Breast conserving treatment (BCT) for stage I–II breast cancer in elderly women: Analysis of 927 cases

Cutuli, B.; Lafontan, B. De; Vitali, Ettore; Costa, Loredana; Aristei, Cynthia; Marchal, C.; Quétin, Philippe; Fay, Renaud

doi:10.1016/j.critrevonc.2008.09.011

Cited by 25 publications

(16 citation statements)

References 103 publications

(124 reference statements)

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“…Certains auteurs é voquent le rô le facilitateur du traitement hormonal substitutif dans les anté cé dents. Une composante intracanalaire extensive est rarement retrouvé e. Les tumeurs infiltrantes de bas grade, diploïdes [34,44] et à index mitotique faible [39,127] sont plus fré quentes.…”

Section: Prise En Charge Chirurgicaleunclassified

“…Les ré sultats, en termes de contrô le à cinq ans, sont trè s significativement en faveur de celle-ci. Dans trois é tudes ré centes [39,116,159], ayant utilisé la radiothé rapie aprè s chirurgie conservatrice, les ré sultats en termes de contrô le local sont excellents, avec respectivement 3, 2,3 et 4,4 % de rechutes à 65, 65 et 88 mois respectivement, et cela tant avec un sché ma classique qu'avec un sché ma hypofractionné .…”

Section: Hormonothé Rapie Né Oadjuvanteunclassified

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Le cancer du sein chez la femme âgée (hors situation métastatique)

2009

Oncologie

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Section: Prise En Charge Chirurgicaleunclassified

Section: Hormonothé Rapie Né Oadjuvanteunclassified

Le cancer du sein chez la femme âgée (hors situation métastatique)

2009

Oncologie

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“…The 5-and 7-year cause-specific survival, locoregional relapse-free survival and metastases-free survival were similar to those of patients treated with conventional fractionation (with or without a boost to the tumor bed). Cutuli et al (27) reported on women older than 70 treated with BCS followed by WBRT, including 133 patients submitted to HF with 32.5 Gy in 5 weekly fractions. The authors reported excellent locoregional control, with no difference compared to patients treated with conventional WBRT.…”

Section: G2 G3 G4mentioning

confidence: 99%

Hypofractionated Whole-Breast Radiotherapy and Concomitant Boost after Breast Conservation in Elderly Patients

Cante

Franco

Sciacero

et al. 2015

Tumori

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Aims To report the 5- and 10-year results of accelerated hypofractionated whole-breast radiotherapy (WBRT) with concomitant boost to the tumor bed in 83 consecutive patients with early breast cancer aged >70 years. Methods All patients were treated with breast conservation and hypofractionated WBRT. The prescription dose to the whole breast was 45 Gy (2.25 Gy/20 fractions) with an additional daily concomitant boost of 0.25 Gy to the surgical cavity (2.5 Gy/20 fractions up to 50 Gy). The maximum detected toxicity was scored according to the Common Terminology Criteria for Adverse Events, version 3.0. We considered as skin toxicity: erythema, edema, desquamation, ulceration, hemorrhage, necrosis, telangiectasia, fibrosis-induration, hyperpigmentation, retraction and atrophy. Cosmetic results were assessed as set by the Harvard criteria. Results With a median follow-up of 60 months (range 36-88), no local recurrence was observed. The maximum detected acute skin toxicity was G0 in 57% of patients, G1 in 40% and G2 in 3%. Late skin and subcutaneous toxicity was generally mild with no ≥G3 events. The cosmetic results were excellent in 69% of patients, good in 22%, fair in 5%, and poor in 4%. Conclusions The present results support the use of hypofractionation employing a concomitant boost to the lumpectomy cavity in women aged >70 years. This is a convenient treatment option for both this type of population and health-care providers.

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“…Au total, si on souhaitait retenir la notion de tumeur moins agressive chez le sujet âgé, cela ne pourrait s'appliquer qu'en comparaison du sous-groupe des « plus de 70 ans » avec celui des « moins de 40 ans », et non par rapport à la tranche d'âge 40-69 ans [5]. en oeuvre des actions préventives allant de la correction des facteurs de fragilité observés à l'aménage-ment de la stratégie thérapeutique, en passant par l'optimisation des soins de support.…”

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The place of targeted therapies in the treatment of breast cancer in elderly women

Spano

Théry

2011

Oncologie

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The increased incidence of breast cancer in elderly women leads us to consider the use of targeted therapies specifically in this population. Indeed, these treatments have contributed to a significant improvement in progression free survival and overall survival of patients with breast cancer. In the absence of studies confined to the elderly population, oncogeriatricians have a duty not only to collect objective data on efficacy and safety of targeted therapy from primary studies, but also to employ the oncogeriatric assessment process to look for the criteria of frailty specific to the elderly patient. As previously for chemotherapy, onco-geriatricians must deal with the lack of appropriate data and be content with sub-group information, from which the reliability of the evidence is uncertain. In this review, we examine data available in the literature on the use of targeted therapies in the management of breast cancer in elderly women, so as to guide the clinician in his choice of therapy and his management of toxicity in this growing population. To cite this journal: Oncologie 13 (2011).

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Breast conserving treatment (BCT) for stage I–II breast cancer in elderly women: Analysis of 927 cases

Cited by 25 publications

References 103 publications

Le cancer du sein chez la femme âgée (hors situation métastatique)

Le cancer du sein chez la femme âgée (hors situation métastatique)

Hypofractionated Whole-Breast Radiotherapy and Concomitant Boost after Breast Conservation in Elderly Patients

The place of targeted therapies in the treatment of breast cancer in elderly women

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