Breathable, stretchable and adhesive nanofibrous hydrogels as wound dressing materials

Liu, Xueting; Liu, Yumin; Du, Jingtao; Li, Xiaoran; Yu, Jianyong; Ding, Bin

doi:10.1016/j.engreg.2021.05.001

Cited by 29 publications

(22 citation statements)

References 33 publications

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“…[ 3 ] The overexpressed ROS will result in oxidative stress, which causes lipids, proteins, and DNA damage in cells, thus inducing cell death and triggering deleterious processes such as necrosis, inflammation, and fibrotic scarring. [ 4 , 5 ] Since the critical role of the impaired angiogenesis and overexpressed ROS, [ 6 ] the attempts to promote diabetic wound healing have focused on the development of an effective treatment approach based on multifunctional biomaterials, [ 7 , 8 , 9 , 10 ] which could simultaneously attenuate the oxidative stress, as well as promote angiogenesis at the wound sites. [ 11 ] Although with many successes, most of the existing biomaterials are merely encapsulating growth factors for inducing angiogenesis or delivering antioxidants for scavenging the ROS overexpression, which is still limited in comprehensively handling the complicated process in wound healing.…”

Section: Introductionmentioning

confidence: 99%

Polydopamine Decorated Microneedles with Fe‐MSC‐Derived Nanovesicles Encapsulation for Wound Healing

et al. 2022

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Wound dressing with the capacities of antioxidation, antiinflammation, and efficient angiogenesis induction is expected for effectively promoting wound healing. Herein, a novel core‐shell hyaluronic acid (HA) microneedle (MN) patch with ferrum‐mesenchymal stem cell‐derived artificial nanovesicles (Fe‐MSC‐NVs) and polydopamine nanoparticles (PDA NPs) encapsulated in the needle tips is presented for wound healing. Fe‐MSC‐NVs containing multifunctional therapeutic cytokines are encapsulated in the inner HA core of the MN tips for accelerating angiogenesis. The PDA NPs are encapsulated in the outer methacrylated hyaluronic acid (HAMA) shell of the MN tips to overcome the adverse impacts from reactive oxygen species (ROS)‐derived oxidative stress. With the gradual degradation of HAMA patch tips in the skin, the PDA NPs are sustainably released at the lesion to suppress the ROS‐induced inflammation reaction, while the Fe‐MSC‐NVs significantly increase the migration, proliferation, and tube formation of human umbilical vein endothelial cells (HUVEC). More attractively, the combination of PDA NPs and Fe‐MSC‐NVs further promotes M2 macrophage polarization, thereby suppressing wound inflammation. Through in vivo experiment, the Fe‐MSC‐NVs/PDA MN patch shows an excellent effect for diabetic wound healing. These features of antioxidation, antiinflammation, and pro‐angiogenesis indicate the proposed composite core‐shell MN patch is valuable for clinical wound healing applications.

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Section: Introductionmentioning

confidence: 99%

Polydopamine Decorated Microneedles with Fe‐MSC‐Derived Nanovesicles Encapsulation for Wound Healing

et al. 2022

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“…Generally, a lower concentration of GelMA hydrogel has a larger pore size and higher porosity, which have a positive effect on the proliferation, differentiation, migration, and adhesion of cells attached or encapsulated in it [ 28 – 30 ]. However, with the decrease of GelMA concentration, the mechanical property of hydrogel decreased, leading to nanopore collapse, making it difficult to prepare the hierarchical hydrogel with ordered micro-nano structure.…”

Section: Resultsmentioning

confidence: 99%

Hierarchical Hydrogels with Ordered Micro-Nano Structures for Cancer-on-a-Chip Construction

et al. 2021

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In the drug therapy of tumor, efficient and stable drug screening platforms are required since the drug efficacy varies individually. Here, inspired by the microstructures of hepatic lobules, in which hepatocytes obtain nutrients from both capillary vessel and the central vein, we present a novel hierarchical hydrogel system with ordered micro-nano structure for liver cancer-on-a-chip construction and drug screening. The hierarchical hydrogel system was fabricated by using pregel to fill and replicate self-assembled colloidal crystal arrays and microcolumn array template. Due to the synergistic effect of its interconnected micro-nano structures, the resultant system could not only precisely control the size of cell spheroids but also realize adequate nutrient supply of cell spheroids. We have demonstrated that by integrating the hierarchical hydrogel system into a multichannel concentration gradients microfluidic chip, a functional liver cancer-on-a-chip could be constructed for high-throughput drug screening with good repeatability and high accuracy. These results indicated that the hierarchical hydrogel system and its derived liver cancer-on-a-chip are ideal platforms for drug screening and have great application potential in the field of personalized medicine.

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“…[ 11 , 12 , 13 , 14 , 15 , 16 , 17 ] Photonic bandgaps (PBGs) arisen from these ordered structures endow PhC codes with characteristic reflection peaks for applications in various fields including multiplexed detection, anti‐counterfeiting, and so on. [ 18 , 19 , 20 , 21 , 22 , 23 ] Despite with many progresses, the majority of PhCs utilized for information coding are angle dependent, which would cause inconsistence of the obtained message from different observing angles. [ 24 ] Besides, most of the information hidden by PhCs could be easily distinguished through observing structural colors and analyzing reflection spectra, which may lead to information leakage.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Perovskite Nanocrystals‐Integrated Photonic Crystal Microsphere Arrays for Information Security

et al. 2022

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Information security occupies an important position in the era of big data. Attempts to improve the security performance tend to impart them with more additional encryption strategies. Herein, inspired by the wettability feature of Stenocara beetle elytra and signal model of traffic light, a novel array of perovskite nanocrystals (PNs)‐integrated PhC microsphere for information security is presented. The photoluminescent PNs are encapsulated in angle‐independent PhC microspheres to impart them with binary optical signals as coding information. Through the multimask superposition approach, PNs‐integrated PhC microspheres with different codes are placed into fluorosilane‐treated PDMS substrate to form different arrays. These arrays could converge moisture on PhC microspheres in wet environment, which avoids the ions loss of the PNs and effectively prevented mutual contamination. In addition, the fluorescence of the PNs inside PhC microspheres could reversibly quench or recover in response to the environmental moisture. Based on these features, it is demonstrated that the PNs‐integrated PhC microsphere arrays could realize various information encryption modes, which indicate their excellent values in information security fields.

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Breathable, stretchable and adhesive nanofibrous hydrogels as wound dressing materials

Cited by 29 publications

References 33 publications

Polydopamine Decorated Microneedles with Fe‐MSC‐Derived Nanovesicles Encapsulation for Wound Healing

Polydopamine Decorated Microneedles with Fe‐MSC‐Derived Nanovesicles Encapsulation for Wound Healing

Hierarchical Hydrogels with Ordered Micro-Nano Structures for Cancer-on-a-Chip Construction

Bioinspired Perovskite Nanocrystals‐Integrated Photonic Crystal Microsphere Arrays for Information Security

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