Breath air analysis and its use as a biomarker in biological monitoring of occupational and environmental exposure to chemical agents

Amorim, Leiliane Coelho André; Cardeal, Zenilda de Lourdes

doi:10.1016/j.jchromb.2007.03.023

Cited by 70 publications

(45 citation statements)

References 50 publications

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“…This technique has the advantage for clinical purposes that there is no contamination from the dead-space volume. Moreover, the concentration of endogenous substances is 1-3 times greater than in mixed expiratory samples [17,49]. As a result, it is easy to identify and to quantify blood-borne substances.…”

Section: Breath-sampling Proceduresmentioning

confidence: 99%

“…Although there is as yet no solid evidence of a health risk at the low levels normally detected in homes (from a few g/m 3 to ng/m 3 ), some VOCs are well-established carcinogens and others, due to poorly understood mechanisms, may be allergenics [32]. Unfortunately, the few epidemiological studies conducted in these conditions have given us insufficient data to elucidate any possible relationship between exposure to VOCs in non-industrial environments and their effect on human health [33], even in the case of repeated, prolonged contact [17].…”

Section: Introductionmentioning

confidence: 99%

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Analytical challenges in breath analysis and its application to exposure monitoring

Alonso

Sánchez

2013

TrAC Trends in Analytical Chemistry

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There is an increasing interest in the use of breath analysis for monitoring human physiology and exposure to toxic substances or environmental pollutants.This review focuses on the current status of the sampling procedures, collection devices and sample-enrichment methodologies used for exhaled breath-vapor analysis. We discuss the different parameters affecting each of the above steps, taking into account the requirements for breath analysis in exposure assessments and the need to analyze target compounds at sub-ppbv levels.Finally, we summarize the practical applications of exposure analysis in the past two decades.

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Section: Breath-sampling Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analytical challenges in breath analysis and its application to exposure monitoring

Alonso

Sánchez

2013

TrAC Trends in Analytical Chemistry

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“…Studies have been developed using HS-SPME in order to establish the volatile composition of human exhaled breath [8] or for a specific type of disease, for example diabetes [14], lung cancer [15] and cystic fibrosis [16] or for chemical substances exposure monitoring [17]. Studies concerning non invasive monitoring of allergic airway inflammation have been made using exhaled nitric oxide [18] or breath condensate [19].…”

Section: Introductionmentioning

confidence: 99%

Profiling allergic asthma volatile metabolic patterns using a headspace-solid phase microextraction/gas chromatography based methodology

Caldeira

Barros

Bilelo³

et al. 2011

Journal of Chromatography A

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a b s t r a c tAllergic asthma represents an important public health issue with significant growth over the years, especially in the paediatric population. Exhaled breath is a non-invasive, easily performed and rapid method for obtaining samples from the lower respiratory tract. In the present manuscript, the metabolic volatile profiles of allergic asthma and control children were evaluated by headspace solid-phase microextraction combined with gas chromatography-quadrupole mass spectrometry (HS-SPME/GC-qMS). The lack of studies in breath of allergic asthmatic children by HS-SPME led to the development of an experimental design to optimize SPME parameters. To fulfil this objective, three important HS-SPME experimental parameters that influence the extraction efficiency, namely fibre coating, temperature and time extractions were considered. The selected conditions that promoted higher extraction efficiency corresponding to the higher GC peak areas and number of compounds were: DVB/CAR/PDMS coating fibre, 22 • C and 60 min as the extraction temperature and time, respectively. The suitability of two containers, 1 L Tedlar ® bags and BIOVOC ® , for breath collection and intra-individual variability were also investigated. The developed methodology was then applied to the analysis of children exhaled breath with allergic asthma (35), from which 13 had also allergic rhinitis, and healthy control children (15), allowing to identify 44 volatiles distributed over the chemical families of alkanes (linear and ramified) ketones, aromatic hydrocarbons, aldehydes, acids, among others. Multivariate studies were performed by Partial Least Squares-Discriminant Analysis (PLS-DA) using a set of 28 selected metabolites and discrimination between allergic asthma and control children was attained with a classification rate of 88%. The allergic asthma paediatric population was characterized mainly by the compounds linked to oxidative stress, such as alkanes and aldehydes. Furthermore, more detailed information was achieved combining the volatile metabolic data, suggested by PLS-DA model, and clinical data.

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“…21,22 Furthermore, these methods often require a presampling step to increase the relative concentration of breath VOCs to detectable levels. 2,23 Therefore, the development of highly efficient, sensitive, simple, inexpensive, and reliable breath sensing devices is essential for early diagnosis of cancer disease by breath analysis.…”

Section: Introductionmentioning

confidence: 99%

Core-shell nanostructured hybrid composites for volatile organic compound detection

An¹,

Tùng²,

Lošić³

et al. 2015

IJN

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We report a high-performance chemiresistive sensor for detection of volatile organic compound (VOC) vapors based on core-shell hybridized nanostructures of Fe 3 O 4 magnetic nanoparticles (MNPs) and poly(3,4-ethylenedioxythiophene) (PEDOT)-conducting polymers. The MNPs were prepared using microwave-assisted synthesis in the presence of polymerized ionic liquids (PILs), which were used as a linker to couple the MNP and PEDOT. The resulting PEDOT–PIL-modified Fe 3 O 4 hybrids were then explored as a sensing channel material for a chemiresistive sensor to detect VOC vapors. The PEDOT–PIL-modified Fe 3 O 4 sensor exhibited a tunable response, with high sensitivity (down to a concentration of 1 ppm) and low noise level, to VOCs; these VOCs include acetone vapor, which is present in the exhaled breath of potential lung cancer patients. The present sensor, based on the hybrid nanostructured sensing materials, exhibited a 38.8% higher sensitivity and an 11% lower noise level than its PEDOT–PIL-only counterpart. This approach of embedding MNPs in conducting polymers could lead to the development of new electronic noses, which have significant potential for the use in the early diagnosis of lung cancer via the detection of VOC biomarkers.

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Breath air analysis and its use as a biomarker in biological monitoring of occupational and environmental exposure to chemical agents

Cited by 70 publications

References 50 publications

Analytical challenges in breath analysis and its application to exposure monitoring

Analytical challenges in breath analysis and its application to exposure monitoring

Profiling allergic asthma volatile metabolic patterns using a headspace-solid phase microextraction/gas chromatography based methodology

Core-shell nanostructured hybrid composites for volatile organic compound detection

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