Breast-Feeding and Responses to Infant Vaccines: Constitutional and Environmental Factors

Dórea, José G.

doi:10.1055/s-0032-1316442

Cited by 15 publications

(10 citation statements)

References 109 publications

(139 reference statements)

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“…A study carried out in Sweden indicates that children with exclusive breastfeeding for 90 days or more who had the Hib and pneumococcal vaccine, concurrently, obtained better serological protection when compared to children who were breastfed for a few days 21 . In this way, its corroborates that these practices carried out concomitantly, exclusive breastfeeding for six months and the fulfillment of the immunization schedule, could give a greater protection to children in this age group 7 , 21 .…”

Section: Discussionsupporting

confidence: 68%

Cumprimento do esquema vacinal em crianças internadas por pneumonia e fatores associados

et al. 2018

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OBJECTIVE:To verify the adequacy and factors associated with compliance with the immunization schedule (BCG, DTP-Hib, MMR, PCV-10) in children hospitalized with pneumonia at a pediatric referral hospital in Northeast Brazil.METHODS:This is a cross-sectional, descriptive study with an analytical component, with a sample of 452 children hospitalized with pneumonia at the Instituto de Medicina Integral Prof. Fernando Figueira, between 2010 and 2013. The inclusion criterion was children aged from one month to less than five years of age with proof in the immunization record. The exclusion criterion was the presence of hospital-acquired pneumonia or concomitant disease. We have evaluated the adequacy of the immunization schedule for the BCG, tetravalent, MMR, and 10-valent pneumococcal conjugate (PCV-10) vaccines. We used the chi-square test and Fisher's exact test followed by multivariate Poisson regression, estimating the crude and adjusted prevalence ratios and respective 95% confidence intervals. The variables with p < 0.20 in the univariate analysis were included in the multivariate analysis.RESULTS:There was good adequacy in the immunization schedule, except for PCV-10, which presented a percentage lower than 85%. We have observed an association between adequate compliance with the immunization schedule and education level of the mother (89.9% complete high school), sex of the child (87.2% female), age of the child (94.2% younger than six months), and breastfeeding (84.3% breastfed).CONCLUSIONS:Given the high rate of education level of the mother and the high percentage of breastfeeding, we can understand that there is a better understanding of the health of the child by the mothers studied in this study, showing the effectiveness of public policies for infant feeding. However, children did not have good adequacy of the immunization schedule of PCV-10, one of the main vaccines against pneumonia, which can be one of the main factors in the causes of hospitalization, with no influence on the classification of the severity of the disease. In this way, we emphasize that the causes of pneumonia morbidity are not associated with a single factor.

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Section: Discussionsupporting

confidence: 68%

Cumprimento do esquema vacinal em crianças internadas por pneumonia e fatores associados

et al. 2018

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“…Although breastfeeding is essential to modulate immune defences, vaccines are crucial to prevent infectious diseases. However, maternal factors related to breastmilk constituents and feeding practices can affect the response to vaccines [38]. A study by Dórea indicated that maternal constitutional and environmental factors and feeding practices can affect the response to vaccines.…”

Section: Maternal Vaccination Strengthens Breastmilk Immunitymentioning

confidence: 99%

“…A study by Dórea indicated that maternal constitutional and environmental factors and feeding practices can affect the response to vaccines. Sucklings without receiving the full benefit of breastfeeding could have altered immune responses affecting vaccine outcome [38]. The study concluded that vaccination practices should encourage the practice of exclusive breastfeeding [38].…”

Section: Maternal Vaccination Strengthens Breastmilk Immunitymentioning

confidence: 99%

Breastfeeding as a Tool that Empowers Infant Immunity through Maternal Vaccination

