Breast-milk levels of polybrominated diphenyl ether flame retardants in relation to women's age and pre-pregnant body mass index

Koh, Teck-Wai; Chen, Solomon Chih–Cheng; Chang-Chien, Gou-Ping; Lin, Ding-Yan; Chen, Fu‐An; Chao, How‐Ran

doi:10.1016/j.ijheh.2009.09.004

Cited by 32 publications

(14 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increase in PBDE levels has been also observed in human samples in Japan, Norway, and North America (Akutsu et al, 2003;Sjödin et al, 2004;Thomsen et al, 2002). However, studies pointed out that the PBDE levels in serum seemed to have stabilized from 1999 to 2003 (Thomsen et al, 2007), and PBDE levels in breast milk were significantly lower in 2007 and 2008 than those in 2000 and 2001 (Chao et al, 2007;Koh et al, 2010), although some studies did not observe the decreases (Shy et al, 2012). The decreases of PBDE levels were probably due to the decreasing amounts of PBDEs released into the environment.…”

Section: Temporal Trends Of Pbdes In Breast Milk During 2006-2012mentioning

confidence: 95%

Polybrominated biphenyl ethers in breast milk and infant formula from Shanghai, China: Temporal trends, daily intake, and risk assessment

Zhang

Yang

et al. 2014

Science of The Total Environment

View full text Add to dashboard Cite

Section: Temporal Trends Of Pbdes In Breast Milk During 2006-2012mentioning

confidence: 95%

Polybrominated biphenyl ethers in breast milk and infant formula from Shanghai, China: Temporal trends, daily intake, and risk assessment

Zhang

Yang

et al. 2014

Science of The Total Environment

View full text Add to dashboard Cite

“…The analytical methods used to examine breast milk PBDE levels are described in our previous studies (5,21,22). Briefly, milk samples with internal standards ( 13 C 12 -labeled BDE-28, 47, 99, 153, 183, 197, 207, and 209) were extracted by sonication and then were centrifuged.…”

Section: Methodsmentioning

confidence: 99%

Levels of Breast Milk PBDEs From Southern Taiwan and Their Potential Impact on Neurodevelopment

et al. 2011

Self Cite

View full text Add to dashboard Cite

ABSTRACT:In vivo studies have demonstrated that prenatal or neonatal exposure to polybrominated diphenyl ethers (PBDEs) causes developmental neurotoxicity. However, there is a lack of human data. Our hypothesis was that PBDEs would result in lower infant neurodevelopment scores. This is a post hoc analysis of previous studies. Fourteen PBDEs in 70 breast milk were analyzed using a high-resolution gas chromatograph/high-resolution mass spectrometer. Infant neurodevelopment at the age of 8 -12 mo was determined using the Bayley Scales of Infants and Toddlers Development, third edition (Bayley-III). The median of ⌺ 14 PBDEs (the sum of 14 PBDE congeners) was 2.92 ng/g lipid. The ⌺ 14 PBDE concentrations were not correlated with Bayley-III scores on cognitive, language, motor, social-emotional, or adaptive behavior scales. A significantly inverse association between brominated diphenyl ether (BDE)-209 and the cognitive scale was found after multivariate stepwise linear regression analyses (B ϭ Ϫ0.007, adjusted R ϭ Ϫ0.224, p ϭ 0.032). In contrast, the language scale was positively correlated with BDE-196 (B ϭ 0.096, adjusted R ϭ 0.315, p ϭ 0.002). Our results are consistent with most in vivo studies, suggesting that prenatal or postnatal exposure to BDE-209 potentially delays the neurological development. (Pediatr Res 70: 596-600, 2011) P olybrominated diphenyl ethers (PBDEs), which are only used as brominated flame retardants, are widely found in a variety of commercial and household products including foam furniture padding, plastics, electrical equipment, paints, textiles, construction materials, and vehicles (1). PBDEs are similar in structure to polychlorinated biphenyls; but in contrast to point sources of polychlorinated biphenyl contamination, PBDEs are widespread and released into the environment from more sources (2).A marked period of rapid brain growth and development begins in humans during the third trimester of pregnancy and continues throughout the first 2 y of life. PBDE congeners are considered to be neurotoxicants, although more work needs to be done to determine whether in utero and postnatal exposure to PBDEs has any adverse effects on human neurodevelopment, and the effects of PBDEs on human health remain unclear (3). However, recent studies have shown that human exposure to PBDEs causes a reduction in women's fecundability (4), a prolongation of menstruation periods (5), an increase in serum LH in male infants (6), and disruption of thyroxine (T4), triiodothyronine (T3) and thyroid-stimulating hormones in male adults (7), and a positive association with diabetes prevalence (8).Postnatal infant exposure to PBDEs mainly comes from breast milk and house dust (9); moreover, PBDE levels in infants and children are higher than those in adults (10). Recently, epidemiological studies of in utero exposure to PBDEs have found it to be associated with the physiological and neurological development of infants and children (6,(11)(12)(13)(14)(15)(16). In addition, lower birth weights were correlated with hi...

show abstract

“…The animal studies showed that PBDEs disrupted thyroid function and spermatogenesis (Bowers et al, 2015;Huang et al, 2015), impaired mitochondrial function (Huang et al, 2015), induced hepatotoxicity (Ćurčić et al, 2015), caused developmental abnormalities (Berger et al, 2014), affects neurological behaviour (Costa and Giordano, 2011). They tend to accumulate in human bodies and have been detected in human milk and umbilical cord blood (Wang et al, 2008;Lin et al, 2011;Koh et al, 2010). Human with prenatal or postnatal exposure to PBDEs has been demonstrated to be associated with several adverse health outcomes (Chao et al, 2014b;Hsu et al, 2014) including low birth length and weight (Chao et al, 2007), menstrual irregularity , disruption of thyroid and growth hormones (Shy et al, 2012), and interference with neurological development in infants (Chao et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Levels of Polybrominated Diphenyl Ethers in Air-Conditioner Filter Dust Used to Assess Health Risks in Clinic and Electronic Plant Employees

Chou

Kao

Chuang

et al. 2016

Aerosol Air Qual. Res.

Self Cite

View full text Add to dashboard Cite

Because consumer products release them, polybrominated diphenyl ethers (PBDEs) are frequently present in a variety of indoor environments including homes and workplaces. Our goal was to investigate PBDEs contamination of workplace air-conditioner filter dust to assess the health effects of contaminated dust on workers with occupational exposure. Nine medical clinics, four dental clinics, eight factory offices, and six factory clean rooms were selected in southern Taiwan between April 2013 and September 2014. Air-conditioner-filter dust was collected by a high-efficiency vacuum cleaner and then PBDEs were analyzed by a high-resolution gas chromatography coupled with high-resolution mass spectrometry.

show abstract

Breast-milk levels of polybrominated diphenyl ether flame retardants in relation to women's age and pre-pregnant body mass index

Cited by 32 publications

References 46 publications

Polybrominated biphenyl ethers in breast milk and infant formula from Shanghai, China: Temporal trends, daily intake, and risk assessment

Polybrominated biphenyl ethers in breast milk and infant formula from Shanghai, China: Temporal trends, daily intake, and risk assessment

Levels of Breast Milk PBDEs From Southern Taiwan and Their Potential Impact on Neurodevelopment

Levels of Polybrominated Diphenyl Ethers in Air-Conditioner Filter Dust Used to Assess Health Risks in Clinic and Electronic Plant Employees

Contact Info

Product

Resources

About