Breast Fine-Needle Aspiration: A Comparison of ThinPrep and Conventional Smears

Bédard, Yvan C.; Pollett, Aaron

doi:10.1093/ajcp/111.4.523

Cited by 44 publications

(37 citation statements)

References 4 publications

(4 reference statements)

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“…An earlier study showed that the diagnostic accuracy of cytological material of body fluids and FNA specimens prepared by TP was the same as those of CS [10]. Another study compared large series of breast aspirates prepared by CS (21,193 cases) or TP (7,903 cases) and found comparable rates of sensitivity (CS: 84.4%, TP: 86.3%), specificity (CS: 98.6%, TP: 96.5%) and positive (CS: 96.5%, TP: 95.0%) and negative (CS: 91.1%, TP: 88.0%) predictive values for both types of cytological preparations [26]. Biscotti et al [14] matched CS and TP preparations obtained by aspirates from 75 surgically resected breast lesions (including 32 carcinomas) and observed 100% sensitivity for the detection of malignancy for both methods.…”

Section: Diagnostic Performancementioning

confidence: 99%

Liquid-Based Cytology in Fine-Needle Aspiration of Breast Lesions: A Review

Gerhard

Schmitt²

2014

Acta Cytologica

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Objective: Fine-needle aspiration (FNA) is a safe and cost-effective technique for the diagnosis of breast lesions, especially when correlated with clinical and imaging studies. However, the success of breast FNA is highly dependent on the adequate preparation of cytological conventional smears (CS). The liquid-based cytology (LBC) technique consists of an automated method for preparing thin-layer cytological samples from cell suspensions collected in alcohol-based preservative. LBC is designed to improve CS by avoiding limiting factors such as obscuring material, air-drying and smearing artifacts. Study Design: We performed a review of the published literature about LBC applied to breast FNA. Results: LBC preparations of breast aspirates demonstrated better cellular preservation, less cell overlapping and elimination of blood and excessive inflammation compared to CS. Conversely, alterations in architecture and cell morphology as well as loss of myoepithelial cells and stromal elements have been described in LBC specimens, requiring training before applying this technique for diagnosis. Studies have shown a similar accuracy between LBC and CS for the diagnosis of breast lesions. LBC also permits the use of residual material for ancillary tests, which is an important advantage compared to CS. Conclusions: LBC can be safely applied to breast FNA, showing a similar diagnostic accuracy to CS.

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Section: Diagnostic Performancementioning

confidence: 99%

Liquid-Based Cytology in Fine-Needle Aspiration of Breast Lesions: A Review

Gerhard

Schmitt²

2014

Acta Cytologica

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“…Thus the diagnostic accuracy of MLBC was similar to CS which was comparable with authors like Pawar PS et al 24 and Leung CS et al 18 MLBC and CS showed a sensitivity and specificity of 95.2% and 100% respectively whereas positive predictive value and negative predictive value of both methods were 100% and 96.9% respectively, which were comparable with other studies (Table 5). 16,18,21,24,25,26 …”

Section: Mlbc Vs Csmentioning

confidence: 99%

Manual Liquid Based Cytology in Breast Fine Needle Aspiration – Comparison with the Conventional Smear

Mahinderu¹,

Nandini²,

Kishore³

et al. 2016

IOSR

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“…ThinPrep (Cytyc, Boxborough, Mass., USA) is one of the most widely used cell preparation systems [1,2,3,4,5,6]. The superiority of ThinPrep slides to conventional preparations includes clear background, monolayer cell preparation and cell preservation [7,8].…”

Section: Introductionmentioning

confidence: 99%

An Aspiration Material Preparation System: Application of a New Liquid-Based Cytology Technique for Fine-Needle Aspiration of the Breast

Sakakibara

Kimachi²,

Hashimoto³

et al. 2010

Acta Cytologica

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Objective: To evaluate the usefulness of our original liquid-based cell preparation system AMAPS (aspiration material preparation system) and to compare it with the AutoSmear system in breast aspiration cytology. Study Design: A total of 487 specimens of fine-needle aspiration cytology of the breast were retrieved, of which 250 were processed with AMAPS and 237 with the AutoSmear method (before the introduction of AMAPS). A final histological diagnosis was obtained by an excisional biopsy or a surgical resection in 148 cases. Results: Cell recovery rates were significantly improved with AMAPS (96.8 and 99.1% in Papanicolaou and Diff-Quik, respectively) compared with the AutoSmear method (40.9 and 42.3%, respectively; p < 0.01). Within-run and day-to-day reproducibility of cell recovery was satisfactory, with coefficients of variations of 6.8 and 8.7%, respectively. Following the introduction of AMAPS in breast cytology, the unsatisfactory rate decreased significantly (from 16.0 to 8.8%; p < 0.01), while the diagnostic sensitivity for malignancy did not change (97.8 to 98.1%). Moreover, the diagnostic specificity for benign lesions increased from 75 to 93.8%, thus decreasing the excision rate of fibrocystic disease. Conclusion: AMAPS may serve as an alternative to the conventional technique or commercially available liquid-based cytology systems.

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Breast Fine-Needle Aspiration: A Comparison of ThinPrep and Conventional Smears

Cited by 44 publications

References 4 publications

Liquid-Based Cytology in Fine-Needle Aspiration of Breast Lesions: A Review

Liquid-Based Cytology in Fine-Needle Aspiration of Breast Lesions: A Review

Manual Liquid Based Cytology in Breast Fine Needle Aspiration – Comparison with the Conventional Smear

An Aspiration Material Preparation System: Application of a New Liquid-Based Cytology Technique for Fine-Needle Aspiration of the Breast

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