Breastfeeding and the anthropometric profile of children with sickle cell anemia receiving follow-up in a newborn screening reference service

Nogueira, Zeni Drubi; Boa‐Sorte, Ney; Leite, Maria Efigênia de Queiroz; Kiya, Márcia Miyuki; Amorim, Tatiana; Fonseca, Silvana Fahel da

doi:10.1016/s2359-3482(15)30045-2

Cited by 4 publications

(6 citation statements)

References 19 publications

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“…In contrast, the predominance of normal and the presence of overweight or obesity observed in the more recent studies [4,6,7,17,19] changes the nutritional profile of this group. These findings are important and possibly results of improved health care for people with sickle cell disease and changes in diet for the world's population.…”

Section: Study Resultsmentioning

confidence: 75%

“…The studies applied varied the growth evaluation parameters. In addition, we observed the use of weight in 15 studies; of stature in 18 studies and of anthropometrics indicators in most studies (Height/age (H/A) in 17 Nogueira, et al 2015 Brazil [6] 357 HbSS and HbSC children/2 to 6 years (average: 3.7 years)/crosssectional and descriptive study.…”

Section: Study Resultsmentioning

confidence: 99%

“…Evaluation of growth used different reference standards, with the NCHS growth curve being the most used, since they were twenty-one studies prior to the publication of the 2006 and 2007 WHO growth curve. However, regardless of the standard used, the weight and height deficits were prevalent in children and adolescents with SCD [3][4][5][6][7]13,14,17,18,20,25,[27][28][29][30][31][32][33].…”

Section: Study Resultsmentioning

confidence: 99%

“…Micronutrient depletion contributes to the onset of low bone mineral density [11,12], of delays in skeletal maturation and growth deficit [15]. The importance of this monitor-ence mostly as of 2011's published studies [4][5][6][7].…”

Section: Study Resultsmentioning

confidence: 99%

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Nutritional Status of Children and Adolescents with Sickle Cell Disease

dos¹,

de²,

Ivo³

et al. 2018

J Nutri Med Diet Care

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Sickle cell disease (SCD) is a public health problem that interferes in the nutritional status of children and adolescents. Objective: To describe of the nutritional status and identify the factors associated with the growth deficit or obesity of children and adolescents with sickle cell disease. Methods: Critical analysis of originals articles published in Portuguese, English and Spanish in the electronic bases Medline, SciELO and LILACS with participants of 0 to 19 years old diagnosed with SCD. Results: We identified 37 articles that describe low weight, short stature and overweight or obesity prevalence ranging between 3 and 100%, 8.2% and 24.0%, 1.6% and 22.4%, respectively. The associated factors to the growth deficit were the increase of resting energy expenditure, the presence of low bone density, the high prevalence of low zinc and D-vitamin plasma concentration, the low consume of calcium and D-vitamin, vessel occlusion crises, increased need of transfusions and hormonal amendments presence. Conclusion: Amendments by weight and stature were frequent; however, we note an adjustment once the presence of overweight and obesity already exists in this group. The blood transfusion, the zinc supplementation and the regular use of hydroxyurea has shown benefit in the growth of children and adolescents with sickle cell disease.

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Section: Study Resultsmentioning

confidence: 75%

Section: Study Resultsmentioning

confidence: 99%

Section: Study Resultsmentioning

confidence: 99%

Section: Study Resultsmentioning

confidence: 99%

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Nutritional Status of Children and Adolescents with Sickle Cell Disease

dos¹,

de²,

Ivo³

et al. 2018

J Nutri Med Diet Care

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“…Some determinants are already well established, such as genetic, clinical and laboratory factors, while others, such as psycho-social and nutritional factors, have been less well studied. 2 , 3 , 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

Hemoglobin A2 values in sickle cell disease patients quantified by high performance liquid chromatography and the influence of alpha thalassemia

Fonseca

Amorim

Purificação

et al. 2015

Revista Brasileira de Hematologia e Hemoterapia

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BackgroundIn sickle cell disease, the quantification of Hb A2 is important for the differential diagnosis between sickle cell anemia (Hb SS) and Hb S/β0-thalassemia.ObjectiveTo determine Hb A2 levels as quantified by high performance liquid chromatography in patients with sickle cell anemia (Hb SS) and with the SC hemoglobinopathy, with or without concomitant alpha thalassemia.MethodsThis is a retrospective study of 242 children aged between two and six years with diagnoses of Hb SS or Hb SC. The hemoglobin was evaluated using high performance liquid chromatography and alpha thalassemia [3.7 kb deletion (−α3.7)] was detected by polymerase chain reaction. Patients were classified as homozygous (−α3.7/−α3.7), heterozygous (−α3.7/α), or homozygous wild-type. Analysis of variance was used to compare the mean Hb A2 values between the alpha thalassemia groups.ResultsThe mean (± standard deviation) Hb A2 concentrations in the Hb SS group (n = 135) was 3.68 ± 0.65%. The mean values for individuals with Hb SS and heterozygous (n = 28) or homozygous for alpha thalassemia (n = 3) were 3.98 ± 0.64% and 4.73 ± 0.25%, respectively. The mean Hb A2 of all the Hb SC patients (n = 107) was 4.01 ± 0.507 with 4.29 ± 0.41% and 4.91 ± 0.22% in individuals heterozygous (n = 23) and homozygous for alpha thalassemia (n = 7), respectively. All patients homozygous for alpha thalassemia had Hb A2 levels above 3.5%. However, Hb A2 values above 5.2% were seen in patients with Hb SS and Hb SC, independently of alpha thalassemia.ConclusionHb A2 levels are elevated in patients with Hb S or Hb C, and are directly influenced by the alpha thalassemia genotypes.

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Factors Associated with Growth Retardation in Children Suffering from Sickle Cell Anemia: First Report from Central Africa

Kazadi

Ngiyulu

Gini-Ehungu

et al. 2017

Anemia

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Background. The aim of this study was to investigate and determine the risk factors associated with poor growth among SCA children. Methods. A cross-sectional study was conducted in Kinshasa, the capital's country. The nutritional status was assessed using the Z scores of the anthropometric indices. Results. We gathered data on the 256 patients, 138 females (53.9%), who entered the study. The mean age at presentation was 8.4 ± 4.9 years of age. Underweight, stunting, and wasting were found, respectively, in 47.7%, 10.5%, and 50.3% of SCA children. A history of hand-foot syndrome, more than 3 blood transfusions, being less than 12 months of age when receiving the first transfusion, more than two severe sickle crises per year, a medical history of severe infections, and the presence of hepatomegaly were associated with poor growth. When comparing sickle cell patients under 12 years of age (n = 159) to a group of 296 age-matched children with normal Hb-AA, a significantly higher proportion of subjects with stunting and underweight were found among SCA. Conclusion. Nutritional status encountered in Congolese sickle cell children has been described for the first time in this study. A high prevalence of poor growth in SCA children was found in our study.

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Breastfeeding and the anthropometric profile of children with sickle cell anemia receiving follow-up in a newborn screening reference service

Cited by 4 publications

References 19 publications

Nutritional Status of Children and Adolescents with Sickle Cell Disease

Nutritional Status of Children and Adolescents with Sickle Cell Disease

Hemoglobin A2 values in sickle cell disease patients quantified by high performance liquid chromatography and the influence of alpha thalassemia

Factors Associated with Growth Retardation in Children Suffering from Sickle Cell Anemia: First Report from Central Africa

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