Metastasis of Primary Colon Cancer to the Breast – Leave Well Alone

Barthelmes, Ludger; Simpson, J. A.; Douglas-Jones, Anthony; Sweetland, Helen

doi:10.1159/000272303

Cited by 20 publications

(17 citation statements)

References 12 publications

(7 reference statements)

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“…Survival from time of diagnosis of metastasis to breast is less than 12 months [24]. Barthelmes et al advocated that surgical excision should be avoided in the view of short life expectancy and risk of seeding to the skin [25]. In our case we went for excision of breast lump despite of known short life expectancy of these patients, but due to urological problem of hydronephrosis in both kidneys patient developed urosepsis and died.…”

Section: Discussionmentioning

confidence: 80%

“…Laparoscopic colon surgery is known cause of skin metastasis [13]. In a study of 19 cases of breast metastasis from colon, 3 of the 19 patients presented synchronously, while the rest presented at median 15 months after diagnosis of colon cancer, lymph node involvement in 5 of 10 cases with median follow-up of 15 months, 5 died at the last follow-up [14]. The incidence of breast metastasis at the same time of detection of colon cancer is low, with only three cases reported so far [15].…”

Section: Discussionmentioning

confidence: 99%

“…Gastrointestinal carcinoids have also been reported to have metastatisize to breast [6] [7]. Metasta-sis to breast from colon cancer is extremely rare and only 20 cases have been reported in literature [8]. We present a case of colonic adenocarcinoma, which after undergoing abdominoperineal resection and radiotherapy and chemotherapy, metastasized to breast.…”

Section: Introductionmentioning

confidence: 95%

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Rectal Cancer Metastasizing to Breast: A Case Report and Review of Literature

Hejazi¹,

Alghamdi²,

Zaidi³

2016

CRCM

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Objectives: To report rare metastasis in breast from rectal cancer. Case Report: A 47-year-old married lady who presented with rectal bleeding for six weeks and diagnosed as a case of adenocarcinoma with no metastasis underwent neoadjuvent radiotherapy and chemotherapy and then abdominoperineal resection on follow-up found to have left breast mass and skin lesion in upper abdominal wall. Mammogram showed BIRADS-5. Tru cut biopsy showed mucinous/signet ring adenocarcinoma and she underwent lumpectomy and sentinel lymph node biopsy and excision of skin lesion. Histopathology of breast lump and skin lesion came as mucinous adeno-carcinoma of colonic origin, but all axillary lymph nodes were negative for malignancy. Conclusion: Metastatic breast lump is rare entity and every effort to be put to diagnose it using modern diagnostic tools.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Rectal Cancer Metastasizing to Breast: A Case Report and Review of Literature

Hejazi¹,

Alghamdi²,

Zaidi³

2016

CRCM

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“…Since their first description, in 1976 [4], only 20 cases have been reported so far [5]. The majority of patients have undergone surgical excision even though breast surgery, in these cases, was aimed only at diagnosis and/or palliation.…”

Section: Discussionmentioning

confidence: 99%

Breast metastasis of primary colon cancer with micrometastasis in the axillary sentinel node: A metastasis that metastasized?

Perin

Canzonieri

Memeo³

et al. 2011

Diagn Pathol

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A case of single breast metastasis from colon adenocarcinoma, with omolateral axillary micrometastasis, is reported with a brief review of the pertinent literature. The originality of the oncological concept of metastasis from metastasis, through lymphatics penetration, is discussed in the setting of a rare condition of breast metastasis from a colorectal carcinoma.The demonstration of axillary lymph node micrometastasis has been possible because fine needle aspiration cytology of the breast nodule was suspicious, but not conclusive for metastasis from colon cancer, so lumpectomy with sentinel node biopsy was planned.Although no disseminated nodal metastases were evident on computerized tomography scan and ultrasonography before breast surgery, the patient developed brain metastases and deteriorated rapidly; she died 16 months after presenting with the breast mass.In conclusion, solid cancers are able to further metastasize, via well-known pathways also recognized in primary cancers such as neoplastic cell invasion of peritumoral lymphatics.

