Breast reconstruction de novo by water-jet assisted autologous fat grafting – a retrospective study

Hoppe, Delia Letizia; Ueberreiter, Klaus; Surlemont, Y.; Peltoniemi, Hilkka; Stabile, Marco; Kauhanen, Susanna

doi:10.3205/000185

Cited by 20 publications

(9 citation statements)

References 68 publications

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“…Based on either the LENT-SOMA scale assessment [ 27 ] or satisfaction assessment questionnaire [ 28 , 29 , 32 , 33 ], most available patients [ 27 – 29 , 32 , 33 ] and investigators [ 27 ] were satisfied with the treatment results. There were no serious adverse events associated with the CAL procedure, such as disease transmission or septicaemia resulting from bacterial contamination [ 36 – 38 ]. Fat necrosis was reported to be the most common complication in the three studies of Tissiani et al, Gentile et al, and Jeon et al; neither the incidence rates between the CAL group and the lipofilling group were significantly different ( P > 0.05) [ 28 , 32 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

Current perspectives on cell-assisted lipotransfer for breast cancer patients after radiotherapy

Chen

Peng

et al. 2023

World J Surg Onc

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Background Cell-assisted lipotransfer (CAL), a technique of autologous adipose transplantation enriched with adipose-derived stem cells (ADSCs), has the potential to improve cosmetic outcomes at irradiated sites. However, many concerns have been raised about the possibility of ADSCs increasing oncological risk in cancer patients. With the increasing demand for CAL reconstruction, there is an urgent need to determine whether CAL treatment could compromise oncological safety after radiotherapy, as well as to evaluate its efficacy in guiding clinical decisions. Methods A PRISMA-compliant systematic review of the safety and efficacy of CAL in breast cancer patients after radiotherapy was conducted. The PubMed, Ovid, Cochrane Library, and ClinicalTrials.gov databases were comprehensively searched from inception to 31 December 2021. Results The search initially yielded 1185 unique studies. Ultimately, seven studies were eligible. Based on the limited outcome evidence, CAL did not increase recurrence risk in breast cancer patients but presented aesthetic improvement and higher volumetric persistence in a long-term follow-up. Although breast reconstruction with CAL also had oncological safety after radiotherapy, these patients needed more adipose tissue and had relatively lower fat graft retention than the non-irradiated patients (P < 0.05). Conclusions CAL has oncological safety and does not increase recurrence risk in irradiated patients. Since CAL doubles the amount of adipose required without significantly improving volumetric persistence, clinical decisions for irradiated patients should be made more cautiously to account for the potential costs and aesthetic outcomes. There is limited evidence at present; thus, higher-quality, evidence-based studies are required to establish a consensus on breast reconstruction with CAL after radiotherapy.

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Section: Resultsmentioning

confidence: 99%

Current perspectives on cell-assisted lipotransfer for breast cancer patients after radiotherapy

Chen

Peng

et al. 2023

World J Surg Onc

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“…However, there is ample evidence that supports the safety and effectiveness of fat grafting of the breast in terms of breast cancer detection and surveillance. [55][56][57][58][59][60][61][62][63][64] The majority of the panelists (75%) stated that fat grafting represents a safe procedure when considering the impact on breast cancer detection and surveillance if a proper technique for grafting is used and the follow-up is granted by dedicated breast imaging specialists. Twentyfive percent of the panelists consider fat grafting safe in terms of breast cancer detection and surveillance, with the need of informing the patient about the possibility of higher second level examination rates (magnetic resonance imaging/biopsies).…”

Section: Discussionmentioning

confidence: 99%

International Expert Panel Consensus on Fat Grafting of the Breast

Nava

Blondeel

Botti³

et al. 2019

Plastic and Reconstructive Surgery - Global Open

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“…Understandably, the main focus was on general medical complications, such as bleeding or embolism, rather than aesthetic side effects. Remarkably, besides contour irregularities reported in five of the 21 articles 26,27,30,35,14 , no other unfavourable aesthetic outcomes were mentioned. In addition, other adverse events such as sensory disorders were not mentioned.…”

Section: Summary Of Main Resultsmentioning

confidence: 86%

Donor site complications and satisfaction in autologous fat grafting for breast reconstruction: A systematic review

Wederfoort

Hebels

Heuts

et al. 2022

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Breast reconstruction de novo by water-jet assisted autologous fat grafting – a retrospective study

Cited by 20 publications

References 68 publications

Current perspectives on cell-assisted lipotransfer for breast cancer patients after radiotherapy

Current perspectives on cell-assisted lipotransfer for breast cancer patients after radiotherapy

International Expert Panel Consensus on Fat Grafting of the Breast

Donor site complications and satisfaction in autologous fat grafting for breast reconstruction: A systematic review

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