Alasil¹

2015

J Vaccines Vaccin

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The dawn of maternal vaccination is an important milestone in breastmilk immunity. Breastmilk per se has immunopotential that protects the infant from important childhood diseases both in the immediate neonatal period and in the long term. Its immune nutritive attributes confer this exclusive early nourishment a cutting edge in defence that no other human nutrient can yet offer. Evidence that breastmilk is important in maturing the naiveté immune system and its potential to differentiate commensal and pathogenic microbes as well as its antimicrobial action are briefly reviewed. The vulnerability of the neonatal period to diseases and the increasing incidence of antibiotic resistance to pathogens must prompt us to continue to seek avenues through which primary disease preventive strategies can be emphasized and indeed improved. The advent of maternal vaccination has made it necessary that review and much research are both needed for elucidating the enrichment of the immune potential in breastmilk and how, because of it, some focused protective immunological responses may be triggered by further empowering the immunological potential of breastmilk constituents.. Primary disease prevention is achieved both by breastfeeding and by vaccination. We review here how the usefulness of breastfeeding and maternal vaccination may further empower breastmilk immunology.

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“…Although the finding that longer breastfeeding is associated with a poorer response to BCG vaccination seems paradoxical, a significant literature supports the idea that the relationship between breastfeeding and vaccine responses is complex. For instance, studies have reported enhanced, decreased, or no difference in the immune response to some vaccinations, comparing breastfed to non-breastfed infants ( Dórea 2012 ). For BCG vaccines specifically, one study observed that breastfeeding enhanced lymphocyte blastogenesis (stimulated by purified protein derivative of Mycobacterium tuberculosis ) ( Pabst et al 1989 ), and a second study, that examined Mantoux test results at 6 months, found no difference in tuberculin response size across different strata of breastfeeding duration ( Goh et al 1989 ).…”

Section: Discussionmentioning

confidence: 99%

A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination

Jusko

Roos

Lee

et al. 2016

Environ Health Perspect

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Background:Reasons for the highly variable and often poor protection conferred by the Mycobacterium bovis bacille Calmette–Guérin (BCG) vaccine are multifaceted and poorly understood.Objectives:We aimed to determine whether early-life exposure to PCBs (polychlorinated biphenyls) and DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene] reduces 6-month infant BCG vaccine response.Methods:Data came from families participating in a prospective birth cohort in eastern Slovakia. At birth, maternal and cord blood were collected for chemical analyses, and infants were immunized with BCG. Blood was collected from infants for chemical analyses and to determine 6-month BCG-specific immunoglobulin (Ig) G and IgA levels. Multivariable linear regression models were fit to examine chemical–BCG associations among approximately 500 mother–infant pairs, with adjustment for confounders.Results:The median 6-month infant concentration of the prevalent congener PCB-153 was 113 ng/g lipid [interquartile range (IQR): 37–248], and 388 ng/g lipid (IQR: 115–847) for DDE. Higher 6-month infant concentrations of PCB-153 and DDE were strongly associated with lower 6-month BCG-specific antibody levels. For instance, BCG-specific IgG levels were 37% lower for infants with PCB-153 concentrations at the 75th percentile compared to the 25th percentile (95% CI: –42, –32; p < 0.001). Results were similar in magnitude and precision for DDE. There was also evidence of PCB–DDE additivity, where exposure to both compounds reduced anti-BCG levels more than exposure to either compound alone.Conclusions:The associations observed in this study indicate that environmental exposures may be overlooked contributors to poorer responses to BCG vaccine. The overall association between these exposures and tuberculosis incidence is unknown.Citation:Jusko TA, De Roos AJ, Lee SY, Thevenet-Morrison K, Schwartz SM, Verner MA, Palkovicova Murinova L, Drobná B, Kočan A, Fabišiková A, Čonka K, Trnovec T, Hertz-Picciotto I, Lawrence BP. 2016. A birth cohort study of maternal and infant serum PCB-153 and DDE concentrations and responses to infant tuberculosis vaccination. Environ Health Perspect 124:813–821; http://dx.doi.org/10.1289/ehp.1510101

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Breast-Feeding and Responses to Infant Vaccines: Constitutional and Environmental Factors

Cited by 15 publications

References 109 publications

Cumprimento do esquema vacinal em crianças internadas por pneumonia e fatores associados

Cumprimento do esquema vacinal em crianças internadas por pneumonia e fatores associados

Breastfeeding as a Tool that Empowers Infant Immunity through Maternal Vaccination

A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination

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