Breast feeding and multiple sclerosis

Pisacane, Alfredo; Impagliazzo, Nicola; Russo, María Luisa; Valiani, R; Mandarini, A; Florio, Ciro; Vivo, Pasquale

doi:10.1136/bmj.308.6941.1411

Cited by 55 publications

(28 citation statements)

References 5 publications

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“…Greater understanding of fetal development and early maternal influences on the fetus and child is needed. A multitude of early risk factors could potentially be involved, for example, the length of breast feeding has been associated with susceptibility to MS [22] . Studies recording information on such developmental influences are required before the early origins of MS can be assessed to a greater extent.…”

Section: Discussionmentioning

confidence: 99%

No Effect of Birth Weight on the Risk of Multiple Sclerosis

et al. 2008

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Background: Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. A clear maternal effect has been shown in several population-based studies. This parent-of-origin effect could result from factors operating during gestation. It has been shown that a low birth weight increases the risk of several adult-onset diseases. In a population-based Canadian cohort, we investigated whether there is any difference in birth weight for MS index cases compared to spousal controls. Methods: Using the longitudinal Canadian database, we identified 6,188 MS index cases and 1,640 spousal controls with birth weight information. Additionally, data were available on 164 discordant MS twins. The birth weight was compared between index cases and controls as well as for twin pairs. Results: When stratifying by sex, no significant difference in birth weight was found (average female index case birth weight = 7.23 pounds, average female control birth weight = 7.19 pounds, p = 0.48; average male index case birth weight = 7.56 pounds, average male control birth weight = 7.55 pounds, p = 0.92). Furthermore, there was no difference in birth weight between affected and unaffected twins (average affected twin weight = 5.46 pounds, average unaffected twin weight = 5.44 pounds, p =0.85). Conclusions: The maternal effect in MS aetiology does not appear to act through a route that has an influence on birth weight. As birth weight is a relatively poor marker of fetal development, other factors involved in fetal and early development need to be explored to elucidate the mechanism of the increased MS risk conferred maternally.

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Section: Discussionmentioning

confidence: 99%

No Effect of Birth Weight on the Risk of Multiple Sclerosis

et al. 2008

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“…Two retrospective studies investigated the role of breastfeeding on the incidence of MS, but results of the studies were not conclusive (14,15).…”

Section: Diet As a Cause Of Msmentioning

confidence: 99%

Nutrition in multiple sclerosis

Habek

Hojsak

Brinar

2010

Clinical Neurology and Neurosurgery

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“…While 14 It is well established that pre-term and full-term infants fed on formula feeds have lower plasma and erythrocyte levels of DHA and AA than breastfed infants. 15,16 Several studies [17][18][19] have shown a correlation between infant feeding and the development of neuropsychiatric disorders. There is further, growing evidence that functional neurodevelopment is abnormal in infants and children who later develop schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Longer duration of breastfeeding associated with risk of developing schizophrenia

2007

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Background. Some studies have suggested that breastfeeding may be protective against the development of schizophrenia. Such a theory supports the neurodevelopmental hypothesis of schizophrenia. Objective. To determine whether there were differences in breastfeeding patterns between patients with schizophrenia and controls. Method. Fifty subjects with schizophrenia and 50 age- and gender-matched controls were included in the study. All subjects and their mothers were interviewed using a structured questionnaire to determine the extent of breastfeeding in infancy and age of onset of psychosis.Results. There was a significant difference in the duration of breastfeeding in patients versus controls (p < 0.05). Conclusion. Breastfeeding seems to be protective against the development of schizophrenia. This supports the neurodevelopmental hypothesis of this disorder and may be indicative of the role of essential fatty acids in normal brain development and the prevention of schizophrenia.

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Breast feeding and multiple sclerosis

Cited by 55 publications

References 5 publications

No Effect of Birth Weight on the Risk of Multiple Sclerosis

No Effect of Birth Weight on the Risk of Multiple Sclerosis

Nutrition in multiple sclerosis

Longer duration of breastfeeding associated with risk of developing schizophrenia

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