Breast milk fatty acids and allergic disease in preschool children: The Prevention and Incidence of Asthma and Mite Allergy birth cohort study

Wijga, Alet H.; Houwelingen, A.C. van; Kerkhof, Marjan; Tabak, Cora; Jongste, Johan C. de; Gerritsen, Jorrit; Boshuizen, Hendriek C.; Brunekreef, Bert; Smit, Henriëtte A.

doi:10.1016/j.jaci.2005.10.022

Cited by 97 publications

(104 citation statements)

References 25 publications

(30 reference statements)

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“…Kandungan sIgA, TGF-β2 dan asam lemak tidak jenuh rantai ganda dalam ASI ibu dengan atopi lebih rendah dibandingkan ibu tanpa riwayat atopi. 35,[53][54][55][56] Adanya kontroversi antara studi yang satu dengan lainnya disebabkan juga adanya perbedaan desain penelitian, perbedaan kriteria diagnosis DA, randomisasi, dan blinding. 42 Keterbatasan studi kami adalah adanya kemungkinan bias recall dan bias pemilihan subjek.…”

Section: Pembahasanunclassified

Manfaat Pemberian ASI Eksklusif dalam Pencegahan Kejadian Dermatitis Atopi pada Anak

Halim

Munasir

Rohsiswatmo

2016

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D ermatitis atopi (DA) adalah kelainan inflamasi kronis pada kulit yang sering terjadi pada anak. Masalah ini menjadi semakin penting karena prevalens yang meningkat di seluruh dunia.1-5 Prevalens DA pada anak meningkat 2-3 kali selama tiga dekade terakhir terutama di negara maju, seperti di Amerika Serikat, Jepang, dan negara-negara di Eropa Barat (10%-20%).3-9 Prevalens DA yang lebih rendah terdapat pada negara berkembang di Eropa Timur, Afrika, dan Asia Tengah.3,5,10 Sebuah studi kohort di Jakarta pada tahun 2010 dilaporkan prevalens DA 16,4% pada anak berusia 0-6 bulan. 11Sekitar 80% anak dengan DA akan mengalami asma dan rinitis alergi (allergic march) di kemudian hari.

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Section: Pembahasanunclassified

Manfaat Pemberian ASI Eksklusif dalam Pencegahan Kejadian Dermatitis Atopi pada Anak

Halim

Munasir

Rohsiswatmo

2016

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“…Breastfeeding has been considered to afford protection against atopic disorders. Protection may be conveyed by biologically active molecules that are present in human milk such as cytokines, chemokines, hormones, growth factors, secretory antibodies and essential fatty acids [2,3]. Through several mechanisms, immune-modulating factors in human milk can actively stimulate the newborn's immune system, which is rapidly maturing during the first years of life [4].…”

Section: Introductionmentioning

confidence: 99%

Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study)

Snijders

Damoiseaux²,

Penders

et al. 2006

Clin Experimental Allergy

113

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SummaryBackground Conflicting evidence exists concerning the protective role of breastfeeding in allergy and atopic disease aetiology. Breast milk contains biologically active molecules influencing the innate immune system of newborns. Objective We aim to assess whether cytokines (TGF-b1, IL-10 and IL-12) and soluble CD14 (sCD14) in breast milk are influenced by maternal atopic constitution and modify the development of atopic manifestations in infants. Methods Milk samples were collected at 1 month post-partum of 315 lactating mothers participating in the ongoing KOALA Birth Cohort Study. The cytokines and sCD14 were analysed by ELISA in the aqueous fraction. We compared the concentrations of cytokines and sCD14 in breast milk between mothers with and without an allergic history and also with and without allergic sensitization (specific IgE). Associations of cytokines and sCD14 with the development of eczema, wheezing in the first 2 years of life and allergic sensitization of infants at the age of 2 years were analysed by multivariate logistic regression analyses to correct for confounders. Results We found higher sCD14 levels in mothers with a positive vs. negative allergic history (7.6 vs. 7.0 mg/mL; P = 0.04) and in mothers who were sensitized vs. non-sensitized (7.8 vs. 7.1 mg/mL; P = 0.03). None of the studied immune factors were associated with infant's atopic outcomes. IL-10 was not detected above the detection limit of 0.2 pg/mL. Conclusion Taking together the results of the present and previous studies, we conclude that there is no convincing evidence for a relation between TGF-b1, sCD14, IL-10 or IL-12 in breast milk and atopic manifestations in infants.

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“…However, we should note that both of these studies [15,16] are controversial and remain to be replicated. There also appears to be an inverse relationship between the content of n-3 long chain polyunsaturated fatty acids in breast milk and the development of allergic symptoms, although no such effect was found on sensitization rate [17].…”

Section: Handwashingmentioning

confidence: 94%

Treatment of Eczema

Chang

Keen

Gershwin

2007

Clinic Rev Allerg Immunol

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Eczema is a chronic inflammatory skin disease that has reached nearly epidemic proportions in childhood. Moreover, it is a difficult disease to control and, with its onset in childhood, is often the first manifestation of atopy. The clinical features of eczema include itchy red skin accompanied by dryness and lichenification. In the past, treatment options consisted primarily of avoidance of soap and water. These options have considerably improved with both nonpharmacologic and pharmacologic approaches. However, eczema is still a treatment challenge. Part of the problem in developing new treatment options has been the relative failure in translating basic science information into clinical application. It is hoped that the newer biologics will help bridge this gap and lead to greater success rates.

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Breast milk fatty acids and allergic disease in preschool children: The Prevention and Incidence of Asthma and Mite Allergy birth cohort study

Abstract: In susceptible infants, the risk to develop allergic symptoms, but not the risk of sensitization, was modified by intake of n-3 long chain polyunsaturated fatty acids through breast milk.

Cited by 97 publications

References 25 publications

Manfaat Pemberian ASI Eksklusif dalam Pencegahan Kejadian Dermatitis Atopi pada Anak

Manfaat Pemberian ASI Eksklusif dalam Pencegahan Kejadian Dermatitis Atopi pada Anak

Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study)

Treatment of Eczema

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