acid and hydrogen peroxide. Trace elements (As, B, Ba, Cd, Co, Cr, Cu, Fe, Hg, Li, Mn, Mo, Ni, Pb, Sb, Se, Sr, U, and Zn) were directly determined by ICP-MS analysis of diluted solutions of samples. Both methods were sufficiently sensitive to enable quantification of most trace elements, with the exception of the AKD method for Cd, Hg and Pb. The quality of the data was verified by using certified reference material. Good results were obtained for the SAD procedure and all elements, but recoveries were unacceptable with the AKD procedure for Se (recovery: 57%), Cd (154%) and Fe (139%). Strong associations (R2>0.90, P = 0.000) between the data obtained by both methods were demonstrated for the elements considered. The proposed SAD sample preparation method produced satisfactory results for determining most toxic and essential trace elements targeted in monitoring studies.

show abstract

“…Serum and urine also samples were used to determine chromium concentration via digestion with chromium-free nitric acid and perchloric acid solutions (4:1 v/v), which were analyzed using optical spectrophotometry by plasma emission (Varian  , Saint Claire, USA) (Minervino et al 2018).…”

Section: Methodsmentioning

confidence: 99%

Influence of organic chromium supplementation on the performance of beef calves undergoing weaning-related stress

Sousa

Mori

et al. 2020

Pesq. Vet. Bras.

View full text Add to dashboard Cite

ISSN 0100-736X (Print) ISSN 1678-5150 (Online) RESUMO.-[Influência da suplementação com cromo orgânico no desempenho de bezerros de corte submetidos ao estresse da desmama.] O estudo foi realizado para avaliar a hipótese de que a suplementação dietética com cromo antes, durante e após a desmama possa diminuir a concentração de cortisol causado por este processo em bezerros de corte. Para tal, foram utilizados 150 bezerros mestiços, machos e fêmeas, entre cinco e seis meses de idade. Os animais foram divididos randomicamente por sexo e grupo genético em dois grupos homogêneos (n=75), um mantido como controle e outro suplementado com 0,9mg de carboaminofosfoquelato de cromo/100 kg PV misturado a um sal proteinado para ser consumido na base de 0,1% do PV via creep feeding, no decorrer de 60 dias antes e 60 dias após à desmama forçada. Os animais foram pesados e foram coletadas amostras sanguíneas e urinárias no M0 (60 dias antes da desmama), M1 (desmama), M2 (48 horas após a desmama) e M3 (60 dias após à desmama) para determinação de cromo, cortisol, proteína total e albumina no sangue e da concentração urinária de creatinina e cromo. O ganho acumulado de peso foi superior nos bezerros suplementados com cromo antes da desmama e no decorrer de todo o experimento (P<0,05). A suplementação com cromo reduziu ABSTRACT.-Sousa I.Ortolani E.L. 2020. Influence of organic chromium supplementation on the performance of beef calves undergoing weaning-related stress. Pesquisa Veterinária Brasileira 40(2)97-101. Dietary chromium supplementation before, during, and after weaning was conducted to evaluate the hypothesis that chromium supplementation could reduce weaning-induced cortisol release in beef calves. We examined the effects of chromium supplementation in 150 crossbred calves (male and female) between five and six months of age. The calves were randomly divided by sex and breed into two equal homogeneous groups (n=75). One group was used as the control, and the other experimental group received supplementation with 0.9mg of chromium carbon-amino-phospho-chelate per 100kg BW. The chromium supplement was mixed with mineral salt for the consumption of 0.1% of BW, and the supplement was administered via creep feeding 60 days before and 60 days after forced weaning. Calves were weighed, and their blood and urine samples were obtained at four time-points: T0 (60 days before weaning), T1 (at weaning), T2 (48 hours after weaning), and T3 (60 days after weaning). Blood samples were used to determine chromium, cortisol, total protein, and albumin concentrations, and urine samples were used to determine urinary creatinine and chromium levels. Cumulative weight gain was higher in calves supplemented with chromium before weaning and during the experiment (P<0.05). In addition, weaning-related stress caused an increase in chromium excretion in the urine, and chromium supplementation reduced stress, which resulted in lower cortisol and total protein levels during weaning.

show abstract

Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep

Cited by 28 publications

References 47 publications

Dietary Zinc and Fibre Source can Influence the Mineral and Antioxidant Status of Piglets

Dietary Zinc and Fibre Source can Influence the Mineral and Antioxidant Status of Piglets

Validation of a simple sample preparation method for multielement analysis of bovine serum

Influence of organic chromium supplementation on the performance of beef calves undergoing weaning-related stress

Contact Info

Product

Resources

About