Breast Sentinel Lymph Node Mapping at CT Lymphography with Iopamidol: Preliminary Experience

Suga, Kazuyoshi; Yuan, Yue; Okada, Munemasa; Matsunaga, Naofumi; Tangoku, Akira; Yamamoto, Shigeru; Oka, M.

doi:10.1148/radiol.2302021380

Cited by 66 publications

(49 citation statements)

References 31 publications

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“…More intelligent targeting of the SLN is clearly required, and experimental work using radionuclide isotope [21] or US contrast agents [22] to aid identification of the SLN shows promise. Suga et al have shown that injecting intra-parenchymal contrast can delineate sentinel nodes on computed tomography [23]. However, if biopsy of morphologically normal nodes is unrewarding at present, what criteria should the radiologist use to identify and biopsy the nodes?…”

Section: Discussionmentioning

confidence: 99%

Use of ultrasound-guided axillary node core biopsy in staging of early breast cancer

et al. 2008

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The aim of this study was to see how effective ultrasound-guided needle biopsy was at detecting lymph node involvement in patients with early breast cancer. Patients with newly diagnosed invasive breast cancer underwent axillary ultrasound (US) where lymph node size and morphology were noted. A core biopsy (CB) was undertaken of any node greater than 5 mm in longitudinal section. Patients with benign CBs proceeded to sentinel lymph node (SLN) biopsy, whereas those with malignancy underwent axillary lymph node dissection (ALND). US and CB findings were correlated with final surgical histology in all cases. One hundred and thirty-nine patients were examined, of whom 52.5% had lymph node metastases on final histology. One hundred and twenty-one patients (87%) underwent axillary node CB. The overall sensitivity of CB for detecting lymph node metastases was 53.4% (60.3% for macrometastases; 26.7% for micrometastases). The US morphological characteristics most strongly associated with malignancy were absence of a hilum and a cortical thickness greater than 4 mm. However, one third of patients with normal lymph node morphology had nodal metastases, and only 12% of these were diagnosed on CB. CB of axillary lymph nodes can diagnose a substantial number of patients with lymph node metastases, allowing these patients to proceed directly to ALND, avoiding unnecessary SLN biopsy.

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Section: Discussionmentioning

confidence: 99%

Use of ultrasound-guided axillary node core biopsy in staging of early breast cancer

et al. 2008

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“…Level 1 consists of nodes below the lateral border of the muscle, level 2 consists of nodes behind the muscle, and level 3 consists of nodes above the medial border of the muscle. Most sentinel lymph nodes are level 1 nodes located in the inferior distribution of axillary nodes (1,19). In our experience over the past 3 years, abnormal lymph nodes are often seen in the tissues near the axillary tail, where core needle biopsy can be performed safely and easily.…”

Section: Anatomymentioning

confidence: 93%

US-guided Core Needle Biopsy of Axillary Lymph Nodes in Patients with Breast Cancer: Why and How to Do It

et al. 2007

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“…[1][2][3][4][5][6][7][8][9][10] Contrast-enhanced sonography can survey only to a limited depth from the detector, and so, it is not suitable for detecting the deep lymphatic system. CT lymphography using water-soluble, nanoparticulate, iodine contrast, oil-in-water emulsion has been reported as a feasible method to detect lymph nodes with high resolution images.…”

Section: Introductionmentioning

confidence: 99%

Interstitial MR Lymphography in Mice: Comparative Study with Gadofluorine 8, Gadofluorine M, and Gadofluorine P

et al. 2012

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Purpose: We investigated the characteristics and capability of interstitial MR lymphography in mice using gado‰uorine 8, gado‰uorine M, and gado‰uorine P.Methods: We injected healthy mice with 0.5 mmol of Gd gado‰uorine 8, gado‰uorine M, or gado‰uorine P subcutaneously into the right rear footpad and assessed the time courses of contrast enhancement in the lymph nodes. Six mice were studied for each contrast agent. We also used gado‰uorine M to assess the lymphatic pathway from the right and left rear feet or tail.Results: Contrast enhancement was demonstrated for the right popliteal, sacral, and iliac lymph nodes in all mice 5 minutes after injection of each of the 3 agents and decreased gradually. Enhancement in the lymph nodes was still detectable 30 minutes after injection of gado‰uorine 8 or gado‰uorine M. Enhancement became obscure sooner after gado‰uo-rine P injection and was mildly stronger with the other 2 contrast agents. Clear diŠerences were found in the hepatobiliary and urinary kinetics of the 3 agents. Gado‰uorine M injected into various sites delineated the lymphatic pathway from the site of injection.Conclusion: Interstitial MR lymphography using gado‰uorine 8, gado‰uorine M, and gado‰uorine P oŠered clear visualization of the lymphatic pathway in healthy mice during a su‹cient imaging time window, and allowed repeated assessment of the pathway and clariˆcation of the lymphatic system.

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Breast Sentinel Lymph Node Mapping at CT Lymphography with Iopamidol: Preliminary Experience

Abstract: Because preoperative CT lymphography-guided SLN mapping provides SLN position with detailed lymphatic anatomy, it may be useful for the direction of breast SLN biopsy.

Cited by 66 publications

References 31 publications

Use of ultrasound-guided axillary node core biopsy in staging of early breast cancer

Use of ultrasound-guided axillary node core biopsy in staging of early breast cancer

US-guided Core Needle Biopsy of Axillary Lymph Nodes in Patients with Breast Cancer: Why and How to Do It

Interstitial MR Lymphography in Mice: Comparative Study with Gadofluorine 8, Gadofluorine M, and Gadofluorine P

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