Breast-Conserving Treatment in the Elderly: Long-Term Results of Adjuvant Hypofractionated and Normofractionated Radiotherapy

Kirova, Youlia; Campana, F.; Savignoni, Alexia; Laki, Fatima; Muresan, M.; Dendale, R.; Bollet, Marc A.; Salmon, Rémy; Fourquet, A.

doi:10.1016/j.ijrobp.2008.11.005

Cited by 93 publications

(31 citation statements)

References 18 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this new development the total time of postoperative radiotherapy (RT) may be considerably reduced to one-half and perhaps to one-third. This objective implies a new fractionation policy, with far less fractions being administered and consequently an increase of radiotherapy dosage for each application [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons

Veronesi

Orecchia

Luini

et al. 2010

Breast Cancer Res Treat

194

109

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons

Veronesi

Orecchia

Luini

et al. 2010

Breast Cancer Res Treat

194

109

View full text Add to dashboard Cite

show abstract

“…Late effects, most commonly induration, were classified as grade 1 in 19 cases, grade 2 in 21 cases and grade 3 in 6 patients at a median of 41 months. In another French series, 50 patients were given 5 once-weekly fractions of 6.5 Gy to the whole breast as adjuvant therapy after breast conservation surgery, without a tumour bed boost dose [12]. Grade 1 or 2 induration was reported in 33% of the patients at a median follow up of 93 months (range 9-140), and no grade 3 or 4 effects were reported.…”

Section: Introductionmentioning

confidence: 99%

First results of the randomised UK FAST Trial of radiotherapy hypofractionation for treatment of early breast cancer (CRUKE/04/015)

Agrawal¹,

Alhasso²,

Barrett-Lee³

et al. 2011

Radiotherapy and Oncology

215

View full text Add to dashboard Cite

This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited.

show abstract

“…Study Institute Curie compared a group of patients treated by the above mentioned scheme with the group treated by standard fractionation. Although the results showed a similar local control, overall survival and diseasefree survival, given that there were great diff erences between the groups (the number of participants, age of the participants ...) and that they haven't thoroughly studied the toxicity, are subject to criticism (31). Currently there is an ongoing international randomized Phase II study SKA-GEN that examines the role of hypofractionated Protocol in the radiation of the lymphatic drainage in cases of early breast cancer.…”

Section: Radiation Protocolsmentioning

confidence: 78%

Radiation Therapy for Breast Cancer

2009

N Engl J Med

View full text Add to dashboard Cite

SummaryRadiation therapy represents an important aspect of breast cancer treatment. Application of irradiation reduces the incidence of local disease recurrence and improves overall survival of breast cancer patients. Studies have shown that adjuvant irradiation after breast-conserving surgery has the same result as a mastectomy, so adjuvant radiotherapy enables sparing surgery in breast cancer patients. We will review the mechanisms, indications and methods of the whole breast irradiation, as a standard approach to the treatment. The main directions and controversies of today's research will be shown, primarily the introduction of hypofractionation, i.e. distribution of high daily doses of irradiation in a shorter overall period of treatment, as well as the application of partial breast irradiation, i.e. irradiation of a part of the breast instead of postoperative irradiation of the whole breast. Further molecular analysis of tumor biology will lead to the new prognostic and predictive parameters, and thus to the further personalization in the fi eld of breast cancer radiotherapy. KEY WORDS: breast cancer, radiotherapy, breast-conserving surgery ZRAČENJE U LIJEČENJU RAKA DOJKE SažetakRadioterapija je koristna u liječenju raka dojke. Smanjuje pojavu lokalnog recidiva i produljuje preživljenje. Studije su pokazale da adjuvantno zračenje nakon poštednog kirurškog zahvata ima iste rezultate kao mastektomija i omogućuje primjenu poštedne kirurgije. Kao standardni pristup liječenja prikazani su mehanizmi, indikacije i metode zračenja cijele dojke. Razmatrani su smjerovi i kontroverze istraživanja, hipofrakcioniranje, (primjene većih dnevnih doza u kraćem ukupnom vremenskom razdoblju) i djelomično zračenje dojke, umjesto standardnog poslijeoperacijskog zračenja cijele dojke. Dodatne molekularne analize biologije tumora dovest će do novih prognostičkih i prediktivnih čimbenika, a time i do dodatne personalizacije u području radioterapije raka dojke.

show abstract

Breast-Conserving Treatment in the Elderly: Long-Term Results of Adjuvant Hypofractionated and Normofractionated Radiotherapy

Cited by 93 publications

References 18 publications

Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons

Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons

First results of the randomised UK FAST Trial of radiotherapy hypofractionation for treatment of early breast cancer (CRUKE/04/015)

Radiation Therapy for Breast Cancer

Contact Info

Product

Resources

About