Breast metastasis of primary colon cancer

Bobadilla, L. Fernández de; Villanueva, Augusto; Collado, M. A. Garrido; Juan, Amparo; Rojo, Roberto; Pérez, Judith; Lisa, Eduardo; Aguilera, A.; Mena, Antonio; González-Palacios, Fernando

doi:10.4321/s1130-01082004000600007

Cited by 20 publications

(24 citation statements)

References 8 publications

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“…[2][3][4] However, our patient has no sign of further metastases even after 1.5 years of follow up. This suggests that a metastatic tumor to the breast from colon adenocarcinoma is unlikely, and supports the possibility of a double malignant seeding implantation after the lung metastasis resection.…”

Section: Discussionmentioning

confidence: 96%

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Metastatic seeding of colon adenocarcinoma manifesting as synchronous breast and chest wall localization: Report of a case

et al. 2011

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Colon carcinoma rarely metastasizes to the breast and it is usually associated with a poor prognosis. Even rarer is metastatic seeding of colon cancer cells in an intramammary location after surgery. Including a primary breast malignancy in the differential diagnosis of such cases is mandatory. We report a rare case of double seeding implantation of colon adenocarcinoma inside the breast parenchyma and intercostal muscles 6 years after resection of a pulmonary metastasis from colon adenocarcinoma. The metastasis was revealed by the presence of bone metaplasia in the intercostal muscles. We discuss how negative immunostaining for estrogen receptors, progesterone receptors, and HER-2, along with the immunohistochemical pattern of cytokeratin (CK) 20+/7-/5- and CDX2-positive immunostaining, excludes a primary breast malignancy, namely, a "matrix-producing" carcinoma, from the differential diagnosis. We also present the hypothesis of a paracrine pathogenetic mechanism to explain the bone metaplasia.

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Section: Discussionmentioning

confidence: 96%

“…Breast metastases from colon adenocarcinoma are very rare [1][2][3][4] and may be confused with a primary neoplasm of the breast. Because the treatment and outcome of primary and secondary malignancies of the breast are completely different, an accurate diagnosis is important.…”

Section: Introductionmentioning

confidence: 99%

Metastatic seeding of colon adenocarcinoma manifesting as synchronous breast and chest wall localization: Report of a case

et al. 2011

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“…According to the literature, metastatic malignances in breast are more common in the left breast compared with the right (12). These metastases usually grow rapidly, but do not induce skin dimpling, nipple retraction or nipple discharge (13,14).…”

Section: Discussionmentioning

confidence: 99%

Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report

et al. 2017

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Breast cancer has the highest rate of incidence among all types of cancer in women. Only ~0.43% of breast malignancies occur as a result of metastatic lesions from extramammary tumors. The present study reports an extremely rare case of transverse colon cancer metastasizing to the bilateral ovaries and the left breast. The patient was a 47-year old female, who had a lump in the left breast without axillary lymphadenopathy. Specimens obtained by core needle biopsy were submitted for hematoxylin and eosin examination, and results revealed that the lump was a poorly differentiated adenocarcinoma. Since the patient had elevated levels of the carcinoembryonic antigen and a medical history of a Krukenberg tumor metastasized from colon cancer, immunohistochemical examinations were applied. Results identified that caudal-related homeobox protein 2 and cytokeratin 20 were positively stained, whilst cytokeratin 7 was negatively stained. Therefore, this patient was diagnosed as having colon cancer that had metastasized to the bilateral ovaries and the left breast. As the life expectancy of patients with cancer is increasing, types of metastases that used to be seen as rare are increasingly becoming more common. For clinicians, diagnosis should be cautious, and differential diagnosis should always be kept in mind.

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“…The latest review in 2004 identified 8 cases [1]. Searching Medline, including the nonEnglish literature, and hand-searching the references, we identified a further 11 cases including our own (table 1).…”

Section: Discussionmentioning

confidence: 99%

Metastasis of Primary Colon Cancer to the Breast – Leave Well Alone

Barthelmes

Simpson²,

Douglas-Jones³

et al. 2010

Breast Care

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Background: Metastasis to the breast is rare. Its management differs from that of primary breast cancer, as illustrated by this case of a colonic metastasis to the breast. Case Report: A 78-year-old woman presented with a breast lump 16 months after a palliative colonic resection for an obstructing colon cancer (T4 N0 M1). Core biopsy of the breast lump revealed morphological features identical to the original bowel cancer. In view of her progressive metastatic disease, the breast lump was simply observed. She passed away 4 months later from advanced intra-abdominal carcinomatosis. Discussion: There are 19 cases of colonic metastasis to the breast in the literature. In the literature, colonic metastases to the breast are usually excised. Conclusion: Excision of a colonic metastasis to the breast can be avoided if the patient’s life expectancy is short.

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Breast metastasis of primary colon cancer

Cited by 20 publications

References 8 publications

Metastatic seeding of colon adenocarcinoma manifesting as synchronous breast and chest wall localization: Report of a case

Metastatic seeding of colon adenocarcinoma manifesting as synchronous breast and chest wall localization: Report of a case

Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report

Metastasis of Primary Colon Cancer to the Breast – Leave Well Alone

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