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“…It is recommended that to avoid surgical operations in the case of presenting these symptoms (7). In a study, Barthelmes et al advocated to avoid unnecessary surgical interventions because of short survival expectation and risk of skin planting (8). Skin metastase is very rare as the breast metastase and indicators of poor prognosis.…”

Section: Dıscussıonmentioning

confidence: 99%

Colon Carcinoma Metastasizing to Skin and Breast - Rare Metastasis Sites: A Case Report

Aytekin¹,

Karataş²,

Hacıoğlu³

et al. 2015

Akd Med J

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Colorectal cancer (CRC) is the third most common cancer in the world and second most common cause of cancer mortality after lung cancer. Metastasis to the regional lymph nodes are found in 40-70% of cases at the time of resection, with metastasis to more distant sites occurring most frequently in the liver, peritoneal cavity, and lung, followed by the adrenals, ovaries, and bone. it is a rare case for a CRC to metastasis to skin and breast and that indicates advanced disease. In this case we reported a 64-year-old female CRC patient presenting with cervical and intra abdominal lymph nodes metastase a short time after adjuvant chemotherapy treatment and subsequent developing breast and diffuse skin metastase at initial of new cure chemotherapy. Because of skin and breast metastase related to colorectal cancers are so rare we try to inform this case to literature. Key Words: Colorectal cancer, Breast metastasis, Skin metastasis ÖzKolorektal kanser dünya çapında en sık görülen üçüncü ve akciğer kanserinden sonra en sık ölüme neden olan ikinci malignitedir. Rezeksiyon sırasında hastaların %40-70'inde rejyonel lenf nodu metastazı varken, uzak metastazlar en sık karaciğer, peritoneal kavite ve akciğere, daha nadir olarak da adrenaller, overler ve kemiklere olmaktadır. Bu olguda 64 yaşında kolon kanseri nedeniyle adjuvan kemoterapi alan kadın hastada kısa süre sonra gelişen servikal ve intraabdominal lenf nodu metastazı gelişmesini ve yeni başlanan kemoterapi rejiminden kısa süre sonra meme ve cilt metastazı gelişmesini rapor ettik. Kolorektal kanserlerde meme ve cilt metastazlarının çok nadir olması nedeniyle bu olguyu litaratüre bidirmek istedik. Colorectal cancer the third most common cancer in the world and second most common cause of cancer mortality after lung cancer. The risk for colorectal cancer increases with age, but 3% of colorectal cancers occur in patients younger than 40 years of age. Multiple factors like polyps, diet, inflammatory bowel disease, genetics and smoking drive the transformation of healthy colorectal mucosa to cancer. Genetic and environmental factors, such as maintaining a low body mass index and exercising regularly, correlate with lower incidence rates. Metastases to the regional lymph nodes are found in 40-70 % of cases at the time of resection, with metastases to more distant sites occurring most frequently in the liver, peritoneal cavity, and lung, followed by the adrenals, ovaries, and bone (1). It is a rare case for a CRC to metastasis to skin and breast and that indicates advanced disease. Breast metastasis of CRC is an uncommon case with a poor prognosis. The development of breast metastases is exceptionally rare, account for 0.43 % of all breast malignancies and is associated with poor clinical outcome (2). It is reported that skin

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Metastasis of Primary Colon Cancer to the Breast – Leave Well Alone

Cited by 20 publications

References 12 publications

Rectal Cancer Metastasizing to Breast: A Case Report and Review of Literature

Rectal Cancer Metastasizing to Breast: A Case Report and Review of Literature

Breast metastasis of primary colon cancer with micrometastasis in the axillary sentinel node: A metastasis that metastasized?

Colon Carcinoma Metastasizing to Skin and Breast - Rare Metastasis Sites: A Case Report

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