Breast hamartoma: a clinicopathologic analysis of 27 cases and a literature review

Abstract

OBJECTIVES:Breast hamartoma is an uncommon breast tumor that accounts for approximately 4.8% of all benign breast masses. The pathogenesis is still poorly understood and breast hamartoma is not a well-known disorder, so its diagnosis is underestimated by clinicians and pathologists. This study was designed to present our experience with breast hamartoma, along with a literature review.METHOD:We reviewed the demographic data, pathologic analyses and imaging and results of patients diagnosed with breast hamartoma between December 2003 and September 2013.RESULTS:In total, 27 cases of breast hamartoma operated in the Ankara University Medicine Faculty's Department of General Surgery were included in the study. All patients were female and the mean age was 41.8±10.8 years. The mean tumor size was 3.9±2.7 cm. Breast ultrasound was performed on all patients before surgery. The most common additional lesion was epithelial hyperplasia (22.2%). Furthermore, lobular carcinoma in situ was identified in one case and invasive ductal carcinoma was observed in another case. Immunohistochemical staining revealed myoid hamartoma in one case (3.7%).CONCLUSION:Breast hamartomas are rare benign lesions that may be underdiagnosed because of the categorization of hamartomas as fibroadenomas by pathologists. Pathologic examinations can show variability from one case to another. Thus, the true incidence may be higher than the literature indicates.

Breast hamartoma: ultrasound, elastosonographic, and mammographic features. Mini pictorial essay

“…Hamartoma of the breast was described for the first time in 1971 by Arrigoni et al Depending on the predominant type of breast tissue involved, the masses were referred to as ''lipofibroadenoma'', ''fibroadenolipoma'', or ''adenolipoma'' [2]. In 1973, Davies and Riddell introduced the term myoid hamartoma to refer to those rare hamartomas that contain substantial amounts of smooth muscle tissue [3].…”

Myoid hamartoma breast with pseudo angiomatous stromal hyperplasia: a case report and review of literature

“…According to the literature the average age of the patients with breast hamartoma ranged between 19-56 years. 4 The patient's age in our case was 17 years which is the lowest age reported so far in the literature. Clinically, myoid hamartomas present as firm, mobile, well-defined, non-tender breast lumps which may be mistaken as fibro adenoma.…”

Masq U Erading Mammary Hamartomas

“…In the present series 6 patients were above 35years of age. [1,5,8,9] 16 cases in the present study were suspected to be fibroadenomas and 2 cases were cystosarcoma phyllodes on clinical examination.…”

“…[Fig. 2, 3 [1,5,6,7] In the case series of breast hamartomas by Charpin et al and Sevim et al, the age ranged between 19-56 yrs. and 33.5-66.5 yrs respectively.…”

“…On microscopy, the presence of fibrotic and hyaline stroma which surrounds and extends between individual lobules leading to obliteration of the usual interlobular specialized loose stroma, is observed by many authors to be the most characteristic feature. [1,5,7] This is referred to as interlobular fibrosis. However this feature is also seen in other benign proliferative conditions like sclerosing adenosis.…”