Breastfeeding after maternal immunisation during pregnancy: Providing immunological protection to the newborn: A review

Maertens, Kirsten; Schutter, Sara De; Braeckman, Tessa; Baerts, Lesley; Damme, Pierre Van; Meester, Ingrid De; Leuridan, Elke

doi:10.1016/j.vaccine.2014.01.083

Cited by 78 publications

(63 citation statements)

References 29 publications

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“…a-lactalbumin and LTF (an iron-binding immunomodulatory protein with antibacterial properties), which are the most nutritionally important, caseins, and Igs (IgA for up to 10% of human milk protein, IgM and IgG). Igs provide passive immunity to the newborn and also serve as part of the immune system of the MG [71].…”

Section: Milk Compositionmentioning

confidence: 99%

Physiology of milk secretion

Truchet

Honvo-Houeto

2017

Best Practice & Research Clinical Endocrinology & Metab

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Section: Milk Compositionmentioning

confidence: 99%

Physiology of milk secretion

Truchet

Honvo-Houeto

2017

Best Practice & Research Clinical Endocrinology & Metab

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“…TT and PPS are two vaccines frequently administered during pregnancy to induce protection in women and newborns 4 . During intrauterine development, the fetus receives protection by transplacental transfer of immunoglobulin (Ig)G antibodies and, after birth, by maternal lactation containing mainly secretory IgA.…”

Section: Introductionmentioning

confidence: 99%

“…During intrauterine development, the fetus receives protection by transplacental transfer of immunoglobulin (Ig)G antibodies and, after birth, by maternal lactation containing mainly secretory IgA. Thus, antigen-specific Igs can be measured in serum and secretions such as colostrum and breast milk 4 .…”

Section: Introductionmentioning

confidence: 99%

Antigenic Stimulation During Pregnancy Modifies Specific IgA1 and IgA2 Subclasses in Human Colostrum According to the Chemical Composition of the Antigen

Sánchez‐Salguero¹,

Rodríguez-Chacón²,

Leyva-Daniel³

et al. 2020

RIC

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Background: Several studies have evaluated the effect of infectious diseases and vaccine protocols during pregnancy on maternal milk immunoglobulin (Ig) levels, to understand the protection conferred by lactation on newborns. Colostrum is the primary source of maternal IgA for the newborn. IgA participates in protection mechanisms in the neonate's mucosa. In humans, IgA has two subclasses with differential anatomical distribution among mucosal compartments. Total IgA levels in maternal milk vary after antigen stimulation and have differential affinities in function of the chemical composition of the antigens. We studied the effect of antigenic stimulation during pregnancy on the concentrations of specific IgA1 and IgA2 subclasses in human colostrum. Methods: We analyzed data from 113 women in Mexico City and compared the amount of IgA subclasses in colostrum against three antigens: two from vaccine protocols (tetanus toxoid and pneumococcal polysaccharides) and lipopolysaccharide, a ubiquitous antigen in the gastrointestinal tract. Results: In agreement with the previous reports, we showed that IgA1 from colostrum mainly recognized protein antigens; in sharp contrast, IgA2 was mostly directed against polysaccharide antigens. These levels increased in women who had previous contacts through vaccination or infections during pregnancy. Conclusions: Antigen interaction during pregnancy increased the amount of specific IgA subclasses, depending on the chemical composition of the antigen.

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“…Breastfeeding after maternal immunisation during pregnancy has been shown to promote transplacental IgG transfer and after birth, IgA is found in breastmilk. Both mechanisms provide immunological protection to the newborn [84,85]. Some protection from antibodies in breastmilk lasts as long as breastfeeding is continued, but as the infants' digestive systems develop, denaturation of some antibodies may occur.…”

Section: Maternal Vaccinationmentioning

confidence: 99%

Breastfeeding and the Risk of Infant Illness in Asia: A Review

Lee

Binns

2019

IJERPH

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Infancy remains the most vulnerable period of human life for death, illness, and establishing a lifetime trajectory of growth and health. It is estimated that there are 5.3 million deaths under five years of age worldwide and approximately 800,000 lives could be saved by improving breastfeeding rates and duration. In Asia, an estimated 300,000–350,000 child deaths could be prevented with optimal breastfeeding and the majority would be under 12 months of age. We present a systematic review of studies of infection and breastfeeding in infants in Asia and further review interactions of selected infectious diseases and breastfeeding. Initially, 2459 records of possible interest were identified, 153 full text papers were reviewed in detail, and 13 papers describing diarrhoeal disease and/or acute respiratory tract infection were selected for inclusion in the review. Additional papers were selected to discuss specific diseases and their relationship to breastfeeding. The review found that a variety of methods were used with differing definitions of breastfeeding and diseases. Overall, breastfeeding when compared to the use of infant formula, is associated with significantly lower rates of diarrhoeal disease and lower respiratory tract infection, with a reduction of 50% or more to be expected, especially in infants under six months of age. The relationship between breastfeeding and specific diseases including measles and HTLV1 were reviewed. Breastfeeding reduces some disease rates, but there remain a few conditions where breastfeeding may be contra-indicated.

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Breastfeeding after maternal immunisation during pregnancy: Providing immunological protection to the newborn: A review

Cited by 78 publications

References 29 publications

Physiology of milk secretion

Physiology of milk secretion

Antigenic Stimulation During Pregnancy Modifies Specific IgA1 and IgA2 Subclasses in Human Colostrum According to the Chemical Composition of the Antigen

Breastfeeding and the Risk of Infant Illness in Asia: A Review

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