Nutritional Status of Children and Adolescents with Sickle Cell Disease

dos, Santos Samara Agda; de, Oliveira Cecilia Lacroix; Ivo, Cortez Paulo; Cople, Rodrigues Cláudia dos Santos

doi:10.23937/2572-3278.1510027

Cited by 2 publications

(4 citation statements)

References 30 publications

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“…The significantly altered BMI percentiles of SCD children compared with control is not unexpected, aside that patients with SCD have greater than average requirements for calories and micronutrients [26,27] impacting BMI percentiles. The elevated rate of red cell turnover, an important peculiarity of SCD, stimulates a state of hypermetabolism.…”

Section: Discussionmentioning

confidence: 86%

Sickle Cell Disease Complications and BMI Percentiles of Pediatric Patients

Alaka,

Iyanda

2024

AJMAH

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BMI percentile is a good index of nutritional status among pediatric patients. Yet there is a dearth of information about the relationship between this important anthropometric parameter and specific severity indices among pediatric patients. The study is designed to explore the possibility of such a relationship. Methods: Pediatric study participants were divided into test [HbSS, HbSC] and control [HbAA] groups. The questionnaire was administered to obtain information on age, gender, and clinical features of the disease [pain frequency, leg ulcer, priapism]. The anthropometry indices were determined. BMI as well as BMI percentiles were calculated. Data were summarized using relative frequency, mean, and standard deviation while analysis of variance, LSD post hoc tests and Chi‑squared tests were used for inferential statistics. Significant levels were set with P < 0.05. Results: There were significant differences in the body weight, height and BMI of HbAA, HbSC and HbSS. The distribution of the BMI percentiles for the three genotypes showed that 5% of HbAA, 20% of HbSC, and 35.7% of HbSS were in unhealthy categories. The occurrence of leg ulcers and priapism among the two SCD genotypes was 0% and 3.57% respectively. The Chi-square tests showed a significant difference between BMI percentiles (X2=72.51; P=<.001) or painful episodes (X2=15.992; P=.003) and hemoglobin genotypes [HbSS, HbSC]. Among SCD patients there was a relationship between BMI percentiles and pain frequency (X2=50.59; P=<.001). Conclusion: The study suggests that SCD impacts BMI percentiles. Also, the frequency of occurrence of priapism and leg ulcers varied widely, indicating that priapism among the SCD patients may be a more common SCD complication than leg ulcer in the region. The fact that there was a higher frequency of pain among HbSS than HbSC suggests a bias in distribution of pain frequency in the 2 hemoglobinopathies.

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Section: Discussionmentioning

confidence: 86%

Sickle Cell Disease Complications and BMI Percentiles of Pediatric Patients

Alaka,

Iyanda

2024

AJMAH

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“…Stunted growth and delayed sexual maturation are common consequences, affecting the long-term health and quality of life of these individuals. [54] Nutrient deficiencies, especially in essential vitamins and minerals, can weaken the immune system. Weakened immunity makes individuals with SCA more susceptible to infections, including bacterial and viral infections, which can further complicate their health and lead to frequent hospitalizations.…”

Section: Impact Of Malnutrition On Scamentioning

confidence: 99%

“…Stunted growth and delayed sexual maturation are common consequences, affecting the long-term health and quality of life of these individuals. [ 54 ]…”

Section: Impact Of Malnutrition On Scamentioning

confidence: 99%

“…Weakened immunity makes individuals with SCA more susceptible to infections, including bacterial and viral infections, which can further complicate their health and lead to frequent hospitalizations. [ 54 ] Malnutrition can lead to neurological complications, particularly in the case of vitamin B12 and folic acid deficiencies. Cognitive impairment and peripheral neuropathy are potential consequences that can impact cognitive function and overall quality of life.…”

Section: Impact Of Malnutrition On Scamentioning

confidence: 99%

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Malnutrition in sickle cell anemia: Prevalence, impact, and interventions: A Review

Obeagu,

Obeagu

2024

Medicine

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Sickle Cell Anemia (SCA) is a hereditary hemoglobinopathy characterized by chronic hemolytic anemia, vaso-occlusive events, and a wide range of clinical complications. Malnutrition, often an underexplored aspect of this complex condition, plays a critical role in disease management and overall patient well-being. This publication provides a comprehensive review of the prevalence, impact, and interventions related to malnutrition in individuals with SCA. A thorough literature review reveals the multifaceted challenges faced by SCA patients in maintaining adequate nutrition. The pathophysiology of SCA, involving chronic inflammation, oxidative stress, and hypermetabolism, contributes to increased nutritional requirements and altered dietary patterns. Factors such as reduced appetite, nutrient malabsorption, dietary restrictions, and socioeconomic disparities further exacerbate the risk of malnutrition. Malnutrition is a prevalent issue among individuals with SCA, affecting patients of different age groups and disease severities. Nutritional deficiencies, including vitamins, minerals, and essential nutrients, are common in this population. The impact of malnutrition on disease outcomes is significant, with associations between nutrient status and complications such as pain crises, infections, and impaired quality of life. This paper also reviews nutritional interventions aimed at addressing malnutrition in SCA patients. While dietary counseling, supplementation, and personalized nutrition plans have shown promise in improving nutritional status, challenges such as patient adherence and access to healthcare must be addressed to optimize their effectiveness.

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Nutritional Status of Children and Adolescents with Sickle Cell Disease

Cited by 2 publications

References 30 publications

Sickle Cell Disease Complications and BMI Percentiles of Pediatric Patients

Sickle Cell Disease Complications and BMI Percentiles of Pediatric Patients

Malnutrition in sickle cell anemia: Prevalence, impact, and interventions: A Review

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